Richard Yanagihara, M.D., M.P.H.
Principal Investigator
Professor
Department of Pediatrics
John A. Burns School of Medicine
Hantaviridae, viral zoonoses, Eulipotyphla, Chiroptera
Office: BSB 320L
Phone: 808-692-1610
Email: ryanagih@hawaii.edu
| 1968 | B.A. | University of Hawaiʻi at Mānoa, Honolulu, Hawaiʻi |
|---|---|---|
| 1972 | M.D. | University of Cincinnati, College of Medicine, Cincinnati, Ohio |
| 1985 | M.P.H. | Johns Hopkins University, School of Hygiene and Public Health, Baltimore, Maryland |
| 1971 | Student Intern, Pasgeboren, Sophia Kinderziekenhuis, Rotterdam, the Netherlands (Henryk K.A. Visser, M.D.) |
|---|---|
| Student Intern, Sheffield Children’s Hospital, Western Bank, Sheffield, England (Ronald S. Illingworth, M.D.) | |
| Student Intern, Division of Infectious Diseases, Department of Medicine, Yale University, School of Medicine, New Haven, Connecticut (Robert H. Gifford, Jr., M.D.) | |
| 1972-1973 | Intern, Pediatrics (PL-1), Department of Pediatrics, University of Colorado Medical Center, Denver, Colorado (C. Henry Kempe, M.D.) |
| 1973-1974 | Resident, Pediatrics (PL-2), Department of Pediatrics, University of Colorado Medical Center, Denver, Colorado (Frederick C. Battaglia, M.D.) |
| 1974-1976 | Research Associate, Laboratory of Central Nervous System Studies, National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, Bethesda, Maryland (D. Carleton Gajdusek, M.D.) |
| 1976-1977 | Resident, Pediatrics (PL-3), Department of Pediatrics, University of California at San Francisco, San Francisco, California (Melvin M. Grumbach, M.D.) |
| 1977-1979 | Fellow, Division of Infectious Diseases, Department of Pediatrics, University of Colorado Health Sciences Center, Denver, Colorado (Kenneth McIntosh, M.D.) |
| 1979-1982 | Research Physician, NINCDS Research Center, Tamuning, Guam, and Laboratory of Central Nervous System Studies, National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, Bethesda, Maryland |
| 1982-1984 | Special Expert, Laboratory of Central Nervous System Studies, National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, Bethesda, Maryland |
| 1985-1988 | Medical Officer (tenured) and Project Officer, Laboratory of Central Nervous System Studies, National Institute of Neurological Disorders and Stroke, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, Maryland |
| 1988-1990 | Senior Investigator and Project Officer, Laboratory of Central Nervous System Studies, National Institute of Neurological Disorders and Stroke, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, Maryland |
| 1990-1995 | Section Chief (Research) and Project Officer, Laboratory of Central Nervous System Studies, National Institute of Neurological Disorders and Stroke, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, Maryland |
| 1995-2002 | Director, Retrovirology Research Laboratory, Research Centers in Minority Institutions Program, Pacific Biomedical Research Center, University of Hawaiʻi at Mānoa, Honolulu, Hawaiʻi |
| 1996-2001 | Leader, Human Retroviruses and Other Emerging Pathogens Activity, Research Centers in Minority Institutions Program, Pacific Biomedical Research Center, University of Hawaiʻi at Mānoa, Honolulu, Hawaiʻi |
| 1999-2000 | Associate Program Director, Research Centers in Minority Institutions Program, Pacific Biomedical Research Center, University of Hawaiʻi at Mānoa, Honolulu, Hawaiʻi |
| 2000-2011 | Director, Research Centers in Minority Institutions Program, John A. Burns School of Medicine, University of Hawaiʻi at Mānoa, Honolulu, Hawaiʻi |
| 2002-present | Professor (tenured), Department of Pediatrics, John A. Burns School of Medicine, University of Hawaiʻi at Mānoa, Honolulu, Hawaiʻi |
Research Keywords: Hantaviridae, viral zoonoses, Eulipotyphla, Chiroptera
Formerly a tenured intramural NIH investigator, Dr. Richard Yanagihara joined the Research Centers in Minority Institutions (RCMI) program at the University of Hawaiʻi at Mānoa through an interagency personnel agreement in 1995 to assist in building capacity for a laboratory-based retrovirology research program. He has served as the RCMI Program Director since 2000 and as the principal investigator of the Pacific Center for Emerging Infectious Diseases Research since 2003. As such, he has played a critical role in coordinating the development of much-needed infrastructure for infectious diseases research, which has involved direct mentoring of junior and mid-career faculty, as well as developing programs that award modest grant support for pilot projects, as well as bridging funds to faculty who are transitioning off of career development or departmental institutional support. Prior to joining the University of Hawaiʻi at Mānoa, Dr. Yanagihara was the on-site NINDS Project Officer of a ABSL-3/BSL-3 primate facility within the Laboratory of Central Nervous System Studies in Frederick, Maryland, where he supervised postdoctoral fellows and visiting scientists. His scientific explorations have taken the form of problem-based, disease-oriented, long-term, high-risk, multidisciplinary, opportunistic investigations of medically urgent phenomena of worldwide importance, conducted largely in the context of exploiting naturally occurring paradigms of high-incidence “place diseases” among human populations isolated by virtue of their genetics, culture and/or geography.
Cori Watanabe, M.B.A .
Program Coordinator
Department of Pediatrics
John A. Burns School of Medicine
Office: BSB 320
Phone: 808 692-1654
Email: corit@hawaii.edu
| 1997 | B.A. | University of Hawaiʻi at Mānoa, Honolulu, Hawaiʻi |
| 2005 | M.B.A. | University of Hawaiʻi at Mānoa, Honolulu, Hawaiʻi |
| 2003 - 2005 | Administrative and Fiscal Support, University of Hawaiʻi at Mānoa, Honolulu, Hawaiʻi |
| 2005 - present | Program Coordinator, University of Hawaiʻi at Mānoa, Honolulu, Hawaiʻi |
| April 2006 | National Council of University Research Administrators (NCURA) Regional Meeting - Lihue, Hawaiʻi |
| June 2009 | National Institutes of Health (NIH) Regional Seminar on Program Funding and Grants Administration - Las Vegas, Nevada |
| May 2011 | NCURA Departmental Research Administration Workshop - Minneapolis, Minnesota |
Apichai Tuanyok, Ph.D.Assistant Professor, Department of Infectious Diseases and Pathology, College of Veterinary Medicine, University of Florida, Gainesville, Florida
Burkholderia pseudomallei
Office: BSB 320F
Email: tuanyok@hawaii.edu
Burkholderia pseudomallei is the cause of melioidosis, a severe tropical disease that remains a public health problem in Southeast Asia and northern Australia. Because there is no vaccine for melioidosis, successful patient management is solely based on early diagnosis and subsequent treatment with antibiotics. B. pseudomallei exhibits very high recombination frequency in both its core and accessory genomes creating great strain-to-strain diversity. Gene differences that account for the virulence between B. pseudomallei and its close non-pathogenic relatives (e.g., B. thailandensis) are now being better understood, but the genetic and molecular basis for differential virulence, drug resistance, and physiology among B. pseudomallei strains remains unknown.
Hypothesis: Primary resistance to parental drugs e.g., ceftazidime and amoxicillin - clavulanic acid is relatively rare, while the resistance mostly occurs clinically. Mutations of the pathogen are not random, most of which are gene or site-specific that play important roles in resistance mechanisms.
Rationale: Identifying antibiotic resistance mechanisms in B. pseudomallei will provide proven and clinically relevant signatures for monitoring the development of antibiotic resistance in this deadly pathogen.
Experimental Plan: A large strain collection of drug resistant B. pseudomallei from around the world will be developed. Next generation sequencing e.g., Illumina and PacBio will be used to identify genetic markers such as SNPs of the mutations. The genetic markers (e.g., SNPs of Class A Beta-lactamase gene) will be characterized using allelic replacement. The mutants will be tested for pharmacokinetics against a series of antibiotics.
Hypothesis: We believe that novel approaches to vaccine development that target non-polysaccharide antigens are needed for melioidosis. Proteins are generally more antigenic than polysaccharides and induce antibody subclasses with high complement-fixing capacity. Extracellular and cell surface proteins can be considered as viable vaccine antigens.
Rationale: Identification of the secreted surface antigens and understanding of fundamental protective immunity are important for vaccine development against B. pseudomallei.
Experimental Plan: Proteomic analyses such as 2-dimentional electrophoresis (2-DGE), immunoblotting, and mass spectrometry will be used to identify surface and/or secreted antigens of B. pseudomallei. Heterologous expression and liquid chromatography will be used to purify the antigens. These antigens will be tested for protection against melioidosis in mouse models. Luminex and flow cytometry-based assays will be used to study protective immunity of these antigens.
Variable virulence factors in Burkholderia pseudomallei (melioidosis) associated with human disease.
PLoS One 2014Structural characterization of polysaccharides expressed by Burkholderia oklahomensis E0147.
Carbohydrate Research 2014Systematic review and consensus guidelines for environmental sampling of Burkholderia pseudomallei.
PLoS Neglected Tropical Diseases 2013Within-host evolution of Burkholderia pseudomallei over a twelve-year chronic carriage infection.
MBio 2013Complete genome sequence of the encephalomyelitic Burkholderia pseudomallei strain MSHR305.
Genome Announcements 2013
Brenda Hernandez, Ph.D.
Associate Professor (Researcher)
Cancer Center
University of Hawaiʻi at Mānoa Honolulu, Hawaiʻi
Cancer epidemiology, human papillomavirus, pathology
Email: brenda@crch.hawaii.edu
| 1987 | B.A. | (Biological Anthropology) Harvard University, Boston, MA |
| 1990 | M.P.H. | (Epidemiology) Yale University School of Medicine, New Haven, CT |
| 1999 | Ph.D. | (Epidemiology) University of Hawaiʻi at Mānoa, Honolulu, HI |
Research Keywords: Cancer epidemiology, human papillomavirus, pathology
My major research interest is the role of infection in the etiology of cancer. Human papillomavirus (HPV) is a major research focus. I have been involved in epidemiologic studies of HPV in both men and women and run an HPV testing laboratory. I am currently the PI of a CDC-funded study of HPV detection in men, Co-Investigator of an NCI-funded cohort study of HPV in females, and was previously the Project Leader of an NIH-funded investigation of the natural history of HPV in men. I am the Co-Principal Investigator of the Hawaiʻi Tumor Registry (HTR), which is part of the Surveillance Epidemiology and End Results Program of the National Cancer Institute. The HTR monitors trends in cancer incidence and mortality in the state and maintains a repository of cancer tissue specimens for research. I developed the Cancer Center’s Pathology Core laboratory, which provides histology and pathology services to support basic, epidemiologic, translational, and clinical research studies utilizing human tissue.
Reduced clearance of penile human papillomavirus infection in uncircumcised men.
Journal of Infectious Diseases 2010Acceptability of prophylactic human papillomavirus vaccination among adult men.
Human Vaccine 2010Mammographic density and matrix metalloproteinases in breast tissue.
Cancer Microenvironment 2009
Guylaine Poisson, Ph.D.
Advisor, Bioinformatics Core
Associate Professor
Department of Information and Computer Sciences
College of Natural Sciences
Office: POST 310
Phone: 808-956-3496
Email: guylaine@hawaii.edu
Prediction of mature microRNA and Piwi-interacting RNA without a genome reference or precursors.
International Journal of Molecular Science 2015The characterization of RNA viruses in tropical seawater using targeted PCR and metagenomics.
MBio 2014Multiclass relevance units machine: benchmark evaluation and application to small ncRNA discovery.
BMC Genomics 2013Probabilistic prediction of protein phosphorylation sites using kernel machines.
Proceedings of the 2012 ACM Symposium on Applied Computing BIO track 2012Efficient clustering of populations using a minimal SNP panel.
Proceedings of the 2011 ACM Symposium on Applied Computing 2011The evolution of the tape measure protein: units, duplications and losses.
BMC Bioinformatics 2011Mosaic graphs and comparative genomics in phage communities.
Journal of Computational Biology 2010Virus DNA-fragment classification using taxonomic hidden Markov model profile.
Proceedings of the 2010 ACM Symposium on Applied Computing 2010Divide and conquer: enriching environmental sequencing data.
PLoS One 2007Transcriptome comparison of winter and spring wheat responding to low temperature.
Genome 2006Pseudoknots in prion protein mRNAs confirmed by comparative sequence analysis and pattern searching.
Nucleic Acids Research 2001
Hongwei Li, Ph.D.
Assistant Professor
Department of Microbiology
College of Natural Sciences
Phone: 808-956-5518
Office: Snyder Hall 308E
Email: hli@hawaii.edu
| 1989 | B.Sc. | (Biology) Harbin Normal University, Harbin, China |
| 1992 | M.Sc. | (Microbial Genetics) Harbin Normal University, Harbin, China |
| 2001 | Ph.D. | (Molecular Virology) National University of Singapore, Singapore |
Molecular Virology
| 2002-present | American Society for Virology |
| 2006-present | American Society for Microbiology |
Research Keywords: Dengue virus, pathogenesis, RNAi
Dengue is the most prevalent mosquito-borne viral disease in humans. The overall objective of our research is to understand the molecular mechanisms of dengue virus-host interactions in both mosquito and human cells. We mainly focus on following research directions:
The life-threatening forms of dengue diseases, dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS), are manifested by increased vascular permeability and plasma leakage. Monocytes and macrophages are considered as the primary target cells of DENV infection, and vascular endothelial cells are the cells for final symptomatic manifestation. One of the major hypotheses for dengue viral pathogenesis is that massive infection of monocytes/macrophages results in a drastic increase in production of cytokines, which act on endothelial cells and cause alteration of endothelial permeability. The objective of our research is to investigate the role of miRNAs, the most abundant small regulatory RNAs in RNAi, in the pathogenesis of dengue infection.
Human apolipoprotein A-I is associated with dengue virus and enhances virus infection through SR-BI.
PLoS One 2013RNA interference directs innate immunity against viruses in adult Drosophila.
Science 2006Animal virus replication and RNAi-mediated antiviral silencing in Caenorhabditis elegans.
Nature 2005
Hyeyun Kang, Ph.D.
Senior Researcher
Division of Respiratory Viruses
Korea National Institute of Health
Korea 363-951
Phone: +82-43-719-8119
Email: hyeyun.kang@gmail.com
| 2004 | B.S. | Department of Microbiology, Hannam University, Daejeon, Korea |
| 2009 | M.S. | Department of Microbiology, Korea University, Seoul, Korea |
| 2009 | Ph.D. | Department of Microbiology, Korea University, Seoul, Korea |
Dissertation title: Genetic Diversity and Molecular Phylogeny of Newly Identified Soricid- and Talpid-Borne Hantaviruses
March 2011 - present
Senior Researcher, Division of Enteric Bacterial Infections, Korea National Institute of Health, Korea 363-951
September 2009 - January 2011
Junior Researcher, Pacific Center for Emerging Infectious Diseases Research,
John A. Burns School of Medicine, University of Hawaiʻi at Mānoa, Honolulu, Hawaiʻi 96813
January 2008 - August 2009
Research Technician, Pacific Center for Emerging Infectious Diseases Research,
John A. Burns School of Medicine, University of Hawaiʻi at Mānoa, Honolulu, Hawaiʻi 96813
Research Keywords: Hantavirus, evolution, phylogeography, Soricomorpha
Genetic diversity of Artybash virus in the Laxmann’s shrew (Sorex caecutiens).
Vector Borne and Zoonotic Diseases 2016Reconstructing the evolutionary origins and phylogeography of hantaviruses.
Trends in Microbiology 2014Co-circulation of soricid- and talpid-borne hantaviruses in Poland.
Infection, Genetics and Evolution 2014Expanded host diversity and geographic distribution of hantaviruses in sub-Saharan Africa.
Journal of Virology 2014Novel hantavirus in the flat-skulled shrew (Sorex roboratus).
Vector Borne and Zoonotic Diseases 2010Seewis virus: phylogeography of a shrew-borne hantavirus in Siberia, Russia.
Vector Borne and Zoonotic Diseases 2010Molecular phylogeny of a newfound hantavirus in the Japanese shrew mole (Urotrichus talpoides).
Proceedings of the National Academy of Sciences USA 2008
Jeffrey F. Miller, Ph.D.
Professor and M. Philip Davis Chair
Department of Microbiology, Immunology and Molecular Genetics
David Geffen School of Medicine
University of California at Los Angeles
Los Angeles, California
Phone: (310) 206-7926
Email: jfmiller@ucla.edu
Bordetella pertussis pathogenesis: current and future challenges.
Nature Reviews Microbiology 2014Propionibacterium acnes strain populations in the human skin microbiome associated with acne.
Journal of Investigative Dermatology 2013Phenotypic and genomic analysis of hypervirulent human-associated Bordetella bronchiseptica.
BMC Microbiology 2012Dissection of the Burkholderia intracellular life cycle using a photothermal nanoblade.
Proceedings of the National Academy of Sciences USA 2011Target site recognition by a diversity-generating retroelement.
PLoS Genetics 2011Three-dimensional structure of tropism-switching Bordetella bacteriophage.
Proceedings of the National Academy of Sciences USA 2010Pertactin is required for Bordetella species to resist neutrophil-mediated clearance.
Infection and Immunity 2010
Jin-Won Song, M.D., Ph.D.
Professor
Department of Microbiology
Director
Institute for Viral Diseases
College of Medicine
Korea University Seoul, Korea
Phone: +82-2-920-6408
Email: jwsong@korea.ac.kr
| 1987 | M.D. | Korea University, College of Medicine, Seoul, Korea |
| 1989 | M.S. | Department of Microbiology, Korea University Graduate School, Seoul, Korea |
| 1994 | Ph.D. | Department of Microbiology, Korea University Graduate School, Seoul, Korea |
| 1987-1990 | Teaching Assistant, Department of Microbiology, College of Medicine, Korea University |
| 1987-1990 | Researcher, WHO Collaborating Center for Virus Reference and Research (Hemorrhagic Fever with Renal Syndrome), The Institute for Viral Disease, Korea University, Seoul, Korea |
| 1990-1993 | Medical Officer (Captain), Division of Arboviruses, Department of Virology, National Institute of Health, Seoul, Korea |
| 1993-1997 | Visiting Fellow, Laboratory of Central Nervous System Studies, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, U.S.A. |
| 1996-1998 | Research Assistant Professor, Department of Microbiology, College of Medicine, Korea University, Seoul, Korea |
| 1998-2000 | Assistant Professor, Department of Microbiology, College of Medicine, Korea University, Seoul, Korea |
| 2000-2004 | Associate Professor, Department of Microbiology, College of Medicine, Korea University, Seoul, Korea |
| 2005-present | Professor, Department of Microbiology, College of Medicine, Korea University, Seoul, Korea |
| 2005-2006 | Visiting Scholar, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu HI, U.S.A. |
| 2008-2010 | Vice Dean for General affairs, College of Medicine, Korea University, Seoul, Korea |
| 2007-present | Director, Institute for Viral Diseases, Korea University, Seoul, Korea |
| 2008-present | Director on the Board, the Korea Support Committee for International Vaccine Institute, Seoul, Korea |
2011 Hantaan Prize, The Hantaan Life Science Foundation, Seoul, Korea
2011 Award, Korea National Academy of Sciences, Seoul, Korea
Research Keywords: Viral hemorrhagic fevers, hantavirus, rodent-borne diseases, respiratory viruses, virus evolution
Molecular phylogeny of hantaviruses harbored by insectivorous bats in Cote d’Ivoire and Vietnam.
Viruses 2014Whole-genome sequence of Muju virus, an arvicolid rodent-borne hantavirus.
Genome Announcements 2014Hantaviruses induce cell type- and viral species-specific host microRNA expression signatures.
Virology 2013Seewis virus, a genetically distinct hantavirus in the Eurasian common shrew (Sorex araneus).
Virology Journal 2007Muju virus, a novel hantavirus harboured by the arvicolid rodent Myodes regulus in Korea.
Journal of General Virology 2007
Kathryn V. Holmes, Ph.D.
Professor
Department of Microbiology
University of Colorado Health Science Center Denver, Colorado
Phone: (303) 724-4231
Email: kathryn.holmes@uchsc.edu
Innate immune response of human alveolar type II cells infected with SARS-coronavirus.
American Journal of Respiratory Cell and Molecular Biology 2013Infection of human alveolar macrophages by human coronavirus strain 229E.
Journal of General Virology 2012Crystal structure of bovine coronavirus spike protein lectin domain.
Journal of Biological Chemistry 2012Crystal structure of mouse coronavirus receptor-binding domain complexed with its murine receptor.
Proceedings of the National Academy of Sciences USA 2011Host-pathogen interactions during coronavirus infection of primary alveolar epithelial cells.
Journal of Leukocyte Biology 2009Expression and characterization of recombinant S2 subunit of SARS-coronavirus S fusion protein.
Advances in Experimental Medicine and Biology 2009
Kyungim Baek, Ph.D.
Advisor, Bioinformatics Core
Assistant Professor
Department of Information and Computer Sciences
College of Natural Sciences
Phone: (808) 956-8560
Office: POST 314F
Email: kyungim@hawaii.edu
Research Keywords: metagenomics, machine learning, visual perception, computer vision
Prediction of mature microRNA and Piwi-interacting RNA without a genome reference or precursors.
International Journal of Molecular Science 2015Multiclass relevance units machine: benchmark evaluation and application to small ncRNA discovery.
BMC Genomics 2013Probabilistic prediction of protein phosphorylation sites using kernel machines.
Proceedings of the 2012 ACM Symposium on Applied Computing BIO track 2012Efficient clustering of populations using a minimal SNP panel.
Proceedings of the 2011 ACM Symposium on Applied Computing 2011Virus DNA-fragment classification using taxonomic hidden Markov model profile.
Proceedings of the 2010 ACM Symposium on Applied Computing 2010Inferring direction of figure using a recurrent integrate-and-fire neural circuit.
Conference Proceedings of IEEE Engineering in Medicine and Biology Society 2004
Marc A. Le Pape, Ph.D.
Advisor, Bioinformatics Core Adjunct Specialist, Department of Tropical Medicine, Medical Microbiology and Pharmacology John A. Burns School of Medicine
Phone: (808) 692-1629
Office: BSB-320
Email: lepape@hawaii.edu
Marc A. Le Pape holds a PhD from the University of Hawaiʻi Interdisciplinary Program in Communication and Information Sciences, the institution original PhD program in Computer Sciences.
Current research investigates how cognitive design principles can be used to develop predictive models of human-computer interaction applicable to the design of mission-critical and safety-critical mobile systems that support optimal performance in the execution of perceptual-motor tasks without unnecessarily increasing cognitive load and the probability of critical errors. A member of the Association for Computing Machinery (ACM), Marc has taught computer programming, research methods, and statistics at the University of Hawaiʻi since 2000. His latest publication, An Experimental Study of Field Dependency in Altered Gz Environments, earned a Best Paper Honorable Mention at ACM CHI.
An evaluation of statistical methods for DNA methylation microarray data analysis.
BMC Bioinformatics 2015
Nuankanya Sathirapongsasuti, M.D., Ph.D.
Lecturer Translational Medicine Program Faculty of Medicine Ramathibodi Hospital Mahidol University 270 Rama VI Rd., Ratchathewi Bangkok 10400 Thailand
Phone: (66) 2-201-2613
Email: nuankanya.sat@mahidol.ac.th
| 2005 | M.D. | Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand |
| 2010 | Ph.D. | Department of Medical Genome Sciences, Graduate School of Frontier Sciences, University of Tokyo, Chiba, Japan |
Ok Sarah Shin, Ph.D.
Assistant Professor Department of Biomedical Sciences College of Medicine Korea University Seoul 136-705, Republic of Korea
Phone: 02 2626 3280
Email: sarahshin79@gmail.com
| 2002 | B.A. | Department of Biology, Clark University, Worcester, MA |
| 2003 | M.A. | Department of Biology, Clark University, Worcester, MA |
| 2009 | Ph.D. | Department of Immunology, Tufts University, Boston, MA |
Dissertation title: The Role of Innate Immunity in the Pathogenesis of Lyme Disease
2013-Present
Assistant Professor, Korea University, College of Medicine, Seoul, Korea
2011-2013
Assistant Research Professor, Korea University
2011
Research Assistant Professor, Catholic University of Korea
2010-2011
Massachusetts General Hospital, Harvard Medical School, Boston, MA
2009-2010
Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA
2002-2004
Department of Medicine, University of Massachusetts Medical School, Worcester, MA
Research Keywords: Innate immunity, Lyme disease, hantaviruses
Understanding the pathogenesis of Zika virus infection using animal models.
Immune Network 2017Schlafen 14 (SLFN14) is a novel antiviral factor involved in the control of viral replication.
Immunobiology 2017Whole-genome sequence of Muju virus, an arvicolid rodent-borne hantavirus.
Genome Announcements 2014Hantaviruses induce cell type- and viral species-specific host microRNA expression signatures.
Virology 2013
Satoru Arai, D.V.M., Ph.D.
Senior Researcher
Infectious Disease Surveillance Center
National Institute of Infectious Diseases Tokyo, Japan
Phone: +81-3-5285-1111
Email: arais@nih.go.jp
| 1995 | D.V.M. | (Veterinary Medicine) Rakuno Gakuen University, Hokkaido, Japan |
| 1999 | Ph.D. | (Veterinary Medical Science) Graduate School of Rakuno Gakuen University, Hokkaido, Japan |
| 1999-2004 | Research Staff, Infectious Disease Surveillance Center, National Institute of Infectious Diseases, Tokyo, Japan |
| 2005-present | Senior Researcher, Infectious Disease Surveillance Center, National Institute of Infectious Diseases, Tokyo, Japan |
| 2005-2006 | Visiting Researcher, Department of Tropical Medicine, Medical Microbiology and Pharmacology, John A. Burns School of Medicine, University of Hawaiʻi at Mānoa, Honolulu, HI |
| 2006-2007 | Post Doctoral Fellow, Department of Tropical Medicine, Medical Microbiology and Pharmacology, John A. Burns School of Medicine, University of Hawaiʻi at Mānoa, Honolulu, HI |
Research Keywords: Epidemic infectious diseases, Japanese encephalitis virus, hantaviruses
Genetic diversity of Artybash virus in the Laxmann’s shrew (Sorex caecutiens).
Vector Borne and Zoonotic Diseases 2016Reconstructing the evolutionary origins and phylogeography of hantaviruses.
Trends in Microbiology 2014Molecular phylogeny of hantaviruses harbored by insectivorous bats in Cote d’Ivoire and Vietnam.
Viruses 2014Novel hantavirus in the flat-skulled shrew (Sorex roboratus).
Vector Borne and Zoonotic Diseases 2010Molecular phylogeny of a newfound hantavirus in the Japanese shrew mole (Urotrichus talpoides).
Proceedings of the National Academy of Sciences USA 2008Seewis virus, a genetically distinct hantavirus in the Eurasian common shrew (Sorex araneus).
Virology Journal 2007
Se Hun Gu, Ph.D.
Senior Researcher The 5th R&D Institute 3rd Directorate Agency for Defense Development Yuseong P.O. Box 35 Daejeon, 34188, Korea
Email: sehun.gu@gmail.com
| 2005 | B.S. | Department of Microbiology, Hannam University, Daejeon, Korea |
| 2011 | M.S. | Department of Microbiology, Korea University, Seoul, Korea |
| 2011 | Ph.D. | Department of Microbiology, Korea University, Seoul, Korea |
Research Keywords: Hantavirus, Animal Models
Genetic diversity of Artybash virus in the Laxmann’s shrew (Sorex caecutiens).
Vector Borne and Zoonotic Diseases 2016Whole-genome sequence of a novel hantavirus isolated from the European mole (Talpa europaea).
Genome Announcements 2015Reconstructing the evolutionary origins and phylogeography of hantaviruses.
Trends in Microbiology 2014High prevalence of Nova hantavirus infection in the European mole (Talpa europaea) in France.
Epidemiology and Infection 2014Co-circulation of soricid- and talpid-borne hantaviruses in Poland.
Infection, Genetics and Evolution 2014Molecular phylogeny of hantaviruses harbored by insectivorous bats in Cote d’Ivoire and Vietnam.
Viruses 2014Genetic diversity of Talpa europaea and Nova hantavirus (NVAV) in France.
Bulletin de l'Academie Veterinaire de France 2014Expanded host diversity and geographic distribution of hantaviruses in sub-Saharan Africa.
Journal of Virology 2014Whole-genome sequence of Muju virus, an arvicolid rodent-borne hantavirus.
Genome Announcements 2014Seewis virus, a genetically distinct hantavirus in the Eurasian common shrew (Sorex araneus).
Virology Journal 2007
Shannon N. Bennett, Ph.D.
Associate Curator of Microbiology California Academy of Sciences 55 Music Concourse Drive San Francisco, California 94118
Email: sbennett@calacademy.org
Research Keywords: Evolutionary biology, phylogenetics
Reconstructing the evolutionary origins and phylogeography of hantaviruses.
Trends in Microbiology 2014Seewis virus, a genetically distinct hantavirus in the Eurasian common shrew (Sorex araneus).
Virology Journal 2007
Szu-Chia Hsieh, Ph.D.
Postdoctoral Fellow Institute of Microbiology College of Medicine National Taiwan University Taipei, Taiwan
Email: hsiehsc@hawaii.edu
| 2002 | B.S. | (Entomology) National Taiwan University, Taiwan |
| 2004 | M.S. | (Microbiology) National Taiwan University, Taiwan |
| 2010 | Ph.D. | (Microbiology) National Taiwan University, Taiwan |
Gwong-Jen J. Chang, Ph.D.
Chief
Molecular Epidemiology and Immunochemistry Laboratory
Division of Vector-Borne Diseases
Centers for Disease Control and Prevention, Fort Collins, Colorado
Phone: (970) 221-6497
Email: gxc7@cdc.gov
Human monoclonal antibodies to West Nile virus identify epitopes on the prM protein.
Virology 2011DNA vaccination of American robins (Turdus migratorius) against West Nile virus.
Vector Borne and Zoonotic Diseases 2010
Katherine E. Conant, M.D.
Research Associate Professor
Department of Neuroscience
Georgetown University, Washington, DC
Phone: (202) 687-8614
Email: kec84@georgetown.edu
External Homepage
Marked relationship between matrix metalloproteinase 7 and brain atrophy in HIV infection.
Journal of Neurovirology 2011
Mariano A. Garcia-Blanco, M.D., Ph.D.
Professor
Department of Medicine
Duke University Medical Center, Durham, NC
Phone: (919) 613-8636
Email: garci001@mc.duke.edu
| 1977 | A.B. | (Biochemistry), Harvard College, Cambridge, MA |
| 1984 | M.D. | (Medicine), Yale University, New Haven, CT |
| 1988 | Ph.D. | (Biochemistry), Yale University, New Haven, CT |
| 1987-1990 | Post-Doctoral Fellow | (Molecular Biology), Massachusetts Institute of Technology, Cambridge, MA (Sponsor: Phillip A. Sharp) |
A functional alternative splicing mutation in human tryptophan hydroxylase-2.
Molecular Psychiatry 2011Factors affecting reproducibility between genome-scale siRNA-based screens.
Journal of Biomolecular Screening 2010Alternative splicing in multiple sclerosis and other autoimmune diseases.
RNA Biology 2010SplicerAV: a tool for mining microarray expression data for changes in RNA processing.
BMC Bioinformatics 2010
William C. Nierman, Ph.D.
Infectious Diseases Investigator
J. Craig Venter Institute
Professor
Department of Biochemistry and Molecular Biology
George Washington University School of Medicine, Washington, DC
Phone: (301) 795-7559
Email: wnierman@jcvi.org
External Homepage
Structural analysis of the Rhizoctonia solani agglutinin reveals a domain-swapping dimeric assembly.
FEBS Journal 2013Draft genome sequences of Burkholderia cenocepacia ET12 lineage strains K56-2 and BC7.
Genome Announcements 2013Sequence Determination of Burkholderia pseudomallei Strain NCTC 13392 Colony Morphology Variants.
Genome Announcements 2013Cryptococcus gattii comparative genomics and transcriptomics: A NIH/NIAID white paper.
Mycopathologia 2011Comparative genomic analysis of fruiting body formation in Myxococcales.
Molecular Biology and Evolution 2011Transcript amplification from single bacterium for transcriptome analysis.
Genome Research 2011Identification and characterization of an Aspergillus fumigatus “supermater” pair.
mBio 2011Characterization of a 5-azacytidine-induced developmental Aspergillus fumigatus variant.
Virulence 2010Aspergillus fumigatus AcuM regulates both iron acquisition and gluconeogenesis.
Molecular Microbiology 2010Continuing evolution of Burkholderia mallei through genome reduction and large-scale rearrangements.
Genome Biology and Evolution 2010Genetic and phenotypic diversity in Burkholderia: contributions by prophage and phage-like elements.
BMC Microbiology 2010The early stage of bacterial genome-reductive evolution in the host.
PLoS Pathogens 2010
Alexandra Gurary, Ph.D.
Associate Director, Molecular and Cellular Immunology Core\
Dengue virus, flow cytometry
Office:
Phone: (808) 692-1794
Email: gurary@hawaii.edu
| 1984 | B.S. | (Chemistry/Mathematics) University of Maryland, College Park, MD |
|---|---|---|
| 2004 | B.S. | (Chemistry) University of Hawaiʻi at Mānoa, Honolulu, HI |
| 2014 | Ph.D. | (Tropical Medicine) University of Hawaiʻi at Mānoa, Honolulu, HI |
George S.N. Hui, Ph.D.
Director, Molecular and Cellular Immunology Core
Professor
Department of Tropical Medicine, Medical Microbiology and Pharmacology
John A. Burns School of Medicine
Phone: 808-692-1609
Office: BSB 320K
Email: ghui@hawaii.edu
| 1987 - 1991 | Assistant Research Professor, Department of Tropical Medicine, University of Hawaiʻi at Mānoa |
| 1991 - 1996 | Associate Research Professor, Department of Tropical Medicine, University of Hawaiʻi at Mānoa |
| 1995 - 1996 | NIH-TMRC Visiting Scientist, Research Institutes for Tropical Medicine, Philippines |
| 1996 - present | Research Professor (with tenure), Department of Tropical Medicine, University of Hawaiʻi at Mānoa |
| 1991 - 2000 | American Society of Tropical Medicine & Hygiene, member |
| 1994 - 1996 | American Society of Tropical Medicine & Hygiene, Scientific Program Committee |
| 1994 - 1996 | Chairperson, University of Hawaiʻi, System-wide Animal Care and Use Committee |
| 1998 | Ad hoc Consultant, Trop.Diseases Res. (TDR), WHO, Vaccine Discovery Research |
| 1997 - 1999 | University of Hawaiʻi Committee on Human Subjects (IRB) |
| 1999 | External grant review consultant for the Austrian Science Fund |
| 1999 - present | Consultant, Hawaiʻi Biotechnology Inc. |
| 2005 - present | Consultant, Neugenesis Inc. |
| 2008 | President. American Society for Microbiology, Hawaiʻi Branch |
| 2009-present | External consultant for AIBS, Military Malaria Vaccine Program |
| 1999 | NIAID/NIH, Tropical Medicine & Parasitology (TMP) Special Study Section for RFA |
| 1997, 2000, 02-03 | NIAID/NIH, Vaccine Study Section (VAC 01, VAC 04, VAC 10) |
| 2003 | NIAID/NIH, SEP, Member of parent panel, and Sub-committee Chair, Regional Centers of Excellence for Biodefense and Emerging Infectious Diseases (RCE) |
| 2004 | NIAID, SEP, Operation of a Facility for Testing of Malaria Vaccines in Adult Human Subjects |
| 2006 | CSR/NIH, ZRG1 IMM-K (13) B, Influenza Vaccine Development |
| 2006 | NIAID/NIH, ZAI1-MH-M-C2. Malaria Vaccine Production and Support Services |
| 2004 - 2009 | CSR/NIH, Vaccines for Microbial Diseases (VMD) |
| 2010 | NIAID/NIH, ZAI1 AWA-M, M2. SEP. International Center of Excellence for Malaria Research |
| CSR/NIH, ZRG1 IMM-G 12B Small Business Grant Microbial Vaccine Development | |
| 2010 - 2011 | CSR/NIH, ZRG1 ZRG1 IMM-F07-C(20)L B cell Regulation & Tolerance to Cancer Antigens |
| 2011 | CSR/NIH, Bioengineering & Biosciences IRG, Biomaterials and Biointerfaces |
| CSR/NIH, ZRG1 IMM-K(02)M, Immunology |
Research Keywords: Malaria, vaccine, adjuvant
My research is on the development of blood stage malaria vaccines; and studies on the use of different vaccine adjuvants for the malaria vaccines. Specifically, we focus on the design of vaccines based on the Merozoite Surface Protein 1 (MSP1) by defining critical T and B epitopes of the molecule. We also evaluate the use of a variety of immunological adjuvants to enhance vaccine potency and at the same time define the critical pathway for adjuvants’ mode of action. Our approaches also study the use of nanoparticle platforms for antigen delivery.
Beside research, I am also the director of a biomedical sciences research training program for high school and college bound students called the STEP-UP Program (http://stepup.niddk.nih.gov) that is supported by NIDDK/NIH. The project recruits minority and disadvantage students from the Pacific Regions, Alaska and Puerto Rico into university/college research laboratories to engage in health related research under the mentorships of university faculty.
Training the next generation of minority health scientists: a STEP-UP in the right direction.
Hawaii Medical Journal 2011
Mahdi Belcaid, Ph.D.
Associate Director, Bioinformatics Core Assistant Researcher, Hawaiʻi Institute of Marine Biology School of Ocean and Earth Science and Technology
Phone: 808-956-6049
Office: POST310A
Email: mahdi@hawaii.edu
| 2001 | B.S. | (Computer Science) University of Quebec at Montreal, Canada |
| 2006 | M.S. | (Computer Science) University of Quebec at Montreal, Canada |
| 2012 | Ph.D. | (Computer Science) University of Hawaiʻi at Mānoa, Honolulu, HI |
Comparative genomics explains the evolutionary success of reef-forming corals.
Elife 2016Complete genome sequence of Burkholderia cepacia strain LO6.
Genome Announcements 2015Preclinical development of HIvax: Human survivin highly immunogenic vaccines.
Human Vaccines and Immunotherapeutics 2015The characterization of RNA viruses in tropical seawater using targeted PCR and metagenomics.
MBio 2014Chimeric piggyBac transposases for genomic targeting in human cells.
Nucleic Acids Research 2012Efficient clustering of populations using a minimal SNP panel.
Proceedings of the 2011 ACM Symposium on Applied Computing 2011The evolution of the tape measure protein: units, duplications and losses.
BMC Bioinformatics 2011Mosaic graphs and comparative genomics in phage communities.
Journal of Computational Biology 2010Virus DNA-fragment classification using taxonomic hidden Markov model profile.
Proceedings of the 2010 ACM Symposium on Applied Computing 2010Divide and conquer: enriching environmental sequencing data.
PLoS One 2007
Mukesh Kumar, Ph.D.
Associate Director, Biocontainment Core
Assistant Professor
Department of Tropical Medicine, Medical Microbiology and Pharmacology
John A. Burns School of Medicine
Phone: (808) 692-1671
Email: mukesh@hawaii.edu
| 2007 | B.V.Sc. & A.H. | (Veterinary Science) College of Verterinary Science and Animal Husbandry, Jabalpur, India |
| 2010 | M.S. | (Biomedical Sciences) University of Hawaiʻi at Mānoa, Honolulu, HI |
| 2013 | Ph.D. | (Biomedical Sciences) University of Hawaiʻi at Mānoa, Honolulu, HI |
Research Keywords: Flaviviruses, pathogenesis, animal models
Recombinant Zika virus subunits are immunogenic and efficacious in mice.
mSphere 2018Understanding the pathogenesis of Zika virus infection using animal models.
Immune Network 2017Schlafen 14 (SLFN14) is a novel antiviral factor involved in the control of viral replication.
Immunobiology 2017Clinical and imaging findings in an infant with Zika embryopathy.
Clinical Infectious Diseases 2016In vitro and in vivo blood-brain barrier models to study West Nile virus pathogenesis.
Methods in Molecular Biology 2016Hantaviruses induce cell type- and viral species-specific host microRNA expression signatures.
Virology 2013
Vivek R. Nerurkar, Ph.D.
Director, Biocontainment Core
Professor and Chair
Department of Tropical Medicine, Medical Microbiology and Pharmacology
John A. Burns School of Medicine
Phone: 808-692-1668
Office: BSB 320G
Email: nerurkar@hawaii.edu
External Homepage
| 1980 | B.Sc. Biology, Chemistry, Physics; First Class | University of Bombay, Bombay, India |
| 1981 | D.M.L.T. Diploma in Medical Laboratory Technology | University of Bombay, Bombay, India |
| 1983 | M.Sc. Zoology (Animal Physiology); First Class | University of Bombay, Bombay, India |
| 1987 | Ph.D. Applied Biology (Cell and Molecular Biology) | Comparative Oncology Unit, Cancer Research Institute, University of Bombay, Bombay, India |
| 1981 | Technical Assistant, Department of Pathology and Clinical Biochemistry, Lokmanaya Tilak Medical College and Hospital, Bombay, India |
| 1981 - 1983 | Technical Assistant, Indian Red Cross, Bombay, India |
| 1987 | Research Associate, Department of Cell and Developmental Pathology, Cancer Research Institute, Bombay, India |
| 1987 - 1989 | Research Associate, Cancer Center, University of Rochester, Rochester, New York |
| 1989 | Postdoctoral Fellow, Department of Biological Sciences, State University of New York at Buffalo, Buffalo, New York |
| 1989 - 1992 | Visiting Fellow, Fogarty International Center (FIC), Laboratory of Central Nervous System Studies (LCNSS), National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH), Bethesda, Maryland |
| 1992 - 1993 | Visiting Associate, FIC, LCNSS, NINDS, NIH, Bethesda, Maryland |
| 1993 - 1994 | Guest Researcher, FIC, LCNSS, NINDS, NIH, Bethesda, Maryland |
| 1994 - 1996 | Assistant Researcher (Virology), Retrovirology Research Laboratory (RRL), Pacific Biomedical Research Center (PBRC), University of Hawaiʻi at Mānoa (UHM), Honolulu, Hawaiʻi |
| 1995 | Acting Director, RRL, PBRC, UHM, Honolulu, Hawaiʻi |
| 1996 - 2000 | Associate Professor, Interdisciplinary Biomedical Sciences Graduate Program, UHM, Honolulu, Hawaiʻi |
| 1996 - 2003 | Associate Researcher (Virology), RRL, PBRC, UHM, Honolulu, Hawaiʻi |
| 1998 - 1999 | Associate Professor, Department of Epidemiology, School of Public Health, UHM, Honolulu, Hawaiʻi |
| 1999 - 2003 | Associate Professor, Department of Public Health Sciences and Epidemiology, John A. Burns School of Medicine (JABSOM), UHM, Honolulu, Hawaiʻi |
| 2000 - 2003 | Associate Professor, Cell and Molecular Biology (CMB) Graduate Program, and Tropical Medicine and Medical Microbiology (TMMM) Graduate Program, JABSOM, UHM, Honolulu, Hawaiʻi |
| 2001 - 2003 | Associate Professor, Microbiology Department Graduate Program, College of Natural Sciences, UHM, Honolulu, Hawaiʻi |
| 2001 - 2006 | Activity Leader, Pathobiology of HIV-Associated Disorders, NIH-NCRR Research Centers in Minority Institutions (RCMI) Program, JABSOM, UHM, Honolulu, Hawaiʻi |
| 2002 - 2003 | Associate Professor, Molecular Biosciences and Biosystems Engineering (MBBE) Graduate Program, College of Tropical Agriculture and Human Resources UHM, Honolulu, Hawaiʻi |
| 2002 - 2004 (Sept) | Member, PBRC Executive Committee, PBRC, UHM, Honolulu, Hawaiʻi |
| 2002 - Present | Director, RRL, PBRC/JABSOM, UHM, Honolulu, Hawaiʻi |
| 2003 (July) | Researcher (Virology), RRL, PBRC, UHM, Honolulu, Hawaiʻi |
| 2003 (Sept) - Present | Professor, Department of Tropical Medicine and Medical Microbiology, JABSOM, UHM, Honolulu, Hawaiʻi |
| 2003 - Present | Professor, Microbiology, CMB, MBBE, TMMM, and Epidemiology Graduate Programs, UHM, Honolulu, Hawaiʻi |
| Director Technical Core, Pacific Center for Emerging Infectious Diseases Research, Center of Biomedical Research Excellence NIH-NCRR, JABSOM, UHM, Honolulu, Hawaiʻi | |
| 2005 (July) - Present | Professor (Tenured), Department of Tropical Medicine, Medical Microbiology and Pharmacology, JABSOM, UHM, Honolulu, Hawaiʻi |
| 2006 - 2008 | Associate Activity Leader, Tropical Infectious Diseases Detection and Prevention Core (TDDPC) activity, NIH-NCRR RCMI, JABSOM, UHM, Honolulu, Hawaiʻi |
| 2008 (Aug) - Present | Activity Leader, TDDPC activity, NIH-NCRR RCMI Program, JABSOM, UHM, Honolulu, Hawaiʻi |
| 2008 (Nov) - Present | Interim Chair, Department of Tropical Medicine, Medical Microbiology and Pharmacology, JABSOM, UHM, Honolulu, Hawaiʻi |
| 2009 - 2010 | President-Elect, Amercian Society for Microbiology Hawaii Chapter, Honolulu, Hawaiʻi |
| 2009 (Feb) - Present | Director, Biocontainment Facility, JABSOM, UHM, Honolulu, Hawaiʻi |
| 2010 (Jan) - Present | Chair, Department of Tropical Medicine, Medical Microbiology and Pharmacology, JABSOM, UHM, Honolulu, Hawaiʻi |
| 2010 (April) - Present | President, Amercian Society for Microbiology Hawaii Chapter, Honolulu, Hawaiʻi |
Research Keywords: Molecular virology, arbovirology, viral diagnostics
Dr. Vivek R. Nerurkar, who joined the University of Hawaiʻi at Mānoa (UHM) in 1994, to develop the Research Centers in Minority Institutions (RCMI), NCRR-supported Retrovirology Activity following a five-year appointment as a Visiting Fellow and Visiting Associate of the NINDS, NIH, has mentored over 100 undergraduate and graduate students, technicians and postdoctoral fellows in laboratory-based research during the past 25 years. Dr. Nerurkar’s major area of research interest is in infectious diseases, specifically to study the pathogenesis of orphan diseases and orphan microbial agents. Over the past two decades he has conducted research in the diverse but related areas of virology, specifically neurovirology.
Dr. Nerurkar conducts research on pathogenesis of West Nile virus-associated meningoencephalitis and pathogenesis of the fatal demyelinating disease, progressive multifocal leukoencephalopathy (PML). A talented virologist, Dr. Nerurkar, has extensive experience in classical and molecular microbiological techniques, as documented in publications appearing in peer-reviewed journals and in successful grant applications from local and national agencies. He has utilized molecular methods to study a wide range of emerging and re-emerging microbial pathogens. Dr. Nerurkar has collaborated nationally and internationally with investigators from various ethnic backgrounds. He has extensive experience of conducting research in international arena and his abilities to train minority students, enrolled at the UHM (a minority institution) and international students and postdoctoral fellows, is well documented in the form of collaborative publications. He is member of the graduate faculty of the Department of Cell and Molecular Biology (CMB), JABSOM; Department of Molecular Biosciences and Biosystems Engineering (MBBE), College of Tropical Agriculture and Human Resources (CTAHR); and Department of Microbiology, College of Natural Sciences (CNS), UHM. He is part of the NIH Short Term Education Program for Underrepresented Persons (STEP UP) Summer program, which trains high school and undergraduate students in laboratory research. He is also a mentor of the NIMH, NIH R25 grant, which trains minorities and other disadvantaged students and faculty in conducting research on mental health related issues. Dr. Nerurkar will serve as a Core Director and Mentor on this proposal.
PCR-based detection of Plasmodium falciparum in saliva using mitochondrial cox3 and varATS primers.
Tropical Medicine and Health 2018Recombinant Zika virus subunits are immunogenic and efficacious in mice.
mSphere 2018Prevalence of malaria, typhoid, toxoplasmosis and rubella among febrile children in Cameroon.
BMC Infectious Diseases 2016Clinical and imaging findings in an infant with Zika embryopathy.
Clinical Infectious Diseases 2016Functional analysis of West Nile virus proteins in human cells.
Methods in Molecular Biology 2016In vitro and in vivo blood-brain barrier models to study West Nile virus pathogenesis.
Methods in Molecular Biology 2016Evidence for a “founder effect” among HIV-infected injection drug users (IDUs) in Pakistan.
BMC Infectious Diseases 2010In vitro effects of selenium deficiency on West Nile virus replication and cytopathogenicity.
Virology Journal 2008Professor & Lead Bioinformatician Director of Bioinformatics Core
Phone: 6921664
Email: dengy@hawaii.edu
Ph.D.
Peking Union Medical College and Chinese Academy of Medical Sciences
Beijing, China
Plasma small ncRNA pair panels as novel biomarkers for early-stage lung adenocarcinoma screening.
BMC Genomics 2018The evaluation of serum biomarkers for non-small cell lung cancer (NSCLC) diagnosis.
Frontiers in Physiology 2018Increased AURKA promotes cell proliferation and predicts poor prognosis in bladder cancer.
BMC Systems Biology 2018
David A. Relman, M.D.
Thomas C. and Joan M. Merigan Professor Professor of Medicine Professor of Microbiology and Immunology Co-director of the Center for International Security and Cooperation Stanford University School of Medicine Stanford, California
Email: relman@stanford.edu
Dr. Relman’s primary research focus is the human indigenous microbiota (microbiome), and in particular, the nature and mechanisms of variation in patterns of microbial diversity and function within the human body, and the basis of microbial community resilience. His work was some of the first to employ modern molecular methods in the study of the microbiome, and provided the first in-depth sequence-based analyses of microbial community structure in humans. During the past few decades, his research has included pathogen discovery and the development of new strategies for identifying previously-unrecognized microbial agents of disease. A resulting publication was cited by the American Society for Microbiology as one of the 50 most important papers in microbiology of the twentieth century. He has also served as an advisor to a number of agencies and departments within the U.S. Government on matters pertaining to host-microbe interactions, emerging infectious diseases, and biosecurity. He co-chaired a widely-cited 2006 study by the National Academies of Sciences (NAS) on Globalization, Biosecurity, and the Future of the Life Sciences, and served as vice-chair of a 2011 National Academies study of the science underlying the FBI investigation of the 2001 anthrax mailings. He currently serves as a member of the National Science Advisory Board for Biosecurity (2005-), a member of the Committee on Science, Technology, and Law at the National Academy of Science (2012-15), a member of the Science, Technology & Engineering Advisory Panel for Lawrence Livermore National Laboratory (2012-), as Chair of the Forum on Microbial Threats at the Institute of Medicine (NAS) (2007-), and as President of the Infectious Diseases Society of America (2012-2013).
Dr. Relman received an S.B. (Biology) from MIT (1977), M.D. (magna cum laude) from Harvard Medical School (1982), completed his clinical training in internal medicine and infectious diseases at Massachusetts General Hospital, served as a postdoctoral fellow in microbiology at Stanford University, and joined the faculty at Stanford in 1994. He received an NIH Director’s Pioneer Award in 2006, was elected a Fellow of the American Academy of Microbiology in 2003 and the American Association for Advancement of Science in 2010, and was elected a Member of the Institute of Medicine in 2011.
Marine mammals harbor unique microbiotas shaped by and yet distinct from the sea.
Nature Communications 2016Temporal and spatial variation of the human microbiota during pregnancy.
Proceedings of the National Academy of Sciences U S A 2015SCIENCE GOVERNANCE. A more systematic approach to biological risk.
Science 2015Actionable sequence data on infectious diseases in the clinical workplace.
Clinical Chemistry 2015
Diane E. Griffin, M.D., Ph.D.
University Distinguished Service Professor
W. Harry Feinstone Department of Molecular Microbiology and Immunology
Johns Hopkins Bloomberg School of Public Health Baltimore, Maryland
Phone: (410) 955-3459
Email: dgriffin@jhsph.edu
Neurotropic virus infections as the cause of immediate and delayed neuropathology.
Acta Neuropathologica 2016Replication of many human viruses is refractory to inhibition by endogenous cellular microRNAs.
Journal of Virology 2014Interleukin 10 modulation of pathogenic Th17 cells during fatal alphavirus encephalomyelitis.
Proceedings of the National Academy of Sciences U S A 2014Prolonged persistence of measles virus RNA is characteristic of primary infection dynamics.
Proceedings of the National Academy of Sciences U S A 2012Recovery from viral encephalomyelitis: immune-mediated noncytolytic virus clearance from neurons.
Immunological Research 2010Emergence and re-emergence of viral diseases of the central nervous system.
Progress in Neurobiology 2010Dynamic regulation of functionally distinct virus-specific T cells.
Proceedings of the National Academy of Sciences USA 2010
Richard J. Kuhn, Ph.D.
Professor and Head
Department of Biological Sciences
Gerald and Edna Mann Director
Bindley Bioscience Center
Purdue University West Lafayette, Indiana
Phone: (765) 494-4407
Email: kuhnr@purdue.edu
Genomic insights into the Ixodes scapularis tick vector of Lyme disease.
Nature Communications 2016Structure-guided insights on the role of NS1 in flavivirus infection.
Bioessays 2015Structure and inhibition of EV-D68, a virus that causes respiratory illness in children.
Science 2015Structure of acidic pH dengue virus showing the fusogenic glycoprotein trimers.
Journal of Virology 2015Flavivirus NS1 structures reveal surfaces for associations with membranes and the immune system.
Science 2014Neutralizing antibodies can initiate genome release from human enterovirus 71.
Proceedings of the National Academy of Sciences USA 2014West Nile virus methyltransferase domain interacts with protein kinase G.
Virology Journal 2013Structure of human enterovirus 71 in complex with a capsid-binding inhibitor.
Proceedings of the National Academy of Sciences U S A 2013Dengue structure differs at the temperatures of its human and mosquito hosts.
Proceedings of the National Academy of Sciences USA 2013Dengue virus infection perturbs lipid homeostasis in infected mosquito cells.
PLoS Pathogens 2012Detection of membrane protein two-dimensional crystals in living cells.
Biophysics Journal 2011A physical interaction network of dengue virus and human proteins.
Molecular and Cellular Proteomics 2011Design, synthesis, and biological evaluation of thiazoles targeting flavivirus envelope proteins.
Journal of Medicinal Chemistry 2011Maturation of flaviviruses starts from one or more icosahedrally independent nucleation centres.
EMBO Reports 2011Rescue of infectious particles from preassembled alphavirus nucleocapsid cores.
Journal of Virology 2011Molecular links between the E2 envelope glycoprotein and nucleocapsid core in Sindbis virus.
Journal of Molecular Biology 2011Influence of pr-M cleavage on the heterogeneity of extracellular dengue virus particles.
Journal of Virology 2010Crystallization and preliminary X-ray diffraction analysis of West Nile virus.
Acta Crystallographica Section F: Structural Biology and Crystallization Communications 2010Structural changes of envelope proteins during alphavirus fusion.
Nature 2010Association of the pr peptides with dengue virus at acidic pH blocks membrane fusion.
Journal of Virology 2009
Angel A. Yanagihara, Ph.D.
Associate Research Professor
Department of Tropical Medicine, Medical Microbiology and Pharmacology
John A. Burns School of Medicine
Cnidaria, Irukandji Syndrome
Office: (808) 956-8328
Email: ayanagih@hawaii.edu
| 1982 | B.A. | (Biology) University of Virginia, Charlottesville, Virginia |
|---|---|---|
| 1982 | B.A. | (Chemistry) University of Virginia, Charlottesville, Virginia |
| 1997 | Ph.D. | (Cell and Molecular Neuroscience) University of Hawaiʻi at Mānoa, Honolulu, HI |
Biochemistry, Marine Toxinology
Research Keywords: Cnidaria, Irukandji Syndrome
Axel Lehrer, Ph.D.
Assistant Professor
Department of Tropical Medicine, Medical Microbiology and Pharmacology
John A. Burns School of Medicine
Office: BSB 320B
Email: lehrer@hawaii.edu
| 1998 | M.Sc. | (Biochemistry) University of Bayreuth, Germany |
| 2001 | Ph.D. | (Biology) University of Bayreuth, Germany |
Vaccinology, Molecular Virology
| 2011-present | American Society of Microbiology |
| 2002-present | American Society for Biochemistry and Molecular Biology |
| 2004-2010 | American Society for Tropical Medicine and Hygiene |
Research Keywords: Ebola, filoviruses
A recombinant subunit based Zika virus vaccine is efficacious in non-human primates.
Frontiers in Immunology 2018Recombinant Zika virus subunits are immunogenic and efficacious in mice.
mSphere 2018Ebola virus glycoprotein induces an innate immune response in vivo via TLR4.
Frontiers in Microbiology 2017
James F. Kelley, Ph.D.
Assistant Professor
Department of Tropical Medicine, Medical Microbiology and Pharmacology
John A. Burns School of Medicine
Email: jkelley@hawaii.edu
Research Keywords: Dengue
Mukesh Kumar, Ph.D.
Associate Director, Biocontainment Core
Assistant Professor
Department of Tropical Medicine, Medical Microbiology and Pharmacology
John A. Burns School of Medicine
Phone: (808) 692-1671
Email: mukesh@hawaii.edu
| 2007 | B.V.Sc. & A.H. | (Veterinary Science) College of Verterinary Science and Animal Husbandry, Jabalpur, India |
| 2010 | M.S. | (Biomedical Sciences) University of Hawaiʻi at Mānoa, Honolulu, HI |
| 2013 | Ph.D. | (Biomedical Sciences) University of Hawaiʻi at Mānoa, Honolulu, HI |
Research Keywords: Flaviviruses, pathogenesis, animal models
Recombinant Zika virus subunits are immunogenic and efficacious in mice.
mSphere 2018Understanding the pathogenesis of Zika virus infection using animal models.
Immune Network 2017Schlafen 14 (SLFN14) is a novel antiviral factor involved in the control of viral replication.
Immunobiology 2017Clinical and imaging findings in an infant with Zika embryopathy.
Clinical Infectious Diseases 2016In vitro and in vivo blood-brain barrier models to study West Nile virus pathogenesis.
Methods in Molecular Biology 2016Hantaviruses induce cell type- and viral species-specific host microRNA expression signatures.
Virology 2013
Pakieli Kaufusi, Ph.D.
Assistant Professor
Department of Tropical Medicine, Medical Microbiology and Pharmacology
John A. Burns School of Medicine
Office: BSB 320
Email: pakieli@hawaii.edu
| 1990 | B.A. | (Chemistry) University of the South Pacific, Suva, Fiji |
| 1997 | M.Sc. | (Molecular Virology) University of Hawaiʻi at Mānoa, Honolulu, Hawaiʻi |
| 2005 | Ph.D. | (Molecular Biotechnology & Bacterial Genetics) University of Hawaiʻi at Mānoa, Honolulu, Hawaiʻi |
Research Keywords: Flavivirus replication
Functional analysis of West Nile virus proteins in human cells.
Methods in Molecular Biology 2016
Saguna Verma, Ph.D.
Associate Professor
Department of Tropical Medicine, Medical Microbiology and Pharmacology
John A. Burns School of Medicine
Phone: 808-692-1662
Office: BSB 325C
Email: saguna@hawaii.edu
| 1985 | B.S. | (Zoology, Chemistry, Botany) Devi Ahilya University, Indore, India |
| 1988 | M.S. | (Biochemistry) Devi Ahilya University, Indore, India |
| 1994 | Ph.D. | (Biochemistry) Devi Ahilya University, Indore, India |
| 1989-1991 | Junior Research Fellow, School of Life Sciences, Indore, India |
| 1992-1993 | Senior Research Fellow, School of Life Sciences, Indore, India |
| 1994-1999 | Project Scientist, Genes and Proteins Laboratory, National Institute of Immunology, New Delhi, India |
| 2000-2001 | Guest Lecturer, Vaid’s Institute, New Delhi, India |
| 2003-2005 | Junior Researcher, Retrovirology Research Laboratory, Department Tropical Medicine, Medical Microbiology and Pharmacology, John A. Burns School of Medicine, University of Hawaiʻi at Mānoa, Honolulu, Hawaiʻi |
| 2005-present | Assistant Professor, Department Tropical Medicine, Medical Microbiology and Pharmacology, John A. Burns School of Medicine, University of Hawaiʻi at Mānoa, Honolulu, Hawaiʻi |
| 1985 | Merit Scholarship in B.Sc. by the Devi Ahilya University, Indore, India |
| 1989-1993 | University Grants Commission-Council of Science and Industrial Research (UGC-CSIR) and Lecturer Eligibility Fellowship, India |
| 1992 | Madhya Pradesh Council of Science and Technology, India (MPCST) YOUNG SCIENTIST, Merit certificate in 7th Young Scientist conference organized by Council of Science and Technology, India |
| 1992 | Travel Award from CSIR, India, to attend the annual meeting of the Federation of American Societies for Experimental Biology, Anaheim, CA |
| 2004 | Travel Award from the Retrovirology and Opportunistic Infections Society to attend the Eleventh Conference on Retroviruses and Opportunistic Infections, San Francisco, CA |
| 2005 | Hawaii State-Biomedical Research Infrastructure Network (BRIN) Travel Award to attend the Eighth International Symposium on Kawasaki Disease, San Diego, CA |
Research Keywords: Neurovirology, neuroinflammation, West Nile virus, flaviviruses
Ebola virus glycoprotein induces an innate immune response in vivo via TLR4.
Frontiers in Microbiology 2017Triggering receptor expressed on myeloid cells-1 (TREM-1): a new player in antiviral immunity?
Frontiers in Microbiology 2014In vitro effects of selenium deficiency on West Nile virus replication and cytopathogenicity.
Virology Journal 2008
Sandra P. Chang, Ph.D.Professor
Department of Tropical Medicine, Medical Microbiology and Pharmacology
John A. Burns School of Medicine
Phone: 808-692-1607
Office: JABSOM BSB 320H
Email: sandrac@hawaii.edu
| 1973 | B.S. | (Biology) University of Hawaiʻi at Mānoa, Honolulu, Hawaiʻi |
| 1977 | M.S. | (Microbiology) University of Hawaiʻi at Mānoa, Honolulu, Hawaiʻi |
| 1983 | Ph.D. | (Microbiology and Immunology) Oregon Health Sciences University, Portland, Oregon |
1983-1986 Post-doc (Molecular Biology) California Institute of Technology, Pasadena, California
1986-1988 Assistant Researcher, Department of Tropical Medicine and Medical Microbiology, John A. Burns School of Medicine, University of Hawaiʻi
1988 1995 Associate Researcher, Department of Tropical Medicine and Medical Microbiology, John A. Burns School of Medicine, University of Hawaiʻi
1995-1997 Associate Professor, Department of Tropical Medicine and Medical Microbiology, John A. Burns School of Medicine, University of Hawaiʻi
1997-present Professor, Department of Tropical Medicine and Medical Microbiology, John A. Burns School of Medicine, University of Hawaiʻi
Research Keywords: Malaria, vaccine, adjuvants
Malaria is a major cause of global morbidity and mortality in tropical countries and most notably among infants, young children and pregnant women in sub-Saharan Africa. Our long term goal is to develop a safe and effective blood stage vaccine directed against merozoite surface protein-1 (MSP1), a major coat protein of P. falciparum merozoites. This goal requires development of two essential components of a malaria vaccine, (i) the production of an optimally immunogenic antigen capable of inducing a protective immune response, and (ii) the identification of an immunostimulatory and non-toxic adjuvant formulation that may be combined with this antigen to generate protective immunity to falciparum malaria. Previous studies in this laboratory have focused on developing a baculovirus recombinant 42 kDa MSP1 C-terminal polypeptide which is highly immunogenic and induces protection in a non-human primate model of P. falciparum malaria. One of our current research objectives is to improve the protective immune response to a P. falciparum MSP1-based malaria vaccine by combining sequences located within MSP1 blocks 4, 16, and 17 to induce protective immune responses to multiple MSP1 epitopes. Our second research objective is to evaluate the ability of a series of well-defined immunomodulators to stimulate an immune response to MSP1 with in vitro and in vivo biological activities against P. falciparum blood stages. We hypothesize that a multi-epitope MSP1 antigen formulated with specific combinations of TLR (Toll-like receptor) and NOD (nucleotide-binding oligomerization domain-like receptor) agonists will be effective in inducing a protective immune response to P. falciparum infection.
Specific Aim 1
Shift in epitope dominance of IgM and IgG responses to Plasmodium falciparum MSP1 block 4.
Malaria Journal 2010Comparison of immunogenicity of five MSP1-based malaria vaccine candidate antigens in rabbits.
Vaccine 2009
Tung T. Hoang, Ph.D.
Professor
Department of Microbiology
College of Natural Sciences
Phone: 808-956-3522
Office: Snyder Hall 308
Email: tongh@hawaii.edu
| 1994 | B.Sc. | Biochemistry, University of Calgary, Calgary, Alberta, Canada |
| 1996 | M.Sc. | Microbiology and Infectious Diseases, University of Calgary, Calgary, Alberta, Canada |
| 2000 | Ph.D. | Microbiology, Colorado State University, Fort Collins, Colorado |
Bacterial Genetics and Molecular Pathogenesis
Research Keywords: Burkholderia pseudomallei, transcriptome analysis, intracellular pathogenesis
For the past few years, I have been fascinated and passionate about the pathophysiology of B. pseudomallei, which causes a disease called melioidosis. Born and raised in Vietnam during the war and running around in rice fields where the bacterium is found, I never realized the importance of this bacterium until recently. My lab has worked with B. pseudomallei for the past three years engineering and publishing several molecular genetic tools for the scientific community. The lab currently researches the molecular pathogenesis of B. pseudomallei during its infection within host-cells. Our hypothesis is that B. pseudomallei, as it encounters and senses uniquely different intracellular environments and performs sequential steps in the infection process, will undergo differential gene expression at each stage of intracellular cycle. We pioneered and studied global transcriptional profiling of single B. pseudomallei cells as it transit through the host cell, which we cumulatively named a “transitome.” Our goal is to more clearly identify the genes, and hence the proteins, required for eukaryotic hosts’ cellular infection in each spatially defined infectious stage (vesicle, cytoplasm, and membrane protrusion). Ultimately, understanding the function of these virulence genes and mechanisms of infection and disease at the molecular level will aid in rational drug and vaccine design. My short journey of escaping Vietnam at the age of 10 to being a refugee in Thailand, immigrated to Canada with not a word of English, obtained my PhD at Colorado State University and now back to studying a potential bioterrorism agent found in rice fields throughout Southeast Asia has come full circle, with full of passion and enjoyment for this research to help people inflicted with melioidosis.
Spatial transcriptomes within the Pseudomonas aeruginosa biofilm architecture.
Molecular Microbiology 2017Complete genome sequence of Burkholderia cepacia strain LO6.
Genome Announcements 2015Transcript amplification from single bacterium for transcriptome analysis.
Genome Research 2011Stable, site-specific fluorescent tagging constructs optimized for Burkholderia species.
Applied and Environmental Microbiology 2010Genetic tools for allelic replacement in Burkholderia species.
Applied and Environmental Microbiology 2008
Wei-Kung Wang, M.D., Sc.D.Professor
Department of Tropical Medicine, Medical Microbiology and Pharmacology
John A. Burns School of Medicine
Phone: 808-692-1667
Office: BSB 320E
Email: wwang60@yahoo.com
| 1986 | M.D. | Medicine, National Taiwan University, Taipei, Taiwan |
| 1995 | Sc.D. | Virology, Harvard School of Public Health, Boston, Massachusetts |
Molecular Virology and Viral Pathogenesis
Research Keywords: Dengue virus, envelope protein, precursor membrane protein, virus-like particles, antibody response
Dr. Wang’s lab has been studying virus-host interaction and disease pathogenesis of dengue virus (DENV). His lab showed that the level and rate of decline of dengue viral load and virus-containing immune complexes correlate with disease severity (Wang et al., 2003, Virology; 2006, Clin. Infect. Dis.). And his lab reported for the first time the quasispecies nature of DENV in human (Wang et al., 2002, J. Virol.) and mosquito (Lin et al., 2004, J. Virol), which provides new insight into our understanding of the evolutionary conservation of DENV.
Recently, his research focused on the antibody responses to DENV envelope (E) protein during the natural course of infection; his lab reported that the majority of anti-E antibodies is cross-reactive and recognizes highly conserved residues at the fusion loop of domain II (Lai et al., 2008, J. Virol.). These findings not only provided a molecular evidence to explain the flavivirus cross-reactivity that has been known for decades, but also have implications to our understanding our the pathogenesis of dengue and future design of subunit vaccines against DENV.
His research also focused on the functions of precursor membrane (prM)/E proteins of DENV and formation of virus-like particles (VLPs). His lab discovered the ER retention signal and critical elements of the stem-anchor region of DENV E protein. (Hsieh et al., 2008, Virology; 2010, J. Virol.), and reported that the helical domains of the stem regions of prM and E proteins are involved in both assembly and entry, two important steps of the replication cycles of DENV (Hsieh et al., 2011, Virology; Lin et al., 2011, J. Virol.), Currently, his lab is interested in identifying the stem residues highly conserved among different flaviviruses and critical for DENV replication as potential targets for future antivirals.
Investigate the role of highly conserved residues in the stem region of the E protein on the entry and assembly of DENV serotype 4 (DENV4).
Investigate the mechanisms of impairment in entry and assembly of DENV4 E mutants.
Investigate the role of highly conserved residues in the stem on the entry and assembly of other DENV serotypes and other flaviviruses, including WNV and JEV.
Use of urea wash ELISA to distinguish Zika and dengue virus infections.
Emerging Infectious Diseases 2018In-depth analysis of the antibody response of individuals exposed to primary dengue virus infection.
PLoS Neglected Tropical Diseases 2011Preparation and anti-HIV activities of retrojusticidin B analogs and azalignans.
Bioorganic Medicinal Chemistry 2004Detection of SARS-associated coronavirus in throat wash and saliva in early diagnosis.
Emerging Infectious Diseases 2004Concurrent infections by two dengue virus serotypes among dengue patients in Taiwan.
Journal of Microbiology and Immunology and Infection 2003Rapid detection of human immunodeficiency virus type 1 subtype e infection by PCR.
Journal of Clinical Microbiology 2002Dengue type 3 virus in plasma is a population of closely related genomes: quasispecies.
Journal of Virology 2002Sequence diversity of the capsid gene and the nonstructural gene NS2B of dengue-3 virus in vivo.
Virology 2002
Diane W. Taylor, Ph.D.
Professor
Department of Tropical Medicine, Medical Microbiology and Pharmacology
John A. Burns School of Medicine
Phone: 808-692-1608
Office: BSB 320J
Email: dwtaylor@hawaii.edu
| 1968 | B.A. | University of Hawaiʻi at Mānoa, Honolulu, HI |
| 1970 | M.S. | (Microbiology) University of Hawaiʻi at Mānoa, Honolulu, HI |
| 1975 | Ph.D. | (Zoology) University of Hawaiʻi at Mānoa, Honolulu, HI |
| 1978 | Post-Doctoral Fellow | (Tropical Medicine) University of Hawaiʻi at Mānoa, Honolulu, HI |
| 1982 | Staff Fellow | (Immunology) Laboratory of Microbial Immunity, NIAID, NIH, Bethesda, MD |
| 1982-1986 | Assistant Professor, Department of Biology, Georgetown University, Washington, DC |
| 1986-1993 | Associate Professor, Department of Biology, Georgetown University, Washington, DC |
| 1993-2010 | Professor, Department of Biology, Georgetown University, Washington, DC |
| 2005-present | Professor, Department of Tropical Medicine, Medical Microbiology and Pharmacology, University of Hawaiʻi at Mānoa, Honolulu, HI |
| 1986-1997 | Editorial Board, American Journal of Tropical Medicine and Hygiene |
| 1986-1997 | Reviewer, Infection and Immunity |
| 1988-1991 | Consultant for Beckton Dickinson |
| 1989-1990 | Consultant for Abbott Laboratories |
| 1991 | US patent Serial No. 939,113 |
| 1993-1997 | Member, Tropical Medicine and Parasitology Study Section, NIAID, NIH |
| 1997-1999 | Consultant for Abbott Laboratories |
| 2000 | Dean’s Award for Excellence in Teaching, Georgetown University |
| 2000 | US representative of the African Immunological Societies |
| 2001 | Georgetown University Career Research Achievement Award |
Research Keywords: Malaria, pregnancy, Cameroon
PCR-based detection of Plasmodium falciparum in saliva using mitochondrial cox3 and varATS primers.
Tropical Medicine and Health 2018A versatile, high through-put, bead-based phagocytosis assay for Plasmodium falciparum.
Scientific Reports 2017Timing of the human prenatal antibody response to Plasmodium falciparum antigens.
PLoS One 2017Prevalence of malaria, typhoid, toxoplasmosis and rubella among febrile children in Cameroon.
BMC Infectious Diseases 2016High avidity antibodies to full-length VAR2CSA correlate with absence of placental malaria.
PLoS One 2012Shift in epitope dominance of IgM and IgG responses to Plasmodium falciparum MSP1 block 4.
Malaria Journal 2010Dysregulation of angiopoietins is associated with placental malaria and low birth weight.
PLoS One 2010Influence of human chorionic gonadotropin (hCG) on in vitro growth of Plasmodium falciparum.
Malaria Journal 2009
Duane J. Gubler, Sc.D.Professor
Department of Tropical Medicine, Medical Microbiology and Pharmacology
John A. Burns School of Medicine
Email: dgubler@hawaii.edu
| 1963 | B.Sc. | (Entomology, Zoology) Utah State University, Logan, Utah |
| 1965 | M.Sc. | (Parasitology) University of Hawaiʻi at Mānoa, Honolulu, Hawaiʻi |
| 1969 | Sc.D. | (Pathobiology/Tropical Disease Ecology) Johns Hopkins University, School of Hygiene and Public Health, Baltimore, Maryland |
| 1969 | Instructor, Diagnostic Parasitology, Johns Hopkins University, Baltimore, Maryland |
| 1969-1971 | Principal Investigator, Medical Entomology Program, Johns Hopkins University Center for Medical Research and Training, Calcutta, India |
| 1969-1970 | Lecturer, Department of Pathobiology, School of Hygiene and Public Health, Johns Hopkins University, CMRT, Calcutta, India |
| 1970-1971 | Assistant Professor, Department of Pathobiology, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, Maryland |
| 1971-1974 | Assistant Professor of Tropical Medicine, University of Hawaiʻi School of Medicine, Honolulu, Hawaiʻi |
| 1974-1978 | Associate Professor of Tropical Medicine, University of Hawaiʻi School of Medicine (1976-78 LWOP) |
| 1971-1975 | Guest Researcher, Pacific Research Section, National Institute of Allergy and Infectious Diseases, Honolulu, Hawaiʻi |
| 1975-1978 | Head, Virology Department, U.S. Naval Medical Research Unit No. 2, Jakarta Detachment, Jakarta, Indonesia |
| 1978-1979 | Associate Professor, Department of Entomology, University of Illinois, Urbana, Illinois |
| 1980-1981 | Research Microbiologist, Division of Vector-Borne Viral Diseases, Center for Infectious Diseases (NCID), Centers for Disease Control and Prevention (CDC), Fort Collins, Colorado |
| 1981-1989 | Director, San Juan Laboratories, and Chief, Dengue Branch, Division of Vector-Borne Viral Diseases, NCID, CDC, San Juan, Puerto Rico |
| 1982-1989 | Professor Ad Honorum, Department of Biology, University of Puerto Rico, Rio Piedras, Puerto Rico |
| 1982-1989 | Professor Ad Honorum, Department of Microbiology, University of Puerto Rico, School of Medicine, San Juan, Puerto Rico |
| 1988-present | Adjunct Professor, Departments of International Health and Infectious Diseases and Immunology, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland |
| 1989-present | Adjunct Professor, Department of Microbiology, Colorado State University, Fort Collins, Colorado |
| 1989-2004 | Director, Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado |
| 2004-present | Professor, Department of Tropical Medicine and Medical Microbiology, John A. Burns School of Medicine, University of Hawaiʻi at Mānoa, Honolulu, Hawaiʻi |
| 2007-present | Director, Program on Emerging Infectious Diseases, Duke-NUS Graduate Medical School, Singapore |
| 1988 | Honorary Doctorate of Science degree from Southern Utah State University |
| 1988 | Charles Franklin Craig Lecturer, American Society of Tropical Medicine and Hygiene |
| 1990 | Meritorious Service Award, Rotary Foundation of Rotary International, Evanston IL |
| 2000 | International Service Above Self Award, Rotary Foundation of Rotary International, Evanston IL |
| 1984 | U.S. Public Health Service Commendation Medal |
| 1988 | U.S. Public Health Service Outstanding Service Medal |
| 1991 | U.S. Public Health Service Meritorious Service Medals |
| 1994 | Medal in Recognition of International Leadership in the Control of Dengue/Dengue Hemorrhagic Fever, Taiwan, ROC |
| 1996 | Secretary’s Award for Distinguished Service (Plague Emergency Response Team) |
| 2000 | Secretary’s Award for Distinguished Service (The Malaysia and Singapore Nipah Virus Epidemic Investigation) |
| 2001 | Secretary’s Award for Distinguished Service (West Nile Virus Encephalitis Investigation) |
| 1997 | Outstanding Alumni Award for Science and Research, The Johns Hopkins University School of Hygiene and Public Health, Baltimore MD |
| 1999-2000 | President, American Society of Tropical Medicine and Hygiene |
| Fellow, Infectious Diseases Society of America | |
| Fellow, American Association for the Advance of Science |
Research Keywords: Dengue, flaviviruses, arboviruses, medical entomology, vector ecology, emerging infectious diseases
Emerging vector-borne flavivirus diseases: are vaccines the solution?
Expert Review of Vaccines 2011Consequences of the expanding global distribution of Aedes albopictus for dengue virus transmission.
PLoS Neglected Tropical Diseases 2010Update on dengue: epidemiology, virus evolution, antiviral drugs, and vaccine development.
Current Infectious Diseases Report 2010George S.N. Hui, Ph.D.
Director, Molecular and Cellular Immunology Core
Professor
Department of Tropical Medicine, Medical Microbiology and Pharmacology
John A. Burns School of Medicine
Phone: 808-692-1609
Office: BSB 320K
Email: ghui@hawaii.edu
| 1987 - 1991 | Assistant Research Professor, Department of Tropical Medicine, University of Hawaiʻi |
| 1991 - 1996 | Associate Research Professor, Department of Tropical Medicine, University of Hawaiʻi |
| 1995 - 1996 | NIH-TMRC Visiting Scientist, Research Institutes for Tropical Medicine, Philippines |
| 1996 - present | Research Professor (with tenure), Department of Tropical Medicine, University of Hawaiʻi |
| 1991 - 2000 | American Society of Tropical Medicine & Hygiene, member |
| 1994 - 1996 | American Society of Tropical Medicine & Hygiene, Scientific Program Committee |
| 1994 - 1996 | Chairperson, University of Hawaiʻi, System-wide Animal Care and Use Committee |
| 1998 | Ad hoc Consultant, Trop.Diseases Res. (TDR), WHO, Vaccine Discovery Research |
| 1997 - 1999 | University of Hawaiʻi Committee on Human Subjects (IRB) |
| 1999 | External grant review consultant for the Austrian Science Fund |
| 1999 - present | Consultant, Hawaiʻi Biotechnology Inc. |
| 2005 - present | Consultant, Neugenesis Inc. |
| 2008 | President. American Society for Microbiology, Hawaiʻi Branch |
| 2009-present | External consultant for AIBS, Military Malaria Vaccine Program |
| 1999 | NIAID/NIH, Tropical Medicine & Parasitology (TMP) Special Study Section for RFA |
| 1997, 2000, 02-03 | NIAID/NIH, Vaccine Study Section (VAC 01, VAC 04, VAC 10) |
| 2003 | NIAID/NIH, SEP, Member of parent panel, and Sub-committee Chair, Regional Centers of Excellence for Biodefense and Emerging Infectious Diseases (RCE) |
| 2004 | NIAID, SEP, Operation of a Facility for Testing of Malaria Vaccines in Adult Human Subjects |
| 2006 | CSR/NIH, ZRG1 IMM-K (13) B, Influenza Vaccine Development |
| 2006 | NIAID/NIH, ZAI1-MH-M-C2. Malaria Vaccine Production and Support Services |
| 2004 - 2009 | CSR/NIH, Vaccines for Microbial Diseases (VMD) |
| 2010 | NIAID/NIH, ZAI1 AWA-M, M2. SEP. International Center of Excellence for Malaria Research |
| CSR/NIH, ZRG1 IMM-G 12B Small Business Grant Microbial Vaccine Development | |
| 2010 - 2011 | CSR/NIH, ZRG1 ZRG1 IMM-F07-C(20)L B cell Regulation & Tolerance to Cancer Antigens |
| 2011 | CSR/NIH, Bioengineering & Biosciences IRG, Biomaterials and Biointerfaces |
| CSR/NIH, ZRG1 IMM-K(02)M, Immunology |
Research Keywords: Malaria, vaccine, adjuvant
My research is on the development of blood stage malaria vaccines; and studies on the use of different vaccine adjuvants for the malaria vaccines. Specifically, we focus on the design of vaccines based on the Merozoite Surface Protein 1 (MSP1) by defining critical T and B epitopes of the molecule. We also evaluate the use of a variety of immunological adjuvants to enhance vaccine potency and at the same time define the critical pathway for adjuvants’ mode of action. Our approaches also study the use of nanoparticle platforms for antigen delivery.
Beside research, I am also the director of a biomedical sciences research training program for high school and college bound students called the STEP-UP Program (http://stepup.niddk.nih.gov) that is supported by NIDDK/NIH. The project recruits minority and disadvantage students from the Pacific Regions, Alaska and Puerto Rico into university/college research laboratories to engage in health related research under the mentorships of university faculty.
Training the next generation of minority health scientists: a STEP-UP in the right direction.
Hawaii Medical Journal 2011Vivek R. Nerurkar, Ph.D.
Director, Biocontainment Core
Professor and Chair
Department of Tropical Medicine, Medical Microbiology and Pharmacology
John A. Burns School of Medicine
Phone: 808-692-1668
Office: BSB 320G
Email: nerurkar@hawaii.edu
External Homepage
| 1980 | B.Sc. Biology, Chemistry, Physics; First Class | University of Bombay, Bombay, India |
| 1981 | D.M.L.T. Diploma in Medical Laboratory Technology | University of Bombay, Bombay, India |
| 1983 | M.Sc. Zoology (Animal Physiology); First Class | University of Bombay, Bombay, India |
| 1987 | Ph.D. Applied Biology (Cell and Molecular Biology) | Comparative Oncology Unit, Cancer Research Institute, University of Bombay, Bombay, India |
| 1981 | Technical Assistant, Department of Pathology and Clinical Biochemistry, Lokmanaya Tilak Medical College and Hospital, Bombay, India |
| 1981 - 1983 | Technical Assistant, Indian Red Cross, Bombay, India |
| 1987 | Research Associate, Department of Cell and Developmental Pathology, Cancer Research Institute, Bombay, India |
| 1987 - 1989 | Research Associate, Cancer Center, University of Rochester, Rochester, New York |
| 1989 | Postdoctoral Fellow, Department of Biological Sciences, State University of New York at Buffalo, Buffalo, New York |
| 1989 - 1992 | Visiting Fellow, Fogarty International Center (FIC), Laboratory of Central Nervous System Studies (LCNSS), National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH), Bethesda, Maryland |
| 1992 - 1993 | Visiting Associate, FIC, LCNSS, NINDS, NIH, Bethesda, Maryland |
| 1993 - 1994 | Guest Researcher, FIC, LCNSS, NINDS, NIH, Bethesda, Maryland |
| 1994 - 1996 | Assistant Researcher (Virology), Retrovirology Research Laboratory (RRL), Pacific Biomedical Research Center (PBRC), University of Hawaiʻi at Mānoa (UHM), Honolulu, Hawaiʻi |
| 1995 | Acting Director, RRL, PBRC, UHM, Honolulu, Hawaiʻi |
| 1996 - 2000 | Associate Professor, Interdisciplinary Biomedical Sciences Graduate Program, UHM, Honolulu, Hawaiʻi |
| 1996 - 2003 | Associate Researcher (Virology), RRL, PBRC, UHM, Honolulu, Hawaiʻi |
| 1998 - 1999 | Associate Professor, Department of Epidemiology, School of Public Health, UHM, Honolulu, Hawaiʻi |
| 1999 - 2003 | Associate Professor, Department of Public Health Sciences and Epidemiology, John A. Burns School of Medicine (JABSOM), UHM, Honolulu, Hawaiʻi |
| 2000 - 2003 | Associate Professor, Cell and Molecular Biology (CMB) Graduate Program, and Tropical Medicine and Medical Microbiology (TMMM) Graduate Program, JABSOM, UHM, Honolulu, Hawaiʻi |
| 2001 - 2003 | Associate Professor, Microbiology Department Graduate Program, College of Natural Sciences, UHM, Honolulu, Hawaiʻi |
| 2001 - 2006 | Activity Leader, Pathobiology of HIV-Associated Disorders, NIH-NCRR Research Centers in Minority Institutions (RCMI) Program, JABSOM, UHM, Honolulu, Hawaiʻi |
| 2002 - 2003 | Associate Professor, Molecular Biosciences and Biosystems Engineering (MBBE) Graduate Program, College of Tropical Agriculture and Human Resources UHM, Honolulu, Hawaiʻi |
| 2002 - 2004 (Sept) | Member, PBRC Executive Committee, PBRC, UHM, Honolulu, Hawaiʻi |
| 2002 - Present | Director, RRL, PBRC/JABSOM, UHM, Honolulu, Hawaiʻi |
| 2003 (July) | Researcher (Virology), RRL, PBRC, UHM, Honolulu, Hawaiʻi |
| 2003 (Sept) - Present | Professor, Department of Tropical Medicine and Medical Microbiology, JABSOM, UHM, Honolulu, Hawaiʻi |
| 2003 - Present | Professor, Microbiology, CMB, MBBE, TMMM, and Epidemiology Graduate Programs, UHM, Honolulu, Hawaiʻi |
| Director Technical Core, Pacific Center for Emerging Infectious Diseases Research, Center of Biomedical Research Excellence NIH-NCRR, JABSOM, UHM, Honolulu, Hawaiʻi | |
| 2005 (July) - Present | Professor (Tenured), Department of Tropical Medicine, Medical Microbiology and Pharmacology, JABSOM, UHM, Honolulu, Hawaiʻi |
| 2006 - 2008 | Associate Activity Leader, Tropical Infectious Diseases Detection and Prevention Core (TDDPC) activity, NIH-NCRR RCMI, JABSOM, UHM, Honolulu, Hawaiʻi |
| 2008 (Aug) - Present | Activity Leader, TDDPC activity, NIH-NCRR RCMI Program, JABSOM, UHM, Honolulu, Hawaiʻi |
| 2008 (Nov) - Present | Interim Chair, Department of Tropical Medicine, Medical Microbiology and Pharmacology, JABSOM, UHM, Honolulu, Hawaiʻi |
| 2009 - 2010 | President-Elect, Amercian Society for Microbiology Hawaii Chapter, Honolulu, Hawaiʻi |
| 2009 (Feb) - Present | Director, Biocontainment Facility, JABSOM, UHM, Honolulu, Hawaiʻi |
| 2010 (Jan) - Present | Chair, Department of Tropical Medicine, Medical Microbiology and Pharmacology, JABSOM, UHM, Honolulu, Hawaiʻi |
| 2010 (April) - Present | President, Amercian Society for Microbiology Hawaii Chapter, Honolulu, Hawaiʻi |
Research Keywords: Molecular virology, arbovirology, viral diagnostics
Dr. Vivek R. Nerurkar, who joined the University of Hawaiʻi at Mānoa (UHM) in 1994, to develop the Research Centers in Minority Institutions (RCMI), NCRR-supported Retrovirology Activity following a five-year appointment as a Visiting Fellow and Visiting Associate of the NINDS, NIH, has mentored over 100 undergraduate and graduate students, technicians and postdoctoral fellows in laboratory-based research during the past 25 years. Dr. Nerurkar’s major area of research interest is in infectious diseases, specifically to study the pathogenesis of orphan diseases and orphan microbial agents. Over the past two decades he has conducted research in the diverse but related areas of virology, specifically neurovirology.
Dr. Nerurkar conducts research on pathogenesis of West Nile virus-associated meningoencephalitis and pathogenesis of the fatal demyelinating disease, progressive multifocal leukoencephalopathy (PML). A talented virologist, Dr. Nerurkar, has extensive experience in classical and molecular microbiological techniques, as documented in publications appearing in peer-reviewed journals and in successful grant applications from local and national agencies. He has utilized molecular methods to study a wide range of emerging and re-emerging microbial pathogens. Dr. Nerurkar has collaborated nationally and internationally with investigators from various ethnic backgrounds. He has extensive experience of conducting research in international arena and his abilities to train minority students, enrolled at the UHM (a minority institution) and international students and postdoctoral fellows, is well documented in the form of collaborative publications. He is member of the graduate faculty of the Department of Cell and Molecular Biology (CMB), JABSOM; Department of Molecular Biosciences and Biosystems Engineering (MBBE), College of Tropical Agriculture and Human Resources (CTAHR); and Department of Microbiology, College of Natural Sciences (CNS), UHM. He is part of the NIH Short Term Education Program for Underrepresented Persons (STEP UP) Summer program, which trains high school and undergraduate students in laboratory research. He is also a mentor of the NIMH, NIH R25 grant, which trains minorities and other disadvantaged students and faculty in conducting research on mental health related issues. Dr. Nerurkar will serve as a Core Director and Mentor on this proposal.
PCR-based detection of Plasmodium falciparum in saliva using mitochondrial cox3 and varATS primers.
Tropical Medicine and Health 2018Recombinant Zika virus subunits are immunogenic and efficacious in mice.
mSphere 2018Prevalence of malaria, typhoid, toxoplasmosis and rubella among febrile children in Cameroon.
BMC Infectious Diseases 2016Clinical and imaging findings in an infant with Zika embryopathy.
Clinical Infectious Diseases 2016Functional analysis of West Nile virus proteins in human cells.
Methods in Molecular Biology 2016In vitro and in vivo blood-brain barrier models to study West Nile virus pathogenesis.
Methods in Molecular Biology 2016Evidence for a “founder effect” among HIV-infected injection drug users (IDUs) in Pakistan.
BMC Infectious Diseases 2010In vitro effects of selenium deficiency on West Nile virus replication and cytopathogenicity.
Virology Journal 2008
Amanda Pires, B.S.
Research Assistant
| 2008 | B.S. | (Biology) Creighton University, Omaha, Nebraska |
Kelsey Roe, M.S., Ph.D.Research Assistant
Department of Tropical Medicine, Medical Microbiology and Pharmacology
John A. Burns School of Medicine
Phone: (808) 692-1620
Email: kelsey20@hawaii.edu
| 2009 | B.S. | (Biochemistry) Western Washington University, Bellingham,WA |
| 2012 | M.S. | (Tropical Medicine) University of Hawaiʻi at Mānoa, Honolulu, HI |
| 2015 | Ph.D. | (Tropical Medicine) University of Hawaiʻi at Mānoa, Honolulu, HI |
Triggering receptor expressed on myeloid cells-1 (TREM-1): a new player in antiviral immunity?
Frontiers in Microbiology 2014
Martin Chang, B.S.
Research Assistant
Department of Tropical Medicine, Medical Microbiology and Pharmacology
John A. Burns School of Medicine
Email: changmar@hawaii.edu
Yi-Chieh Wu, M.S.Research Assistant
Department of Tropical Medicine, Medical Microbiology and Pharmacology
John A. Burns School of Medicine
Email: wuyc@hawaii.edu
| 2006 | B.S. | Department of Medical Biotechnology and Laboratory Science, Chang Gung University, Taiwan |
| 2010 | M.S. | (Microbiology) College of Medicine, National Taiwan University, Taipei, Taiwan |
Department of Bioengineering
Department of Plant and Microbial Biology
University of California Berkeley Berkeley, CA
| 1993 | B.A. | (Computer Science) University of California Santa Cruz |
| 1997 | Ph.D. | (Computer Science) University of California Santa Cruz |
| 1997-1999 | Chief Scientist, Molecular Applications Group, Palo Alto, CA (Developed the Panther phylogenomic tools, acquired by Celera Genomics) |
| 1999-2001 | Principal Scientist, Protein Informatics, Celera Genomics, CA (Panther classification of the human genome) |
| 2001-2006 | Assistant Professor, Department of Bioengineering, University of California, Berkeley, CA |
| 2006-Present | Associate Professor, Department of Bioengineering and Department of Plant and Microbial Biology, University of California, Berkeley, CA |
| 1993 | Elected to Phi Beta Kappa |
| 1993 | National Science Foundation Three-Year Graduate Research Fellowship |
| 1996 | Program in Mathematics and Molecular Biology Fellowship |
| 2003 | National Science Foundation CAREER Award |
| 2004 | National Science Foundation Presidential Early Career Award in Science and Engineering (PECASE) |