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News & Research Highlights
27 July 2017: Awardees of the 2017 COBRE Small Grants Program
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Funding has been awarded to four highly meritorious proposals, submitted in response to the COBRE Small Grants Program funding opportunity announcement (FOA).

Mukesh Kumar, Ph.D.
In utero Pathogenesis of African and Asian Zika Virus Strains in Guinea Pig

Axel T. Lehrer, Ph.D.
Innate …


10 April 2017: A Guinea Pig Model of Zika Virus Infection
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Animal models are critical to understand the transmission and pathogenesis of infectious diseases and to develop countermeasures for their prevention and spread. Here, we report that immunocompetent Dunkin Hartley guinea pigs are susceptible to infection by a contemporary American strain of Zika vir…


30 March 2017: COBRE Small Grants Program

The purpose of the Centers of Biomedical Research Excellence (COBRE) Small Grants Program is to provide support via three funding mechanisms to University of Hawaii (UH) faculty engaged in research in tropical medicine, medical microbiology, immunology, and/or emerging infectious diseases. However, …


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Recent Publications
Vaccine, 2017, Recombinant proteins of Zaire ebolavirus induce potent humoral and cellular immune responses and protect against live virus infection in mice.
Lehrer AT, Wong TS, Lieberman MM, Humphreys T, Clements DE, Bakken RR, Hart MK, Pratt WD, Dye JM.

Infections with filoviruses in humans are highly virulent, causing hemorrhagic fevers which result in up to 90% mortality. In addition to natural infections, the ability to use these viruses as bioterrorist weapons is of significant concern. Currently, there are no licensed vaccines or therapeutics …


Immunobiology, 2017, Schlafen 14 (SLFN14) is a novel antiviral factor involved in the control of viral replication.
Seong RK, Seo SW, Kim JA, Fletcher SJ, Morgan NV, Kumar M, Choi YK, Shin OS.

Schlafen (SLFN) proteins have been suggested to play important functions in cell proliferation and immune cell development. In this study, we determined the antiviral activities of putative RNA-helicase domain-containing SLFN14. Murine SLFN14 expression was specifically induced by TLR3-mediated path…


Toxins (Basel), 2017, Evaluation of Cyanea capillata sting management protocols using ex vivo and in vitro envenomation models.
Doyle TK, Headlam JL, Wilcox CL, MacLoughlin E, Yanagihara AA.

Lion’s mane jellyfish (Cyanea capillata) stings cause severe pain and can lead to dangerous systemic effects, including Irukandji-like syndrome. As is the case for most cnidarian stings, recommended medical protocols in response to such stings lack rigorous scientific support. In this study, we soug…


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Seminars & Events
02 June 2017, 12:00 PM - 1:00 PM
Yi Pan, Ph.D.
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Deep Learning for Bioinformatics Applications


15 May 2017, 12:00 PM - 1:00 PM
Rose Gana Fomban Leke, Ph.D.
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A Personal Journey in Global Health: Eradication of Polio and Malaria


20 April 2017, 2:00 PM - 4:00 PM
David A. Relman, M.D., Victoria Fan, Sc.D., Vivek R. Nerurkar, Ph.D., Richard J. Kuhn, Ph.D.
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2017 COBRE Mini-symposium


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Workshops
21 October 2016, 10:00 AM
Alexandra Gurary, Ph.D.

Attune Nxt Training


20 October 2016, 03:30 PM
Alexandra Gurary, Ph.D.

Luminex Acquisition Software Training


20 October 2016, 10:00 AM
Alexandra Gurary, Ph.D.

Attune Nxt Training


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Recent Grants
NIH/NIAID, R01AI132323 Preclinical Development of a Thermostable Trivalent Filovirus Vaccine
06/20/2017 - 05/31/2022
NIH/NIDDK, 2R25DK078386-11 Pacific High Schools STEP-UP to Biomedical Research
03/01/2017 - 02/28/2022
NIH/NIAID, R21AI129465 Under Attack: Modulation of the Blood-Testes Barrier by Zika Virus
11/08/2016 - 10/31/2018
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