Publication Detail
West Nile virus methyltransferase domain interacts with protein kinase G.
Keating JA, Bhattacharya D, Lim PY, Falk S, Weisblum B, Bernard KA, Sharma M, Kuhn RJ, Striker R.
Citation
Keating JA, Bhattacharya D, Lim PY, Falk S, Weisblum B, Bernard KA, Sharma M, Kuhn RJ, Striker R. (2013) West Nile virus methyltransferase domain interacts with protein kinase G. Virology Journal 10242.
Abstract
PKG is not required for WNV replication, but does make a stable interaction with NS5. While the consequence of the NS5:PKG interaction when it occurs is unclear, mutational data demonstrates that this interaction occurs in a region of NS5 that is otherwise necessary for replication. Overall, the results identify an interaction between virus and a cellular kinase and suggest a role for a host kinase in enhancing flaviviral replication.
| Link: | http://www.ncbi.nlm.nih.gov/pubmed/23876037 |
| PMID: | 23876037 |
| PMCID: | PMC3725163 |