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News & Research Highlights
07 December 2018: Efficacy of A Recombinant Subunit Protein-Based Zika Virus Vaccine in Non-human Primates
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Dr. Alex Lehrer, a former COBRE Small Grants Program awardee, and his research team have successfully developed a recombinant subunit protein-based vaccine for Zika virus. Previously, he demonstrated that this vaccine was effective in protecting mice from Zika virus challenge. These studies have now…


09 November 2018: Stopping the Sting
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The 20-year pursuit of developing effective treatment regimens for box jellyfish envenomation by Angel Yanagihara, a Fulbright Specialist and former COBRE Small Grants Program awardee, is featured in the November 9, 2018 issue of Science.
https://www.sciencemag.org/news/2018/11/jellyfish-almost-kil...


08 October 2018: Efficacy of A Recombinant Subunit Protein-Based Zika Virus Vaccine

Zika Virus (ZIKV), a virus with no severe clinical symptoms or sequelae previously associated with human infection, became a public health threat following an epidemic in French Polynesia in 2013-2014 that resulted in neurological complications associated with infection. Although no treatment curren…


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Recent Publications
Frontiers in Immunology, 2018, A recombinant subunit based Zika virus vaccine is efficacious in non-human primates.
Medina LO, To A, Lieberman MM, Wong TAS, Namekar M, Nakano E, Andersen H, Yalley-Ogunro J, Greenhouse J, Higgs S, Huang YS, Vanlandingham DL, Horton JS, Clements DE, Lehrer AT.

Zika Virus (ZIKV), a virus with no severe clinical symptoms or sequelae previously associated with human infection, became a public health threat following an epidemic in French Polynesia 2013-2014 that resulted in neurological complications associated with infection. Although no treatment currently…


Scientific Reports, 2018, Immunoprofiles of human Sertoli cells infected with Zika virus reveals unique insights into host-pathogen crosstalk.
Strange DP, Green R, Siemann DN, Gale M Jr, Verma S.

Confirmed reports of Zika virus (ZIKV) in seminal fluid months after clearance of viremia suggests that ZIKV can establish persistent infection in the seminiferous tubules, an immune privileged site of the testis. The seminiferous tubule epithelium is mainly composed of Sertoli cells that function t…


Emerging Infectious Diseases, 2018, Use of urea wash ELISA to distinguish Zika and dengue virus infections.
Tsai WY, Youn HH, Tyson J, Brites C, Tsai JJ, Pedroso C, Drexler JF, Balmaseda A, Harris E, Wang WK.

Serologic testing remains crucial for Zika virus diagnosis. We found that urea wash in a Zika virus nonstructural protein 1 IgG ELISA distinguishes secondary dengue virus infection from Zika virus infection with previous dengue (sensitivity 87.5%, specificity 93.8%). This test will aid serodiagnosis…


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Seminars & Events
24 October 2018, 12:00 PM
Kevin Palmer, Ph.D.
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How Sri Lanka Eliminated Malaria


23 October 2018, 10:00 AM
Lisa Bellemare

Flow Cytometry Applications Seminar: From Immunophenotyping and Beyond


17 October 2018, 12:00 PM
Dr. Gultekin Tamguney
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Peripheral Challenge with Alpha-Synuclein Fibrils Results in Parkinson’s Disease-like Signs in Mice


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Workshops
17 October 2018, 11:00 AM
Bela Desai, Ph.D.

Improving Protein Detection: Accurate, High-Sensitivity and High-Throughput Analysis of Biomarkers


21 September 2018, 10:00 AM
Basile Siewe, Ph.D.

Leverage The Power of Flow Cytometry


30 January 2018, 10:00 AM
Bela Desai, Ph.D.

Principles of Luminex multiplexing technology: The why, how, when, & where of detecting multiple analytes from the same well


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Recent Grants
NIH/FIC, 1D71TW010434-01A1 Sustainable Research Training and Capacity Building in Liberia for Emerging Viral Epidemics
09/08/2017 - 08/31/2019
NIH/OD, R21OD024896 A Guinea Pig Model of Zika Virus Disease
09/01/2017 - 08/31/2019
NIH/FIC, 2D43TW009345-06 Northern/Pacific Universities Global Health Research Training Consortium
07/01/2017 - 06/30/2022
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