Design, synthesis, and biological evaluation of thiazoles targeting flavivirus envelope proteins.

Mayhoub AS, Khaliq M, Kuhn RJ, Cushman M.

Citation

Mayhoub AS, Khaliq M, Kuhn RJ, Cushman M. (2011) Design, synthesis, and biological evaluation of thiazoles targeting flavivirus envelope proteins. Journal of Medicinal Chemistry 54(6):1704-1714.

Abstract

A series of third-generation analogues of methyl 4-(dibromomethyl)-2-(4-chlorophenyl)thiazole-5-carboxylate (1), which had the most potent antiviral activity among the first- and second-generation compounds, have been synthesized and tested against yellow fever virus using a cell-based assay. The compounds were designed with the objectives of improving metabolic stability, therapeutic index, and antiviral potency. The biological effects of C4 and C5 substitution were examined. The methylthio ester and the dihydroxypropylamide analogues had the best antiviral potencies and improved therapeutic indices and metabolic stabilities relative to the parent compound 1.