Publication Detail
An evaluation of statistical methods for DNA methylation microarray data analysis.
Li D, Xie Z, Pape ML, Dye T.
Citation
Li D, Xie Z, Pape ML, Dye T. (2015) An evaluation of statistical methods for DNA methylation microarray data analysis. BMC Bioinformatics 16:217.
Abstract
For DNA methylation studies with small sample size, the bump hunting method and the empirical Bayes method are recommended when DNA methylation levels across CpG loci are independent, while only the bump hunting method is recommended when DNA methylation levels are correlated across CpG loci. All methods are acceptable for medium or large sample sizes.
| Link: | http://www.ncbi.nlm.nih.gov/pubmed/26156501 |
| PMID: | 26156501 |
| PMCID: | PMC4497424 |