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News & Research Highlights
29 July 2014: West Nile Virus Neuroinvasive Disease
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To identify the mechanisms by which West Nile virus (WNV) causes disruption of the blood-brain barrier (BBB) and leukocyte migration into the brain, the role of endothelial cell adhesion molecules (CAMs) was studied in an in vitro BBB model. Permeability of the BBB model increased following leukocyt…


02 July 2014: Cover Art - Viral Immunology
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A collaborative study between COBRE investigators and researchers at Korea University has been published as the cover story in the August 2014 issue of Viral Immunology. The cover art shows the immunohistochemical detection of host glial fibrillary acidic protein and viral N protein in the brains of…


04 June 2014: Cover Art - Journal of Virology
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The discovery of hantavirus RNA in archival tissues from the Geata mouse shrew (Myosorex geata) and Kilimanjaro mouse shrew (Myosorex zinki) captured in Tanzania has been selected for the cover of the July 2014 issue of the Journal of Virology. As in earlier reports of previously unrecognized shrew-…


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Recent Publications
PLoS One, 2014, Blocking phosphatidylcholine utilization in Pseudomonas aeruginosa, via mutagenesis of fatty acid, glycerol and choline degradation pathways, confirms the importance of this nutrient source in vivo.
Sun Z, Kang Y, Norris MH, Troyer RM, Son MS, Schweizer HP, Dow SW, Hoang TT.

Pseudomonas aeruginosa can grow to very high-cell-density (HCD) during infection of the cystic fibrosis (CF) lung. Phosphatidylcholine (PC), the major component of lung surfactant, has been hypothesized to support HCD growth of P. aeruginosa in vivo. The phosphorylcholine headgroup, a glycerol molec…


Viruses, 2014, Infection with non-lethal West Nile virus Eg101 strain induces immunity that protects mice against the lethal West Nile virus NY99 strain.
Kumar M, O'Connell M, Namekar M, Nerurkar VR.

Herein we demonstrate that infection of mice with West Nile virus (WNV) Eg101 provides protective immunity against lethal challenge with WNV NY99. Our data demonstrated that WNV Eg101 is largely non-virulent in adult mice when compared to WNV NY99. By day 6 after infection, WNV-specific IgM and IgG …


PLoS One, 2014, West Nile virus-induced cell adhesion molecules on human brain microvascular endothelial cells regulate leukocyte adhesion and modulate permeability of the in vitro blood-brain barrier model.
Roe K, Orillo B, Verma S.

Characterizing the mechanisms by which West Nile virus (WNV) causes blood-brain barrier (BBB) disruption, leukocyte infiltration into the brain and neuroinflammation is important to understand the pathogenesis of WNV encephalitis. Here, we examined the role of endothelial cell adhesion molecules (CA…


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Seminars & Events
17 September 2014, 12:00 PM - 1:30 PM
(1) Axel T. Lehrer, PhD, Asst Professor, Dept of Tropical Medicine, JABSOM; (2) John M. Berestecky, PhD, Professor of Microbiology, Kapiolani Community College; (3) Erlaine F. Bello, MD, Associate Professor, Dept of Medicine, JABSOM

RESEARCH COLLOQUIUM: “Ebola - What Do We Know?”


08 August 2014, 3:45 PM - 4:45 PM
Jonathan Mermin, MD, MPH
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CANCELLED DUE TO HURRICANE ISELLE HIV, Viral Hepatitis, STD, andTB Prevention Today: What are the Big Unanswered Questions?


05 June 2014, 11:00 AM - 12:00 PM
David M. Morens, M.D.
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A History of Contagion


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Workshops
15 March 2013, 1:00 PM - 3:30 PM
Robert Bowers, Ph. D.

Using QIIME for Microbial Community Analysis


13 November 2012, 9:00 AM - 5:00 PM
Pawel Michalak, Ph.D.

RNA-seq


08 November 2012, 1:00 PM
Mirja Wine, Ph.D.

Considerations for Monitoring Immune Cells by Flow Cytometry, Signal Transduction Pathways, Intracellular Proteins, and Tetramers


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Recent Grants
NIH/NIAID, R01AI110769 Mature Virus-like Particles as a New Strategy for Dengue Virus Vaccines
04/01/2014 - 03/31/2019
NIH/NIAID, R21AI105286 Defining Immunity to Placental Malaria using a Multi-assay Predictive Model
03/01/2014 - 02/28/2016
NIH/NIMHD, T37MD008636 International Biomedical Research Training for Hawaiian & Pacific Island Students
12/01/2013 - 11/30/2018
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