Vivek R. Nerurkar, Ph.D.
Director, Biocontainment Core Professor and Chair Department of Tropical Medicine, Medical Microbiology and Pharmacology John A. Burns School of Medicine
Phone: 808-692-1668
Office: BSB 320G
Email: nerurkar [at] pbrc.hawaii.edu
External Homepage
Curriculum Vitae
Bio
Education
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1980 |
B.Sc. Biology, Chemistry, Physics; First Class |
University of Bombay, Bombay, India |
1981 |
D.M.L.T. Diploma in Medical Laboratory Technology |
University of Bombay, Bombay, India |
1983 |
M.Sc. Zoology (Animal Physiology); First Class |
University of Bombay, Bombay, India |
1987 |
Ph.D. Applied Biology (Cell and Molecular Biology) |
Comparative Oncology Unit, Cancer Research Institute, University of Bombay, Bombay, India |
Professional History
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1981 |
Technical Assistant, Department of Pathology and Clinical Biochemistry, Lokmanaya Tilak Medical College and Hospital, Bombay, India |
1981 - 1983 |
Technical Assistant, Indian Red Cross, Bombay, India |
1987 |
Research Associate, Department of Cell and Developmental Pathology, Cancer Research Institute, Bombay, India |
1987 - 1989 |
Research Associate, Cancer Center, University of Rochester, Rochester, New York |
1989 |
Postdoctoral Fellow, Department of Biological Sciences, State University of New York at Buffalo, Buffalo, New York |
1989 - 1992 |
Visiting Fellow, Fogarty International Center (FIC), Laboratory of Central Nervous System Studies (LCNSS), National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH), Bethesda, Maryland |
1992 - 1993 |
Visiting Associate, FIC, LCNSS, NINDS, NIH, Bethesda, Maryland |
1993 - 1994 |
Guest Researcher, FIC, LCNSS, NINDS, NIH, Bethesda, Maryland |
1994 - 1996 |
Assistant Researcher (Virology), Retrovirology Research Laboratory (RRL), Pacific Biomedical Research Center (PBRC), University of Hawaii at Manoa (UHM), Honolulu, Hawaii |
1995 |
Acting Director, RRL, PBRC, UHM, Honolulu, Hawaii |
1996 - 2000 |
Associate Professor, Interdisciplinary Biomedical Sciences Graduate Program, UHM, Honolulu, Hawaii |
1996 - 2003 |
Associate Researcher (Virology), RRL, PBRC, UHM, Honolulu, Hawaii |
1998 - 1999 |
Associate Professor, Department of Epidemiology, School of Public Health, UHM, Honolulu, Hawaii |
1999 - 2003 |
Associate Professor, Department of Public Health Sciences and Epidemiology, John A. Burns School of Medicine (JABSOM), UHM, Honolulu, Hawaii |
2000 - 2003 |
Associate Professor, Cell and Molecular Biology (CMB) Graduate Program, and Tropical Medicine and Medical Microbiology (TMMM) Graduate Program, JABSOM, UHM, Honolulu, Hawaii |
2001 - 2003 |
Associate Professor, Microbiology Department Graduate Program, College of Natural Sciences, UHM, Honolulu, Hawaii |
2001 - 2006 |
Activity Leader, Pathobiology of HIV-Associated Disorders, NIH-NCRR Research Centers in Minority Institutions (RCMI) Program, JABSOM, UHM, Honolulu, Hawaii |
2002 - 2003 |
Associate Professor, Molecular Biosciences and Biosystems Engineering (MBBE) Graduate Program, College of Tropical Agriculture and Human Resources UHM, Honolulu, Hawaii |
2002 - 2004 (Sept) |
Member, PBRC Executive Committee, PBRC, UHM, Honolulu, Hawaii |
2002 - Present |
Director, RRL, PBRC/JABSOM, UHM, Honolulu, Hawaii |
2003 (July) |
Researcher (Virology), RRL, PBRC, UHM, Honolulu, Hawaii |
2003 (Sept) - Present |
Professor, Department of Tropical Medicine and Medical Microbiology, JABSOM, UHM, Honolulu, Hawaii |
2003 - Present |
Professor, Microbiology, CMB, MBBE, TMMM, and Epidemiology Graduate Programs, UHM, Honolulu, Hawaii |
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Director Technical Core, Pacific Center for Emerging Infectious Diseases Research, Center of Biomedical Research Excellence NIH-NCRR, JABSOM, UHM, Honolulu, Hawaii |
2005 (July) - Present |
Professor (Tenured), Department of Tropical Medicine, Medical Microbiology and Pharmacology, JABSOM, UHM, Honolulu, Hawaii |
2006 - 2008 |
Associate Activity Leader, Tropical Infectious Diseases Detection and Prevention Core (TDDPC) activity, NIH-NCRR RCMI, JABSOM, UHM, Honolulu, Hawaii |
2008 (Aug) - Present |
Activity Leader, TDDPC activity, NIH-NCRR RCMI Program, JABSOM, UHM, Honolulu, Hawaii |
2008 (Nov) - Present |
Interim Chair, Department of Tropical Medicine, Medical Microbiology and Pharmacology, JABSOM, UHM, Honolulu, Hawaii |
2009 - 2010 |
President-Elect, Amercian Society for Microbiology Hawaii Chapter, Honolulu, Hawaii |
2009 (Feb) - Present |
Director, Biocontainment Facility, JABSOM, UHM, Honolulu, Hawaii |
2010 (Jan) - Present |
Chair, Department of Tropical Medicine, Medical Microbiology and Pharmacology, JABSOM, UHM, Honolulu, Hawaii |
2010 (April) - Present |
President, Amercian Society for Microbiology Hawaii Chapter, Honolulu, Hawaii |
Research Keywords: Molecular virology, arbovirology, viral diagnostics
Research Overview
Dr. Vivek R. Nerurkar, who joined the University of Hawaii at Manoa (UHM) in 1994, to develop the Research Centers in Minority Institutions (RCMI), NCRR-supported Retrovirology Activity following a five-year appointment as a Visiting Fellow and Visiting Associate of the NINDS, NIH, has mentored over 100 undergraduate and graduate students, technicians and postdoctoral fellows in laboratory-based research during the past 25 years. Dr. Nerurkar’s major area of research interest is in infectious diseases, specifically to study the pathogenesis of orphan diseases and orphan microbial agents. Over the past two decades he has conducted research in the diverse but related areas of virology, specifically neurovirology. Dr. Nerurkar conducts research on pathogenesis of West Nile virus-associated meningoencephalitis and pathogenesis of the fatal demyelinating disease, progressive multifocal leukoencephalopathy (PML). A talented virologist, Dr. Nerurkar, has extensive experience in classical and molecular microbiological techniques, as documented in publications appearing in peer-reviewed journals and in successful grant applications from local and national agencies. He has utilized molecular methods to study a wide range of emerging and re-emerging microbial pathogens. Dr. Nerurkar has collaborated nationally and internationally with investigators from various ethnic backgrounds. He has extensive experience of conducting research in international arena and his abilities to train minority students, enrolled at the UHM (a minority institution) and international students and postdoctoral fellows, is well documented in the form of collaborative publications. He is member of the graduate faculty of the Department of Cell and Molecular Biology (CMB), JABSOM; Department of Molecular Biosciences and Biosystems Engineering (MBBE), College of Tropical Agriculture and Human Resources (CTAHR); and Department of Microbiology, College of Natural Sciences (CNS), UHM. He is part of the NIH Short Term Education Program for Underrepresented Persons (STEP UP) Summer program, which trains high school and undergraduate students in laboratory research. He is also a mentor of the NIMH, NIH R25 grant, which trains minorities and other disadvantaged students and faculty in conducting research on mental health related issues. Dr. Nerurkar will serve as a Core Director and Mentor on this proposal.
Selected Publications
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Haun BK, Kamara V, Dweh AS, Garalde-Machida K, Forkay SSE, Takaaze M, Namekar M, Wong TAS, Bell-Gam Woto AER, Humphreys P, Weeks OI, Fallah MP, Berestecky JM, Nerurkar VR, Lehrer AT.
Serological evidence of Ebola virus exposure in dogs from affected communities in Liberia: a preliminary report.
PLoS Neglected Tropical Diseases
2019
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Krause K, Azouz F, Nakano E, Nerurkar VR, Kumar M.
Deletion of pregnancy zone protein and murinoglobulin-1 restricts the pathogenesis of West Nile virus infection in mice.
Frontiers in Microbiology
2019
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Lloyd YM, Esemu LF, Antallan J, Thomas B, Tassi Yunga S, Obase B, Christine N, Leke RGF, Culleton R, Mfuh KO, Nerurkar VR, Taylor DW.
PCR-based detection of Plasmodium falciparum in saliva using mitochondrial cox3 and varATS primers.
Tropical Medicine and Health
2018
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To A, Medina LO, Mfuh KO, Lieberman MM, Wong TAS, Namekar M, Nakano E, Lai CY, Kumar M, Nerurkar VR, Lehrer AT.
Recombinant Zika virus subunits are immunogenic and efficacious in mice.
mSphere
2018
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Kumar M, Krause KK, Azouz F, Nakano E, Nerurkar VR.
A guinea pig model of Zika virus infection.
Virology Journal
2017
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Mfuh KO, Yunga ST, Esemu LF, Bekindaka ON, Yonga J, Djontu JC, Mbakop CD, Taylor DW, Nerurkar VR, Leke RGF.
Detection of Plasmodium falciparum DNA in saliva samples stored at room temperature: potential for a non-invasive saliva-based diagnostic test for malaria.
Malaria Journal
2017
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Yanagihara R, Nerurkar VR, Hui G, Jacobs GA.
Pacific Center for Emerging Infectious Diseases Research.
Hawaii Journal of Medicine and Public Health
2017
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Achonduh-Atijegbe OA, Mfuh KO, Mbange AH, Chedjou JP, Taylor DW, Nerurkar VR, Mbacham WF, Leke R.
Prevalence of malaria, typhoid, toxoplasmosis and rubella among febrile children in Cameroon.
BMC Infectious Diseases
2016
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Culjat M, Darling SE, Nerurkar VR, Ching N, Kumar M, Min SK, Wong R, Grant L, Melish ME.
Clinical and imaging findings in an infant with Zika embryopathy.
Clinical Infectious Diseases
2016
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Kaufusi PH, Tseng A, Nerurkar VR.
Functional analysis of West Nile virus proteins in human cells.
Methods in Molecular Biology
2016
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Kumar M, Belcaid M, Nerurkar VR.
Identification of host genes leading to West Nile virus encephalitis in mice brain using RNA-seq analysis.
Scientific Reports
2016
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Kumar M, Ching L, Astern J, Lim E, Stokes AJ, Melish M, Nerurkar VR.
Antibodies to Zika virus in mothers from Hawaii who delivered babies with and without microcephaly between 2009-2012.
PLoS Neglected Tropical Diseases
2016
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Kumar M, Nerurkar VR.
In vitro and in vivo blood-brain barrier models to study West Nile virus pathogenesis.
Methods in Molecular Biology
2016
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Kumar M, Roe K, O'Connell M, Nerurkar VR
Induction of virus-specific effector immune cell response limits virus replication and severe disease in mice infected with non-lethal West Nile virus Eg101 strain.
Journal of Neuroinflammation
2015
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Ton TG, Gladding SP, Zunt JR, John C, Nerurkar VR, Moyer CA, Hobbs N, McCoy M, Kolars JC.
The development and implementation of a competency-based curriculum for training in global health research.
American Journal of Tropical Medicine and HygIene
2015
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Hsieh SC, Tsai WY, Nerurkar VR, Wang WK.
Characterization of the ectodomain of the envelope protein of dengue virus type 4: expression, membrane association, secretion and particle formation in the absence of precursor membrane protein.
PLoS One
2014
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Hsieh SC, Wu YC, Zou G, Nerurkar VR, Shi PY, Wang WK.
Highly conserved residues in the helical domain of dengue virus type 1 precursor membrane protein are involved in assembly, prM protein cleavage and entry.
Journal of Biological Chemistry
2014
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Kaufusi PH, Kelley JF, Yanagihara R, Nerurkar VR.
Induction of endoplasmic reticulum-derived replication-competent membrane structures by West Nile virus non-structural protein 4B.
PLoS One
2014
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Kumar M, Nerurkar VR.
Integrated analysis of microRNAs and their disease related targets in the brain of mice infected with West Nile virus.
Virology
2014
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Kumar M, O'Connell M, Namekar M, Nerurkar VR.
Infection with non-lethal West Nile virus Eg101 strain induces immunity that protects mice against the lethal West Nile virus NY99 strain.
Viruses
2014
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Kumar M, Roe K, Nerurkar PV, Orillo B, Thompson KS, Verma S, Nerurkar VR.
Reduced immune cell infiltration and increased pro-inflammatory mediators in the brain of Type 2 diabetic mouse model infected with West Nile virus.
Journal of Neuroinflammation
2014
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Kumar M, Roe K, Orillo B, Muruve DA, Nerurkar VR, Gale M, Verma S.
Inflammasome adaptor protein apoptosis-associated speck-like protein containing CARD (ASC) is critical for the immune response and survival in West Nile virus encephalitis.
Journal of Virology
2013
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Namekar M, Ellis EM, O'Connell M, Elm J, Gurary A, Park SY, Imrie A, Nerurkar VR.
Evaluation of a new commercially available immunoglobulin M capture enzyme-linked immunosorbent assay for diagnosis of dengue infection.
Journal of Clinical Microbiology
2013
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Wu C, Nerurkar VR, Lu Y.
New insights into inhibition of human immunodeficiency virus type 1 replication through mutant tRNALys3.
Retrovirology
2013
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Kelley JF, Kaufusi PH, Nerurkar VR.
Dengue hemorrhagic fever-associated immunomediators induced via maturation of dengue virus nonstructural 4B protein in monocytes modulate endothelial cell adhesion molecules and human microvascular endothelial cells permeability.
Virology
2012
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Kumar M, Roe K, Nerurkar PV, Namekar M, Orillo B, Verma S, Nerurkar VR.
Impaired virus clearance, compromised immune response and increased mortality in Type 2 diabetic mice infected with West Nile virus.
PLoS One
2012
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Namekar M, Kumar M, O'Connell M, Nerurkar VR.
Effect of serum heat-inactivation and dilution on detection of anti-WNV antibodies in mice by West Nile virus E-protein microsphere immunoassay.
PLoS One
2012
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Roe K, Kumar M, Lum S, Orillo B, Nerurkar VR, Verma S.
West Nile virus-induced disruption of the blood-brain barrier in mice is characterized by the degradation of the junctional complex proteins and increase in multiple matrix metalloproteinases.
Journal of General Virology
2012
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Kelley JF, Kaufusi PH, Volper EM, Nerurkar VR.
Maturation of dengue virus nonstructural protein 4B in monocytes enhances production of dengue hemorrhagic fever-associated chemokines and cytokines.
Virology
2011
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Nerurkar PV, Johns LM, Buesa LM, Kipyakwai G, Volper E, Sato R, Shah P, Feher D, Williams PG, Nerurkar VR.
Momordica charantia (bitter melon) attenuates high-fat diet-associated oxidative stress and neuroinflammation.
Journal of Neuroinflammation
2011
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Nerurkar PV, Nishioka A, Eck PO, Johns LM, Volper E, Nerurkar VR.
Regulation of glucose metabolism via hepatic forkhead transcription factor 1 (FoxO1) by Morinda citrifolia (noni) in high-fat diet-induced obese mice.
British Journal of Nutrition
2011
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Snee LS, Nerurkar VR, Dooley DA, Efird JT, Schovic AC, Nerurkar PV.
Strategies to improve palatability and increase consumption intentions for Momordica charantia (bitter melon): a vegetable commonly used for diabetes management.
Nutrition Journal
2011
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Verma S, Kumar M, Nerurkar VR.
Cyclooxygenase-2 inhibitor blocks the production of West Nile virus-induced neuroinflammatory markers in astrocytes.
Journal of General Virology
2011
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Chapagain ML, Nerurkar VR.
Human polyomavirus JC (JCV) infection of human B lymphocytes: a possible mechanism for JCV transmigration across the blood-brain barrier.
Journal of Infectious Diseases
2010
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Kumar M, Verma S, Nerurkar VR.
Pro-inflammatory cytokines derived from West Nile virus (WNV)-infected SK-N-SH cells mediate neuroinflammatory markers and neuronal death.
Journal of Neuroinflammation
2010
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Nerurkar PV, Lee YK, Nerurkar VR.
Momordica charantia (bitter melon) inhibits primary human adipocyte differentiation by modulating adipogenic genes.
BMC Complementary and Alternative Medicine
2010
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Rai MA, Nerurkar VR, Khoja S, Khan S, Yanagihara R, Rehman A, Kazmi SU, Ali SH.
Evidence for a “founder effect” among HIV-infected injection drug users (IDUs) in Pakistan.
BMC Infectious Diseases
2010
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Verma S, Kumar M, Gurjav U, Lum S, Nerurkar VR.
Reversal of West Nile virus-induced blood-brain barrier disruption and tight junction proteins degradation by matrix metalloproteinases inhibitor.
Virology
2010
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Zhang L, Qi F, Gaudino G, Strianese O, Yang H, Morris P, Pass HI, Nerurkar VR, Bocchetta M, Carbone M.
Tissue tropism of SV40 transformation of human cells: role of the viral regulatory region and of cellular oncogenes.
Genes Cancer
2010
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Lieberman MM, Nerurkar VR, Luo H, Cropp B, Carrion R, de la Garza M, Coller BA, Clements D, Ogata S, Wong T, Martyak T, Weeks-Levy C.
Immunogenicity and protective efficacy of a recombinant subunit West Nile virus vaccine in rhesus monkeys.
Clinical and Vaccine Immunology
2009
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Verma S, Lo Y, Chapagain M, Lum S, Kumar M, Gurjav U, Luo H, Nakatsuka A, Nerurkar VR.
West Nile virus infection modulates human brain microvascular endothelial cells tight junction proteins and cell adhesion molecules: Transmigration across the in vitro blood-brain barrier.
Virology
2009
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Arai S, Bennett SN, Sumibcay L, Cook JA, Song JW, Hope A, Parmenter C, Nerurkar VR, Yates TL, Yanagihara R.
Phylogenetically distinct hantaviruses in the masked shrew (Sorex cinereus) and dusky shrew (Sorex monticolus) in the United States.
American Journal of Tropical Medicine and Hygiene
2008
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Chapagain ML, Sumibcay L, Gurjav U, Kaufusi PH, Kast RE, Nerurkar VR.
Serotonin receptor 2A blocker (risperidone) has no effect on human polyomavirus JC infection of primary human fetal glial cells.
Journal of Neurovirology
2008
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Jarvi SI, Lieberman MM, Hofmeister E, Nerurkar VR, Wong T, Weeks-Levy C.
Protective efficacy of a recombinant subunit West Nile virus vaccine in domestic geese (Anser anser).
Vaccine
2008
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Verma S, Molina Y, Lo YY, Cropp B, Nakano C, Yanagihara R, Nerurkar VR.
In vitro effects of selenium deficiency on West Nile virus replication and cytopathogenicity.
Virology Journal
2008
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Yang Y, Wu C, Wu J, Nerurkar VR, Yanagihara R, Lu Y.
Inhibition of West Nile virus replication by retrovirus-delivered small interfering RNA in human neuroblastoma cells.
Journal of Medical Virology
2008
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Arai S, Song JW, Sumibcay L, Bennett SN, Nerurkar VR, Parmenter C, Cook JA, Yates TL, Yanagihara R.
Hantavirus in northern short-tailed shrew, United States.
Emerging Infectious Diseases
2007
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Grants
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Grant No / Title: 1D71TW010434-01A1 / Sustainable Research Training and Capacity Building in Liberia for Emerging Viral Epidemics
Status / Agency: Awarded / NIH/FIC
Start Date / End Date: 08 September 2017 / 31 August 2019
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Grant No / Title: 2D43TW009345-06 / Northern/Pacific Universities Global Health Research Training Consortium
Status / Agency: Awarded / NIH/FIC
Start Date / End Date: 01 July 2017 / 30 June 2022
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Grant No / Title: R21NS099838 / Defining the Function of Schlafen4 in the Pathogenesis of Flavivirus Encephalitis
Status / Agency: Awarded / NIH/NINDS
Start Date / End Date: 01 September 2016 / 31 August 2018
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Grant No / Title: T37MD008636 / International Biomedical Research Training for Hawaiian & Pacific Island Students
Status / Agency: Awarded / NIH/NIMHD
Start Date / End Date: 01 December 2013 / 30 November 2018
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Grant No / Title: R25TW009345 / Northern/Pacific Global Health Research Fellows Training Consortium
Status / Agency: Awarded / NIH/FIC
Start Date / End Date: 06 April 2012 / 31 March 2017
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Grant No / Title: 5 R01 AI075057-03 / Intraspecies Transmission and Infectivity of Insectivore-Borne Hantaviruses
Status / Agency: Ongoing / NIH/NIAID
Start Date / End Date: 08 August 2008 / 31 July 2012
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Grant No / Title: 5 U01 AI078213-03 / Multiplex Serodiagnostic Protein Microarray
Status / Agency: Ongoing / NIH/NIAID
Start Date / End Date: 01 August 2008 / 31 July 2013
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Grant No / Title: 5 R03 NS060647-02 / Migration of Polyomavirus JC Across the Blood-Brain Barrier
Status / Agency: Ongoing / NIH/NINDS
Start Date / End Date: 15 May 2008 / 30 April 2012
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Grant No / Title: 5 R25 DK078386-05 / High School Students STEP-UP to Biomedical Research
Status / Agency: Ongoing / NIH/NIDDK
Start Date / End Date: 01 April 2007 / 31 March 2012
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Grant No / Title: 5 R25 MH080661-05 / Translational Research in Neuro-AIDS and Mental Health (TR-NAMH)
Status / Agency: Ongoing / NIH/NIMH
Start Date / End Date: 01 February 2007 / 31 January 2012
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Grant No / Title: 5 G12 RR003061-25 / Research Outcomes Accelerating Discoveries for Medical Applications and Practice
Status / Agency: Ongoing / NIH/NCRR
Start Date / End Date: 01 August 2006 / 31 July 2011
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Grant No / Title: 5 P20 RR018727-07 / Pacific Center for Emerging Infectious Diseases Research
Status / Agency: Ongoing / NIH/NCRR
Start Date / End Date: 30 September 2003 / 30 June 2015
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