Date/Time: 02 March 2017, 9:00 AM - 10:00 AM
Speaker: Howard E. Gendelman, M.D.
Speaker Affiliation: Margaret R. Larson Professor of Infectious Diseases and Internal Medicine, Professor and Chair, Department of Pharmacology & Experimental Neuroscience, University of Nebraska Medical Center Omaha, Nebraska
Venue: John A. Burns School of Medicine, Medical Education Building, Room 315
For more info: Cori Watanabe 808 692-1654
Description: Advances in the development of long acting antiretroviral therapy (ART) can revolutionize current treatments for HIV/AIDS. We have coined the term long active slow effective release ART (LASER ART) based on properties of slow drug dissolution, poor water-solubility, excellent bioavailability, limited off target systemic toxicities, and excellent patient treatment adherence. Drug carrier technologies characterized by high payload of antiretroviral drugs (ARVs) in a single carrier are being developed to improve the pharmacokinetics and pharmacodynamics of the nanoformulated ART (nanoART). Additionally, surface modification of slow release antiretroviral carriers with targeting ligands has facilitated receptor-mediated transport across physiological barriers serves to improve therapeutic outcomes. The lecture will discuss the future of antiretroviral therapy where LASER ART treatments can be given once every few months and target hidden sites of sustained viral growth.
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