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News & Research Highlights
18 August 2017: Northern/Pacific Global Health Research Fellows Training Consortium
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The University of Hawaii at Manoa, under the leadership of Vivek R. Nerurkar, Ph.D., professor and chair of the Department of Tropical Medicine, Medical Microbiology and Pharmacology, of the John A. Burns School of Medicine, has successfully competed for renewed five-year funding for the Northern/Pa…


10 August 2017: Understanding Zika Virus Infection: The Development of an Animal Model

Zika virus is an emerging mosquito-borne pathogen, which has caused great concern to the international community. Eighty percent of individuals infected with Zika virus present no symptoms, however infection has been linked to development of severe fetal abnormalities including stillbirth and microc…


27 July 2017: Awardees of the 2017 COBRE Small Grants Program
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Funding has been awarded to four highly meritorious proposals, submitted in response to the COBRE Small Grants Program funding opportunity announcement (FOA).

Mukesh Kumar, Ph.D.
In utero Pathogenesis of African and Asian Zika Virus Strains in Guinea Pig

Axel T. Lehrer, Ph.D.
Innate …


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Recent Publications
Frontiers in Microbiology, 2017, Ebola virus glycoprotein induces an innate immune response in vivo via TLR4.
Lai C-Y, Strange DP, Wong TAS, Lehrer AT, Verma S.

Ebola virus (EBOV), a member of the Filoviridae family, causes the most severe form of viral hemorrhagic fever. Although no FDA licensed vaccine or treatment against Ebola virus disease (EVD) is currently available, Ebola virus glycoprotein (GP) is the major antigen used in all candidate Ebola vacci…


Vaccine, 2017, Recombinant proteins of Zaire ebolavirus induce potent humoral and cellular immune responses and protect against live virus infection in mice.
Lehrer AT, Wong TS, Lieberman MM, Humphreys T, Clements DE, Bakken RR, Hart MK, Pratt WD, Dye JM.

Infections with filoviruses in humans are highly virulent, causing hemorrhagic fevers which result in up to 90% mortality. In addition to natural infections, the ability to use these viruses as bioterrorist weapons is of significant concern. Currently, there are no licensed vaccines or therapeutics …


Immunobiology, 2017, Schlafen 14 (SLFN14) is a novel antiviral factor involved in the control of viral replication.
Seong RK, Seo SW, Kim JA, Fletcher SJ, Morgan NV, Kumar M, Choi YK, Shin OS.

Schlafen (SLFN) proteins have been suggested to play important functions in cell proliferation and immune cell development. In this study, we determined the antiviral activities of putative RNA-helicase domain-containing SLFN14. Murine SLFN14 expression was specifically induced by TLR3-mediated path…


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Seminars & Events
26 September 2017, 10:15 AM
Abhay R Satoskar, M.B.B.S., M.D., Ph.D.
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Drugs for Neglected Tropical Diseases: Current Challenges and Future Opportunities


14 September 2017, 5:30 pm
Richard Yanagihara, M.D.
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Hantaviruses: A Personal Journey of Discovery and New Beginnings


02 June 2017, 12:00 PM - 1:00 PM
Yi Pan, Ph.D.
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Deep Learning for Bioinformatics Applications


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Workshops
21 October 2016, 10:00 AM
Alexandra Gurary, Ph.D.

Attune Nxt Training


20 October 2016, 03:30 PM
Alexandra Gurary, Ph.D.

Luminex Acquisition Software Training


20 October 2016, 10:00 AM
Alexandra Gurary, Ph.D.

Attune Nxt Training


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Recent Grants
NIH/OD, R21OD024896 A Guinea Pig Model of Zika Virus Disease
09/01/2017 - 08/31/2019
NIH/FIC, 2D43TW009345-06 Northern/Pacific Universities Global Health Research Training Consortium
07/01/2017 - 06/30/2022
NIH/NIAID, R01AI132323 Preclinical Development of a Thermostable Trivalent Filovirus Vaccine
06/20/2017 - 05/31/2022
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