Richard Yanagihara, M.D., M.P.H.
Principal Investigator Professor Department of Pediatrics John A. Burns School of Medicine
Phone: 808-692-1610
Office: BSB 320L
Email: ryanagih [at] hawaii.edu
Bio
Education
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1968 |
B.A. |
University of Hawaii at Manoa, Honolulu, Hawaii |
1972 |
M.D. |
University of Cincinnati, College of Medicine, Cincinnati, Ohio |
1985 |
M.P.H. |
Johns Hopkins University, School of Hygiene and Public Health, Baltimore, Maryland |
Professional History
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1971 |
Student Intern, Pasgeboren, Sophia Kinderziekenhuis, Rotterdam, the Netherlands (Henryk K.A. Visser, M.D.) |
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Student Intern, Sheffield Children’s Hospital, Western Bank, Sheffield, England (Ronald S. Illingworth, M.D.) |
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Student Intern, Division of Infectious Diseases, Department of Medicine, Yale University, School of Medicine, New Haven, Connecticut (Robert H. Gifford, Jr., M.D.) |
1972-1973 |
Intern, Pediatrics (PL-1), Department of Pediatrics, University of Colorado Medical Center, Denver, Colorado (C. Henry Kempe, M.D.) |
1973-1974 |
Resident, Pediatrics (PL-2), Department of Pediatrics, University of Colorado Medical Center, Denver, Colorado (Frederick C. Battaglia, M.D.) |
1974-1976 |
Research Associate, Laboratory of Central Nervous System Studies, National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, Bethesda, Maryland (D. Carleton Gajdusek, M.D.) |
1976-1977 |
Resident, Pediatrics (PL-3), Department of Pediatrics, University of California at San Francisco, San Francisco, California (Melvin M. Grumbach, M.D.) |
1977-1979 |
Fellow, Division of Infectious Diseases, Department of Pediatrics, University of Colorado Health Sciences Center, Denver, Colorado (Kenneth McIntosh, M.D.) |
1979-1982 |
Research Physician, NINCDS Research Center, Tamuning, Guam, and Laboratory of Central Nervous System Studies, National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, Bethesda, Maryland |
1982-1984 |
Special Expert, Laboratory of Central Nervous System Studies, National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, Bethesda, Maryland |
1985-1988 |
Medical Officer (tenured) and Project Officer, Laboratory of Central Nervous System Studies, National Institute of Neurological Disorders and Stroke, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, Maryland |
1988-1990 |
Senior Investigator and Project Officer, Laboratory of Central Nervous System Studies, National Institute of Neurological Disorders and Stroke, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, Maryland |
1990-1995 |
Section Chief (Research) and Project Officer, Laboratory of Central Nervous System Studies, National Institute of Neurological Disorders and Stroke, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, Maryland |
1995-2002 |
Director, Retrovirology Research Laboratory, Research Centers in Minority Institutions Program, Pacific Biomedical Research Center, University of Hawaii at Manoa, Honolulu, Hawaii |
1996-2001 |
Leader, Human Retroviruses and Other Emerging Pathogens Activity, Research Centers in Minority Institutions Program, Pacific Biomedical Research Center, University of Hawaii at Manoa, Honolulu, Hawaii |
1999-2000 |
Associate Program Director, Research Centers in Minority Institutions Program, Pacific Biomedical Research Center, University of Hawaii at Manoa, Honolulu, Hawaii |
2000-2011 |
Director, Research Centers in Minority Institutions Program, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, Hawaii |
2002-present |
Professor (tenured), Department of Pediatrics, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, Hawaii |
Research Keywords: Hantaviridae, viral zoonoses, Eulipotyphla, Chiroptera
Research Overview
Formerly a tenured intramural NIH investigator, Dr. Richard Yanagihara joined the Research Centers in Minority Institutions (RCMI) program at the University of Hawaii at Manoa through an interagency personnel agreement in 1995 to assist in building capacity for a laboratory-based retrovirology research program. He has served as the RCMI Program Director since 2000 and as the principal investigator of the Pacific Center for Emerging Infectious Diseases Research since 2003. As such, he has played a critical role in coordinating the development of much-needed infrastructure for infectious diseases research, which has involved direct mentoring of junior and mid-career faculty, as well as developing programs that award modest grant support for pilot projects, as well as bridging funds to faculty who are transitioning off of career development or departmental institutional support. Prior to joining the University of Hawaii at Manoa, Dr. Yanagihara was the on-site NINDS Project Officer of a ABSL-3/BSL-3 primate facility within the Laboratory of Central Nervous System Studies in Frederick, Maryland, where he supervised postdoctoral fellows and visiting scientists. His scientific explorations have taken the form of problem-based, disease-oriented, long-term, high-risk, multidisciplinary, opportunistic investigations of medically urgent phenomena of worldwide importance, conducted largely in the context of exploiting naturally occurring paradigms of high-incidence “place diseases” among human populations isolated by virtue of their genetics, culture and/or geography.
Selected Publications
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Hu L, Chen S, Fu Y, Gao Z, Long H, Wang J, Ren H, Zuo Y, Li H, Xu Q, Yu W, Liu J, Shao C, Hao J, Wang C, Ma Y, Wang Z, Yanagihara R, Deng Y.
Risk factors associated with clinical outcomes in 323 COVID-19 hospitalized patients in Wuhan, China
Clinical Infectious Diseases
2020
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Liphardt SW, Kang HJ, Arai S, Gu SH, Cook JA, Yanagihara R
Reassortment between divergent strains of Camp Ripley virus (Hantaviridae) in the northern short-tailed shrew (Blarina brevicauda)
Frontiers in Cellular and Infection Microbiology
2020
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Arai S, Aoki K, Nguyen ST, Vuong TV, Kikuchi F, Kinoshita G, Fukui D, Hoang TT, Gu SH, Yoshikawa Y, Tanaka-Taya K, Morikawa S, Yanagihara R, Oishi K.
Dakrong virus, a novel mobatvirus (Hantaviridae) harbored by the Stoliczka’s Asian trident bat (Aselliscus stoliczkanus) in Vietnam.
Scientific Reports
2019
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Arai S, Kikuchi F, Bawm S, Son NT, Lin KS, Tu VT, Aoki K, Tsuchiya K, Tanaka-Taya K, Morikawa S, Oishi K, Yanagihara R.
Molecular phylogeny of mobatviruses (Hantaviridae) in Myanmar and Vietnam.
Viruses
2019
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Kang HJ, Gu SH, Yashina LN, Cook JA, Yanagihara R.
Highly divergent genetic variants of soricid-borne Altai virus (Hantaviridae) in Eurasia suggest ancient host-switching events.
Viruses
2019
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Liphardt SW, Kang HJ, Dizney LJ, Ruedas LA, Cook JA, Yanagihara R.
Complex history of codiversification and host switching of a newfound soricid-borne orthohantavirus in North America.
Viruses
2019
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Dunnum JL, Yanagihara R, Johnson KM, Armien B, Batsaikhan N, Morgan L, Cook JA.
Biospecimen repositories and integrated databases as critical infrastructure for pathogen discovery and pathobiology research.
PLoS Neglected Tropical Diseases
2017
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Yanagihara R, Nerurkar VR, Hui G, Jacobs GA.
Pacific Center for Emerging Infectious Diseases Research.
Hawaii Journal of Medicine and Public Health
2017
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Arai S, Kang HJ, Gu SH, Ohdachi SD, Cook JA, Yashina LN, Tanaka-Taya K, Abramov SA, Morikawa S, Okabe N, Oishi K, Yanagihara R.
Genetic diversity of Artybash virus in the Laxmann’s shrew (Sorex caecutiens).
Vector Borne and Zoonotic Diseases
2016
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Arai S, Taniguchi S, Aoki K, Yoshikawa Y, Kyuwa S, Tanaka-Taya K, Masangkay JS, Omatsu T, Puentespina R, Watanabe S, Alviola P, Alvarez J, Eres E, Cosico E, Quibod MN, Morikawa S, Yanagihara R, Oishi K.
Molecular phylogeny of a genetically divergent hantavirus harbored by the Geoffroy’s rousette (Rousettus amplexicaudatus), a frugivorous bat species in the Philippines.
Infection Genetics and Evolution
2016
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Gu SH, Arai S, Yu HT, Lim BK, Kang HJ, Yanagihara R.
Genetic variants of Cao Bang hantavirus in the Chinese mole shrew (Anourosorex squamipes) and Taiwanese mole shrew (Anourosorex yamashinai).
Infection Genetics and Evolution
2016
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Gu SH, Kumar M, Sikorska B, Hejduk J, Markowski J, Markowski M, Liberski PP, Yanagihara R.
Isolation and partial characterization of a highly divergent lineage of hantavirus from the European mole (Talpa europaea).
Scientific Reports
2016
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Kang HJ, Gu SH, Cook JA, Yanagihara R.
Dahonggou Creek virus, a divergent lineage of hantavirus harbored by the long-tailed mole (Scaptonyx fusicaudus).
Tropical Medicine and Health
2016
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Tsunoda I, Omura S, Sato F, Kusunoki S, Fujita M, Park A-M, Hasanovic F, Yanagihara R, Nagata S.
Neuropathogenesis of Zika virus infection: Potential role of antibody-mediated pathology.
Acta Medica Kindai University
2016
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Gu SH, Hejduk J, Markowski J, Markowski M, Liberski PP, Yanagihara R.
Whole-genome sequence of a novel hantavirus isolated from the European mole (Talpa europaea).
Genome Announcements
2015
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Gu SH, Kim YS, Baek LJ, Kurata T, Yanagihara R, Song JW.
Lethal disease in infant and juvenile Syrian hamsters experimentally infected with Imjin virus, a newfound crocidurine shrew-borne hantavirus.
Infection, Genetics and Evolution
2015
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Yashina LN, Abramov SA, Dupal TA, Danchinova GA, Malyshev BS, Hay J, Gu SH, Yanagihara R.
Hokkaido genotype of Puumala virus in the grey red-backed vole (Myodes rufocanus) and northern red-backed vole (Myodes rutilus) in Siberia.
Infection, Genetics and Evolution
2015
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Bennett SN, Gu SH, Kang HJ, Arai S, Yanagihara R.
Reconstructing the evolutionary origins and phylogeography of hantaviruses.
Trends in Microbiology
2014
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Gu SH, Dormion J, Hugot JP, Yanagihara R.
High prevalence of Nova hantavirus infection in the European mole (Talpa europaea) in France.
Epidemiology and Infection
2014
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Gu SH, Hejduk J, Markowski J, Kang HJ, Markowski M, Polatynska M, Sikorska B, Liberski PP, Yanagihara R.
Co-circulation of soricid- and talpid-borne hantaviruses in Poland.
Infection, Genetics and Evolution
2014
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Gu SH, Lim BK, Kadjo B, Arai S, Kim JA, Nicolas V, Lalis A, Denys C, Cook JA, Dominguez SR, Holmes KV, Urushadze L, Sidamonidze K, Putkaradze D, Kuzmin IV, Kosoy MY, Song JW, Yanagihara R.
Molecular phylogeny of hantaviruses harbored by insectivorous bats in Cote d’Ivoire and Vietnam.
Viruses
2014
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Hugot J, Gu SH, Feliu C, Ventur J, Ribas A, Dormion J, Yanagihara R, Nicolas V.
Genetic diversity of Talpa europaea and Nova hantavirus (NVAV) in France.
Bulletin de l'Academie Veterinaire de France
2014
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Kang HJ, Stanley WT, Esselstyn JA, Gu SH, Yanagihara R.
Expanded host diversity and geographic distribution of hantaviruses in sub-Saharan Africa.
Journal of Virology
2014
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Kaufusi PH, Kelley JF, Yanagihara R, Nerurkar VR.
Induction of endoplasmic reticulum-derived replication-competent membrane structures by West Nile virus non-structural protein 4B.
PLoS One
2014
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Lee JG, Gu SH, Baek LJ, Shin OS, Kim HC, Klein TA, Yanagihara R, Song JW.
Whole-genome sequence of Muju virus, an arvicolid rodent-borne hantavirus.
Genome Announcements
2014
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Lee JG, Gu SH, Baek LJ, Shin OS, Park KS, Kim HC, Klein TA, Yanagihara R, Song JW.
Muju virus, harbored by Myodes regulus in Korea, might represent a genetic variant of Puumala virus, the prototype arvicolid rodent-borne hantavirus.
Viruses
2014
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Shin OS, Song GS, Kumar M, Yanagihara R, Lee HW, Song JW.
Hantaviruses induce antiviral and pro-inflammatory innate immune responses in astrocytic cells and the brain.
Viral Immunology
2014
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Yanagihara R, Gu SH, Arai S, Kang HJ, Song JW.
Hantaviruses: rediscovery and new beginnings.
Virus Research
2014
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Arai S, Nguyen ST, Boldgiv B, Fukui D, Araki K, Dang CN, Ohdachi SD, Nguyen NX, Pham TD, Boldbaatar B, Satoh H, Yoshikawa Y, Morikawa S, Tanaka-Taya K, Yanagihara R, Oishi K.
Novel bat-borne hantavirus, Vietnam.
Emerging Infectious Diseases
2013
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Gu SH, Markowski J, Kang HJ, Hejduk J, Sikorska B, Liberski PP, Yanagihara R.
Boginia virus, a newfound hantavirus harbored by the Eurasian water shrew (Neomys fodiens) in Poland.
Virology Journal
2013
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Gu SH, Nicolas V, Lalis A, Sathirapongsasuti N, Yanagihara R.
Complete genome sequence and molecular phylogeny of a newfound hantavirus harbored by the Doucet’s musk shrew (Crocidura douceti) in Guinea.
Infection, Genetics and Evolution
2013
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Noh JY, Cheong HJ, Song JY, Kim WJ, Song KJ, Klein TA, Lee SH, Yanagihara R, Song JW.
Clinical and molecular epidemiological features of hemorrhagic fever with renal syndrome in Korea over a 10-year period.
Journal of Clinical Virology
2013
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Shin OS, Kumar M, Yanagihara R, Song JW.
Hantaviruses induce cell type- and viral species-specific host microRNA expression signatures.
Virology
2013
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Yashina LN, Danchinova GA, Seregin SV, Khasnatinov MA, Yanagihara R.
Genetic analysis of Hokkaido hantavirus among Myodes rufocanus in the Baikal Lake area.
Bulletin of Eastern Siberian Scientific Center
2013
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Arai S, Gu SH, Baek LJ, Tabara K, Bennett SN, Oh HS, Takada N, Kang HJ, Tanaka-Taya K, Morikawa S, Okabe N, Yanagihara R, Song JW.
Divergent ancestral lineages of newfound hantaviruses harbored by phylogenetically related crocidurine shrew species in Korea.
Virology
2012
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Shin OS, Yanagihara R, Song J-W.
Distinct innate immune responses in human macrophages and endothelial cells infected with shrew-borne hantaviruses.
Virology
2012
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Sumibcay L, Kadjo B, Gu SH, Kang HJ, Lim BK, Cook JA, Song JW, Yanagihara R.
Divergent lineage of a novel hantavirus in the banana pipistrelle (Neoromicia nanus) in Cote d’Ivoire.
Virology Journal
2012
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Gu SH, Kang HJ, Baek LJ, Noh JY, Kim HC, Klein TA, Yanagihara R, Song JW.
Genetic diversity of Imjin virus in the Ussuri white-toothed shrew (Crocidura lasiura) in the Republic of Korea, 2004-2010.
Virology Journal
2011
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Kang HJ, Bennett SN, Hope AG, Cook JA, Yanagihara R.
Shared ancestry between a newfound mole-borne hantavirus and hantaviruses harbored by cricetid rodents.
Journal of Virology
2011
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Kang HJ, Kadjo B, Dubey S, Jacquet F, Yanagihara R.
Molecular evolution of Azagny virus, a newfound hantavirus harbored by the West African pygmy shrew (Crocidura obscurior) in Cote d’Ivoire.
Virology Journal
2011
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Kang HJ, Kosoy MY, Shrestha SK, Shrestha MP, Pavlin JA, Gibbons RV, Yanagihara R.
Genetic diversity of Thottapalayam virus, a hantavirus harbored by the Asian house shrew (Suncus murinus) in Nepal.
American Journal of Tropical Medicine and Hygiene
2011
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Kang HJ, Arai S, Hope AG, Cook JA, Yanagihara R.
Novel hantavirus in the flat-skulled shrew (Sorex roboratus).
Vector Borne and Zoonotic Diseases
2010
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Rai MA, Nerurkar VR, Khoja S, Khan S, Yanagihara R, Rehman A, Kazmi SU, Ali SH.
Evidence for a “founder effect” among HIV-infected injection drug users (IDUs) in Pakistan.
BMC Infectious Diseases
2010
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Yashina LN, Abramov SA, Gutorov VV, Dupal TA, Krivopalov AV, Panov VV, Danchinova GA, Vinogradov VV, Luchnikova EM, Hay J, Kang HJ, Yanagihara R.
Seewis virus: phylogeography of a shrew-borne hantavirus in Siberia, Russia.
Vector Borne and Zoonotic Diseases
2010
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Garruto RM, Yanagihara R.
Contributions of isolated Pacific populations to understanding neurodegenerative diseases.
Folia Neuropathologica
2009
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Kang HJ, Arai S, Hope AG, Song JW, Cook JA, Yanagihara R.
Genetic diversity and phylogeography of Seewis virus in the Eurasian common shrew in Finland and Hungary.
Virology Journal
2009
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Kang HJ, Bennett SN, Dizney L, Sumibcay L, Arai S, Ruedas LA, Song JW, Yanagihara R.
Host switch during evolution of a genetically distinct hantavirus in the American shrew mole (Neurotrichus gibbsii).
Virology
2009
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Kang HJ, Bennett SN, Sumibcay L, Arai S, Hope AG, Mocz G, Song JW, Cook JA, Yanagihara R.
Evolutionary insights from a genetically divergent hantavirus harbored by the European common mole (Talpa europaea).
PLoS One
2009
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Song JW, Kang HJ, Gu SH, Moon SS, Bennett SN, Song KJ, Baek LJ, Kim HC, O'Guinn ML, Chong ST, Klein TA, Yanagihara R.
Characterization of Imjin virus, a newly isolated hantavirus from the Ussuri white-toothed shrew (Crocidura lasiura).
Journal of Virology
2009
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Yanagihara R, Chang L, Ernst T.
Building infrastructure for HIV/AIDS and mental health research at institutions serving minorities.
American Journal of Public Health
2009
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Arai S, Bennett SN, Sumibcay L, Cook JA, Song JW, Hope A, Parmenter C, Nerurkar VR, Yates TL, Yanagihara R.
Phylogenetically distinct hantaviruses in the masked shrew (Sorex cinereus) and dusky shrew (Sorex monticolus) in the United States.
American Journal of Tropical Medicine and Hygiene
2008
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Arai S, Ohdachi SD, Asakawa M, Kang HJ, Mocz G, Arikawa J, Okabe N, Yanagihara R.
Molecular phylogeny of a newfound hantavirus in the Japanese shrew mole (Urotrichus talpoides).
Proceedings of the National Academy of Sciences USA
2008
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Verma S, Molina Y, Lo YY, Cropp B, Nakano C, Yanagihara R, Nerurkar VR.
In vitro effects of selenium deficiency on West Nile virus replication and cytopathogenicity.
Virology Journal
2008
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Yang Y, Wu C, Wu J, Nerurkar VR, Yanagihara R, Lu Y.
Inhibition of West Nile virus replication by retrovirus-delivered small interfering RNA in human neuroblastoma cells.
Journal of Medical Virology
2008
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Arai S, Song JW, Sumibcay L, Bennett SN, Nerurkar VR, Parmenter C, Cook JA, Yates TL, Yanagihara R.
Hantavirus in northern short-tailed shrew, United States.
Emerging Infectious Diseases
2007
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Okumura M, Yoshimatsu K, Kumperasart S, Nakamura I, Ogino M, Taruishi M, Sungdee A, Pattamadilok S, Ibrahim IN, Erlina S, Agui T, Yanagihara R, Arikawa J.
Development of serological assays for Thottapalayam virus, an insectivore-borne hantavirus.
Clinical and Vaccine Immunology
2007
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Song JW, Baek LJ, Schmaljohn CS, Yanagihara R.
Thottapalayam virus, a prototype shrewborne hantavirus.
Emerging Infectious Diseases
2007
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Song JW, Gu SH, Bennett SN, Arai S, Puorger M, Hilbe M, Yanagihara R.
Seewis virus, a genetically distinct hantavirus in the Eurasian common shrew (Sorex araneus).
Virology Journal
2007
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Song JW, Kang HJ, Song KJ, Truong TT, Bennett SN, Arai S, Truong NU, Yanagihara R.
Newfound hantavirus in Chinese mole shrew, Vietnam.
Emerging Infectious Diseases
2007
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Song KJ, Baek LJ, Moon S, Ha SJ, Kim SH, Park KS, Klein TA, Sames W, Kim HC, Lee JS, Yanagihara R, Song JW.
Muju virus, a novel hantavirus harboured by the arvicolid rodent Myodes regulus in Korea.
Journal of General Virology
2007
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Baek LJ, Kariwa H, Lokugamage K, Yoshimatsu K, Arikawa J, Takashima I, Kang JI, Moon SS, Chung SY, Kim EJ, Kang HJ, Song KJ, Klein TA, Yanagihara R, Song JW.
Soochong virus: an antigenically and genetically distinct hantavirus isolated from Apodemus peninsulae in Korea.
Journal of Medical Virology
2006
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Friedlaender J, Schurr T, Gentz F, Koki G, Friedlaender F, Horvat G, Babb P, Cerchio S, Kaestle F, Schanfield M, Deka R, Yanagihara R, Merriwether DA.
Expanding Southwest Pacific mitochondrial haplogroups P and Q.
Molecular Biology and Evolution
2005
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Song JW, Baek LJ, Song KJ, Skrok A, Markowski J, Bratosiewicz-Wasik J, Kordek R, Liberski PP, Yanagihara R.
Characterization of Tula virus from common voles (Microtus arvalis) in Poland: evidence for geographic-specific phylogenetic clustering.
Virus Genes
2004
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Grants
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Grant No / Title: P30GM114737 / Pacific Center for Emerging Infectious Diseases Research
Status / Agency: Awarded / NIH/NIGMS
Start Date / End Date: 01 July 2015 / 30 June 2020
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Grant No / Title: P20GM103516 / Pacific Center for Emerging Infectious Diseases Research
Status / Agency: Ongoing / NIH/NIGMS
Start Date / End Date: 16 September 2010 / 30 June 2015
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Grant No / Title: R01AI075057 / Intraspecies Transmission and Infectivity of Insectivore-Borne Hantaviruses
Status / Agency: Ongoing / NIH/NIAID
Start Date / End Date: 08 August 2008 / 31 July 2014
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