Publication Detail
Strategically examining the full-genome of dengue virus type 3 in clinical isolates reveals its mutation spectra.
Chao DY, King CC, Wang WK, Chen WJ, Wu HL, Chang GJ.
Citation
Chao DY, King CC, Wang WK, Chen WJ, Wu HL, Chang GJ. (2005) Strategically examining the full-genome of dengue virus type 3 in clinical isolates reveals its mutation spectra. Virology Journal 272.
Abstract
This study confirmed previous reports that the most heterogeneous region of the dengue viral genome resided at the envelope region, of which the domain III was under positive selection pressure. Further studies will need to address the influence of these mutations on the overall fitness in different hosts (i.e., mosquito and human) during dengue viral transmission.
| Link: | http://www.ncbi.nlm.nih.gov/pubmed/16120221 |
| PMID: | 16120221 |
| PMCID: | PMC1208963 |