New insights into inhibition of human immunodeficiency virus type 1 replication through mutant tRNALys3.
Wu C, Nerurkar VR, Lu Y.
Wu C, Nerurkar VR, Lu Y. (2013) New insights into inhibition of human immunodeficiency virus type 1 replication through mutant tRNALys3. Retrovirology 10(1):112.
These results highlight the importance of the length of complementarity between the 3’ terminus of the mutant tRNALys3 and its target site, and the feasibility of targeting multiple sites within the HIV-1 genome through mutant tRNALys3. Intervention of the HIV-1 genome conversion through mutant tRNALys3 may constitute an effective approach for development of novel therapeutics against HIV-1 replication and HIV-1-associated diseases.