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News & Research Highlights
29 July 2015: COBRE Small Grants Program

APPLICATION DUE DATE: August 21, 2015 at 4:00 p.m. (Hawaii time)
SCIENTIFIC REVIEW PERIOD: August to September 2015

University of Hawaii (UH) faculty engaged in research in microbiology, immunology, infectious diseases and tropical medicine a…

27 May 2015: Hantavirus in the Northern Red-backed Vole

Genetic evidence is provided for the first time that Hokkaido virus (HOKV) is harbored by both the grey red-backed vole (Myodes rufocanus) and northern red-backed vole (Myodes rutilus) in Siberian Russia. That HOKV was found irrespective of whether the dominant Myodes species was M. rutilus (Teletsk…

20 May 2015: Partnership with Hawaii Biotech Pursues Vaccine Against Ebola

The University of Hawaii John A. Burns School of Medicine is ready to move forward with human clinical trials for a vaccine to combat the deadly Ebola virus.

“Based on animal trials in mice, guinea pigs and monkeys, we have selected now a formulation we believe is worth testing in humans,” said A…

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Recent Publications
Journal of Neuroinflammation, 2015, Induction of virus-specific effector immune cell response limits virus replication and severe disease in mice infected with non-lethal West Nile virus Eg101 strain.
Kumar M, Roe K, O'Connell M, Nerurkar VR

Background: West Nile virus (WNV) is a neurotropic flavivirus that has emerged globally as a significant cause of viral encephalitis in humans. Herein, we investigated the immunological responses induced by two phylogenetically related WNV strains of lineage 1, WNV NY99, and WNV Eg101.
Methods: Eig…

Human Vaccines and Immunotherapeutics, 2015, Preclinical development of HIvax: Human survivin highly immunogenic vaccines.
Hoffmann PR, Panigada M, Soprana E, Terry F, Bandar IS, Napolitano A, Rose AH, Hoffmann FW, Ndhlovu LC, Belcaid M, Moise L, De Groot AS, Carbone M, Gaudino G, Matsui T, Siccardi A, Bertino P.

Our previous work involved the development of a recombinant fowlpox virus encoding survivin (FP-surv) vaccine that was evaluated for efficacy in mesothelioma mouse models. Results showed that FP-surv vaccination generated significant immune responses, which led to delayed tumor growth and improved a…

BMC Bioinformatics, 2015, An evaluation of statistical methods for DNA methylation microarray data analysis.
Li D, Xie Z, Pape ML, Dye T.

For DNA methylation studies with small sample size, the bump hunting method and the empirical Bayes method are recommended when DNA methylation levels across CpG loci are independent, while only the bump hunting method is recommended when DNA methylation levels are correlated across CpG loci. All me…

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Seminars & Events
14 August 2015, 12:15 PM
James Kelley, M.P.H., Ph.D.

Frequency and Characterization of CD14+ Monocytes and Macrophage Subsets in Children with Dengue Fever in Bangkok, Thailand

22 May 2015, 12:00 PM - 1:00 PM
Tung T. Hoang, Ph.D.

The ‘Transitome’ of Burkholderia pseudomallei Reveals Novel Mechanisms and Regulation of Virulence

07 May 2015, 10:30 AM
Rebecca LaFond, Ph.D.

Preperation of High Quality Single Cells Suspensions: How to Improve Your Signal and Get Your Analysis Faster Strategies for Unwanted Cell Populations or Dead Cells

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22 June 2015, 9:00 AM - 5:00 PM (Monday and Tuesday)

Software Carpentry Workshop

03 February 2015, 9:30 AM
Bela Desai, Ph.D.

Principles of Flow Cytometry and Applications

15 March 2013, 1:00 PM - 3:30 PM
Robert Bowers, Ph. D.

Using QIIME for Microbial Community Analysis

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Recent Grants
NIH/NIAID, R01AI119185 Defining a Protective Ebola Vaccine in Non-human Primates
08/28/2015 - 07/31/2019
Hawaii Community Foundation, 15ADVC-75878 West Nile Virus NS2B-NS3 Heterodimer as a Potential Target for Antiviral Drug Development
07/15/2015 - 01/14/2017
Department of Defense, U.S. Army Medical Research Acquisitions Administration, W81XWH-15-R-0015 US Army Medical Research Institute of Infectious Diseases (USAMRIID) Requirement to Develop, Produce and Deploy MAGPIX-Based Immunoassays
07/13/2015 - 07/12/2016
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