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George S.N. Hui, Ph.D.

Director, Molecular and Cellular Immunology Core
Professor
Department of Tropical Medicine, Medical Microbiology and Pharmacology
John A. Burns School of Medicine


Phone: 808-692-1609
Office: BSB 320K
Email: ghui [at] hawaii.edu
Curriculum Vitae

Bio

Academic Positions:
1987 - 1991 Assistant Research Professor, Department of Tropical Medicine, University of Hawaii
1991 - 1996 Associate Research Professor, Department of Tropical Medicine, University of Hawaii
1995 - 1996 NIH-TMRC Visiting Scientist, Research Institutes for Tropical Medicine, Philippines
1996 - present Research Professor (with tenure), Department of Tropical Medicine, University of Hawaii

Other Research-Related Positions/Memberships:
1991 - 2000 American Society of Tropical Medicine & Hygiene, member
1994 - 1996 American Society of Tropical Medicine & Hygiene, Scientific Program Committee
1994 - 1996 Chairperson, University of Hawaii, System-wide Animal Care and Use Committee
1998 Ad hoc Consultant, Trop.Diseases Res. (TDR), WHO, Vaccine Discovery Research
1997 - 1999 University of Hawaii Committee on Human Subjects (IRB)
1999 External grant review consultant for the Austrian Science Fund
1999 - present Consultant, Hawaii Biotechnology Inc.
2005 - present Consultant, Neugenesis Inc.
2008 President. American Society for Microbiology, Hawai`i Branch
2009-present External consultant for AIBS, Military Malaria Vaccine Program

NIH Study Sections:
1999 NIAID/NIH, Tropical Medicine & Parasitology (TMP) Special Study Section for RFA
1997, 2000, 02-03 NIAID/NIH, Vaccine Study Section (VAC 01, VAC 04, VAC 10)
2003 NIAID/NIH, SEP, Member of parent panel, and Sub-committee Chair, Regional Centers of Excellence for Biodefense and Emerging Infectious Diseases (RCE)
2004 NIAID, SEP, Operation of a Facility for Testing of Malaria Vaccines in Adult Human Subjects
2006 CSR/NIH, ZRG1 IMM-K (13) B, Influenza Vaccine Development
2006 NIAID/NIH, ZAI1-MH-M-C2. Malaria Vaccine Production and Support Services
2004 - 2009 CSR/NIH, Vaccines for Microbial Diseases (VMD)
2010 NIAID/NIH, ZAI1 AWA-M, M2. SEP. International Center of Excellence for Malaria Research
CSR/NIH, ZRG1 IMM-G 12B Small Business Grant Microbial Vaccine Development
2010 - 2011 CSR/NIH, ZRG1 ZRG1 IMM-F07-C(20)L B cell Regulation & Tolerance to Cancer Antigens
2011 CSR/NIH, Bioengineering & Biosciences IRG, Biomaterials and Biointerfaces
CSR/NIH, ZRG1 IMM-K(02)M, Immunology

Research Keywords: Malaria, vaccine, adjuvant


Research Overview

My research is on the development of blood stage malaria vaccines; and studies on the use of different vaccine adjuvants for the malaria vaccines. Specifically, we focus on the design of vaccines based on the Merozoite Surface Protein 1 (MSP1) by defining critical T and B epitopes of the molecule. We also evaluate the use of a variety of immunological adjuvants to enhance vaccine potency and at the same time define the critical pathway for adjuvants’ mode of action. Our approaches also study the use of nanoparticle platforms for antigen delivery.

Beside research, I am also the director of a biomedical sciences research training program for high school and college bound students called the STEP-UP Program (http://stepup.niddk.nih.gov) that is supported by NIDDK/NIH. The project recruits minority and disadvantage students from the Pacific Regions, Alaska and Puerto Rico into university/college research laboratories to engage in health related research under the mentorships of university faculty.

Selected Publications

Grants

  • Grant No / Title: 2R25DK078386-11 / Pacific High Schools STEP-UP to Biomedical Research
    Status / Agency: Awarded / NIH/NIDDK
    Start Date / End Date: 01 March 2017 / 28 February 2022
  • Grant No / Title: R25DK078386 / Pacific High Schools STEP-UP to Biomedical Research
    Status / Agency: Awarded / NIH/NIDDK
    Start Date / End Date: 01 April 2012 / 31 March 2017