Ms. Kelsey Roe, a second-year Ph.D. student in Dr. Saguna Verma’s laboratory in the Department of Tropical Medicine, Medical Microbiology and Pharmacology, has received the Ellen M. Koenig Award in Medicine for work on West Nile virus (WNV) neuropathogenesis, published recently in the Journal of Gen…

The inflammasome adaptor protein, apoptosis-associated speck-like protein containing CARD (ASC), mediates a critical step in innate immune signaling by bridging the interaction between the NLRPs and caspase-1 in inflammasome complexes. In this study, we demonstrated that ASC is essential for the act…

Recent studies demonstrate genetically distinct hantaviruses in shrews, moles and bats. The immunological responses to these newfound hantaviruses in humans are unknown. We compared the innate immune responses to Imjin virus (MJNV) and Thottapalayam virus (TPMV), two shrew-borne hantaviruses, with t…

Malaria is a global infectious disease that threatens the lives of millions of people. Transcriptomics, proteomics and functional genomics studies, as well as sequencing of the Plasmodium falciparum and Homo sapiens genomes, have shed new light on this host-parasite relationship. Recent advances in …

This study explored the novel use of iron oxide (IO) nanoparticles (<20 nm) as a vaccine delivery platform without additional adjuvants. A recombinant malaria vaccine antigen, the merozoite surface protein 1 (rMSP1), was conjugated to IO nanoparticles (rMSP1-IO). Immunizations in outbred mice with r…

We have proposed McRUM, a multiclass extension of binary CRUM. McRUM with NaÃ?¯ve decoding algorithm is computationally efficient in run-time and its predictive performance is comparable to the well-known SVM, showing its potential in solving large-scale multiclass problems in bioinformatics and ot…