Publication Detail
Crystal structure of human enterovirus 71.
Plevka P, Perera R, Cardosa J, Kuhn RJ, Rossmann MG.
Citation
Plevka P, Perera R, Cardosa J, Kuhn RJ, Rossmann MG. (2012) Crystal structure of human enterovirus 71. Science 336(6086):1274.
Abstract
Enterovirus 71 is a picornavirus associated with fatal neurological illness in infants and young children. Here, we report the crystal structure of enterovirus 71 and show that, unlike in other enteroviruses, the “pocket factor,” a small molecule that stabilizes the virus, is partly exposed on the floor of the “canyon.” Thus, the structure of antiviral compounds may require a hydrophilic head group designed to interact with residues at the entrance of the pocket.
| Link: | http://www.ncbi.nlm.nih.gov/pubmed/22383808 |
| PMID: | 22383808 |
| PMCID: | PMC3448362 |