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Polysome profiling reveals broad translatome remodeling during endoplasmic reticulum (ER) stress in the pathogenic fungus Aspergillus fumigatus.

Krishnan K, Ren Z, Losada L, Nierman WC, Lu LJ, Askew DS.

Citation

Krishnan K, Ren Z, Losada L, Nierman WC, Lu LJ, Askew DS. (2014) Polysome profiling reveals broad translatome remodeling during endoplasmic reticulum (ER) stress in the pathogenic fungus Aspergillus fumigatus. BMC Genomics 15(1):159.


Abstract

Together, these findings define a core set of mRNAs subject to translational control during the adaptive response to acute ER stress in A. fumigatus and reveal a remarkable breadth of functions that are needed to resolve ER stress in this organism.


Link: http://www.ncbi.nlm.nih.gov/pubmed/24568630
PMID: 24568630
PMCID: PMC3943501