COBRE

Mukesh Kumar, Ph.D.

Associate Director, Biocontainment Core
Assistant Professor
Department of Tropical Medicine, Medical Microbiology and Pharmacology
John A. Burns School of Medicine

Phone: (808) 692-1671
Office:
Email: mukesh [at] hawaii.edu

Bio

Education


2007	B.V.Sc. & A.H.	(Veterinary Science) College of Verterinary Science and Animal Husbandry, Jabalpur, India
2010	M.S.	(Biomedical Sciences) University of Hawaii at Manoa, Honolulu, HI
2013	Ph.D.	(Biomedical Sciences) University of Hawaii at Manoa, Honolulu, HI

Research Keywords: Flaviviruses, pathogenesis, animal models

Selected Publications

Krause K, Azouz F, Nakano E, Nerurkar VR, Kumar M.
Deletion of pregnancy zone protein and murinoglobulin-1 restricts the pathogenesis of West Nile virus infection in mice.
Frontiers in Microbiology 2019 more details...
Kim J-A, Seong R-K, Kumar M, Shin OS.
Favipiravir and ribavirin inhibit replication of Asian and African strains of Zika virus in different cell models.
Viruses 2018 more details...
To A, Medina LO, Mfuh KO, Lieberman MM, Wong TAS, Namekar M, Nakano E, Lai CY, Kumar M, Nerurkar VR, Lehrer AT.
Recombinant Zika virus subunits are immunogenic and efficacious in mice.
mSphere 2018 more details...
Krause KK, Azouz F, Shin OS, Kumar M.
Understanding the pathogenesis of Zika virus infection using animal models.
Immune Network 2017 more details...
Kumar M, Krause KK, Azouz F, Nakano E, Nerurkar VR.
A guinea pig model of Zika virus infection.
Virology Journal 2017 more details...
Seong RK, Seo SW, Kim JA, Fletcher SJ, Morgan NV, Kumar M, Choi YK, Shin OS.
Schlafen 14 (SLFN14) is a novel antiviral factor involved in the control of viral replication.
Immunobiology 2017 more details...
Culjat M, Darling SE, Nerurkar VR, Ching N, Kumar M, Min SK, Wong R, Grant L, Melish ME.
Clinical and imaging findings in an infant with Zika embryopathy.
Clinical Infectious Diseases 2016 more details...
Gu SH, Kumar M, Sikorska B, Hejduk J, Markowski J, Markowski M, Liberski PP, Yanagihara R.
Isolation and partial characterization of a highly divergent lineage of hantavirus from the European mole (Talpa europaea).
Scientific Reports 2016 more details...
Kumar M, Belcaid M, Nerurkar VR.
Identification of host genes leading to West Nile virus encephalitis in mice brain using RNA-seq analysis.
Scientific Reports 2016 more details...
Kumar M, Ching L, Astern J, Lim E, Stokes AJ, Melish M, Nerurkar VR.
Antibodies to Zika virus in mothers from Hawaii who delivered babies with and without microcephaly between 2009-2012.
PLoS Neglected Tropical Diseases 2016 more details...
Kumar M, Nerurkar VR.
In vitro and in vivo blood-brain barrier models to study West Nile virus pathogenesis.
Methods in Molecular Biology 2016 more details...
Kim JA, Park SK, Kumar M, Lee CH, Shin OS.
Insights into the role of immunosenescence during varicella zoster virus infection (shingles) in the aging cell model.
Oncotarget 2015 more details...
Kumar M, Roe K, O'Connell M, Nerurkar VR
Induction of virus-specific effector immune cell response limits virus replication and severe disease in mice infected with non-lethal West Nile virus Eg101 strain.
Journal of Neuroinflammation 2015 more details...
Park SJ, Kumar M, Kwon HI, Seong RK, Han K, Song JM, Kim CJ, Choi YK, Shin OS.
Dynamic changes in host gene expression associated with H5N8 avian influenza virus infection in mice.
Scientific Reports 2015 more details...
Kumar M, Nerurkar VR.
Integrated analysis of microRNAs and their disease related targets in the brain of mice infected with West Nile virus.
Virology 2014 more details...
Kumar M, O'Connell M, Namekar M, Nerurkar VR.
Infection with non-lethal West Nile virus Eg101 strain induces immunity that protects mice against the lethal West Nile virus NY99 strain.
Viruses 2014 more details...
Kumar M, Roe K, Nerurkar PV, Orillo B, Thompson KS, Verma S, Nerurkar VR.
Reduced immune cell infiltration and increased pro-inflammatory mediators in the brain of Type 2 diabetic mouse model infected with West Nile virus.
Journal of Neuroinflammation 2014 more details...
Shin OS, Song GS, Kumar M, Yanagihara R, Lee HW, Song JW.
Hantaviruses induce antiviral and pro-inflammatory innate immune responses in astrocytic cells and the brain.
Viral Immunology 2014 more details...
Kumar M, Roe K, Orillo B, Muruve DA, Nerurkar VR, Gale M, Verma S.
Inflammasome adaptor protein apoptosis-associated speck-like protein containing CARD (ASC) is critical for the immune response and survival in West Nile virus encephalitis.
Journal of Virology 2013 more details...
Shin OS, Kumar M, Yanagihara R, Song JW.
Hantaviruses induce cell type- and viral species-specific host microRNA expression signatures.
Virology 2013 more details...
Kumar M, Roe K, Nerurkar PV, Namekar M, Orillo B, Verma S, Nerurkar VR.
Impaired virus clearance, compromised immune response and increased mortality in Type 2 diabetic mice infected with West Nile virus.
PLoS One 2012 more details...
Namekar M, Kumar M, O'Connell M, Nerurkar VR.
Effect of serum heat-inactivation and dilution on detection of anti-WNV antibodies in mice by West Nile virus E-protein microsphere immunoassay.
PLoS One 2012 more details...
Roe K, Kumar M, Lum S, Orillo B, Nerurkar VR, Verma S.
West Nile virus-induced disruption of the blood-brain barrier in mice is characterized by the degradation of the junctional complex proteins and increase in multiple matrix metalloproteinases.
Journal of General Virology 2012 more details...
Verma S, Hoffmann FW, Kumar M, Huang Z, Roe K, Nguyen-Wu E, Hashimoto AS, Hoffmann PR.
Selenoprotein K knockout mice exhibit deficient calcium flux in immune cells and impaired immune responses.
Journal of Immunology 2011 more details...
Verma S, Kumar M, Nerurkar VR.
Cyclooxygenase-2 inhibitor blocks the production of West Nile virus-induced neuroinflammatory markers in astrocytes.
Journal of General Virology 2011 more details...
Kumar M, Verma S, Nerurkar VR.
Pro-inflammatory cytokines derived from West Nile virus (WNV)-infected SK-N-SH cells mediate neuroinflammatory markers and neuronal death.
Journal of Neuroinflammation 2010 more details...
Verma S, Kumar M, Gurjav U, Lum S, Nerurkar VR.
Reversal of West Nile virus-induced blood-brain barrier disruption and tight junction proteins degradation by matrix metalloproteinases inhibitor.
Virology 2010 more details...

Grants

Grant No / Title: R21OD024896 / A Guinea Pig Model of Zika Virus Disease
Status / Agency: Awarded / NIH/OD
Start Date / End Date: 01 September 2017 / 31 August 2019
Grant No / Title: R21NS099838 / Defining the Function of Schlafen4 in the Pathogenesis of Flavivirus Encephalitis
Status / Agency: Awarded / NIH/NINDS
Start Date / End Date: 01 September 2016 / 31 August 2018