Saguna Verma, Ph.D.
Associate Professor Department of Tropical Medicine, Medical Microbiology and Pharmacology John A. Burns School of Medicine
Phone: 808-692-1662
Office: BSB 325C
Email: saguna [at] hawaii.edu
Curriculum Vitae
Bio
Education
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1985 |
B.S. |
(Zoology, Chemistry, Botany) Devi Ahilya University, Indore, India |
1988 |
M.S. |
(Biochemistry) Devi Ahilya University, Indore, India |
1994 |
Ph.D. |
(Biochemistry) Devi Ahilya University, Indore, India |
Positions and Employment
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1989-1991 |
Junior Research Fellow, School of Life Sciences, Indore, India |
1992-1993 |
Senior Research Fellow, School of Life Sciences, Indore, India |
1994-1999 |
Project Scientist, Genes and Proteins Laboratory, National Institute of Immunology, New Delhi, India |
2000-2001 |
Guest Lecturer, Vaid’s Institute, New Delhi, India |
2003-2005 |
Junior Researcher, Retrovirology Research Laboratory, Department Tropical Medicine, Medical Microbiology and Pharmacology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, Hawaii |
2005-present |
Assistant Professor, Department Tropical Medicine, Medical Microbiology and Pharmacology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, Hawaii |
Awards and Fellowships
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1985 |
Merit Scholarship in B.Sc. by the Devi Ahilya University, Indore, India |
1989-1993 |
University Grants Commission-Council of Science and Industrial Research (UGC-CSIR) and Lecturer Eligibility Fellowship, India |
1992 |
Madhya Pradesh Council of Science and Technology, India (MPCST) YOUNG SCIENTIST, Merit certificate in 7th Young Scientist conference organized by Council of Science and Technology, India |
1992 |
Travel Award from CSIR, India, to attend the annual meeting of the Federation of American Societies for Experimental Biology, Anaheim, CA |
2004 |
Travel Award from the Retrovirology and Opportunistic Infections Society to attend the Eleventh Conference on Retroviruses and Opportunistic Infections, San Francisco, CA |
2005 |
Hawaii State-Biomedical Research Infrastructure Network (BRIN) Travel Award to attend the Eighth International Symposium on Kawasaki Disease, San Diego, CA |
Research Keywords: Neurovirology, neuroinflammation, West Nile virus, flaviviruses
Selected Publications
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Strange DP, Green R, Siemann DN, Gale M Jr, Verma S.
Immunoprofiles of human Sertoli cells infected with Zika virus reveals unique insights into host-pathogen crosstalk.
Scientific Reports
2018
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Lai C-Y, Strange DP, Wong TAS, Lehrer AT, Verma S.
Ebola virus glycoprotein induces an innate immune response in vivo via TLR4.
Frontiers in Microbiology
2017
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Siemann DN, Strange DP, Maharaj PN, Shi PY, Verma S.
Zika virus infects human Sertoli cells and modulates the integrity of the in vitro blood-testis barrier model.
Journal of Virology
2017
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Nelson J, Roe K, Orillo B, Shi PY, Verma S.
Combined treatment of adenosine nucleoside inhibitor NITD008 and histone deacetylase inhibitor vorinostat represents an immunotherapy strategy to ameliorate West Nile virus infection.
Antiviral Research
2015
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Kumar M, Roe K, Nerurkar PV, Orillo B, Thompson KS, Verma S, Nerurkar VR.
Reduced immune cell infiltration and increased pro-inflammatory mediators in the brain of Type 2 diabetic mouse model infected with West Nile virus.
Journal of Neuroinflammation
2014
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Roe K, Gibot S, Verma S.
Triggering receptor expressed on myeloid cells-1 (TREM-1): a new player in antiviral immunity?
Frontiers in Microbiology
2014
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Roe K, Orillo B, Verma S.
West Nile virus-induced cell adhesion molecules on human brain microvascular endothelial cells regulate leukocyte adhesion and modulate permeability of the in vitro blood-brain barrier model.
PLoS One
2014
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Kumar M, Roe K, Orillo B, Muruve DA, Nerurkar VR, Gale M, Verma S.
Inflammasome adaptor protein apoptosis-associated speck-like protein containing CARD (ASC) is critical for the immune response and survival in West Nile virus encephalitis.
Journal of Virology
2013
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Kumar M, Roe K, Nerurkar PV, Namekar M, Orillo B, Verma S, Nerurkar VR.
Impaired virus clearance, compromised immune response and increased mortality in Type 2 diabetic mice infected with West Nile virus.
PLoS One
2012
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Roe K, Kumar M, Lum S, Orillo B, Nerurkar VR, Verma S.
West Nile virus-induced disruption of the blood-brain barrier in mice is characterized by the degradation of the junctional complex proteins and increase in multiple matrix metalloproteinases.
Journal of General Virology
2012
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Verma S, Hoffmann FW, Kumar M, Huang Z, Roe K, Nguyen-Wu E, Hashimoto AS, Hoffmann PR.
Selenoprotein K knockout mice exhibit deficient calcium flux in immune cells and impaired immune responses.
Journal of Immunology
2011
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Verma S, Kumar M, Nerurkar VR.
Cyclooxygenase-2 inhibitor blocks the production of West Nile virus-induced neuroinflammatory markers in astrocytes.
Journal of General Virology
2011
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Kumar M, Verma S, Nerurkar VR.
Pro-inflammatory cytokines derived from West Nile virus (WNV)-infected SK-N-SH cells mediate neuroinflammatory markers and neuronal death.
Journal of Neuroinflammation
2010
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Verma S, Kumar M, Gurjav U, Lum S, Nerurkar VR.
Reversal of West Nile virus-induced blood-brain barrier disruption and tight junction proteins degradation by matrix metalloproteinases inhibitor.
Virology
2010
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Verma S, Lo Y, Chapagain M, Lum S, Kumar M, Gurjav U, Luo H, Nakatsuka A, Nerurkar VR.
West Nile virus infection modulates human brain microvascular endothelial cells tight junction proteins and cell adhesion molecules: Transmigration across the in vitro blood-brain barrier.
Virology
2009
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Verma S, Molina Y, Lo YY, Cropp B, Nakano C, Yanagihara R, Nerurkar VR.
In vitro effects of selenium deficiency on West Nile virus replication and cytopathogenicity.
Virology Journal
2008
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Grants
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Grant No / Title: R21AI129465 / Under Attack: Modulation of the Blood-Testes Barrier by Zika Virus
Status / Agency: Awarded / NIH/NIAID
Start Date / End Date: 08 November 2016 / 31 October 2018
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