Order By : Year | Journal | Author

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David A. Relman, M.D.

• Bik EM, Costello EK, Switzer AD, Callahan BJ, Holmes SP, Wells RS, Carlin KP, Jensen ED, Venn-Watson S, Relman DA. (2016) Marine mammals harbor unique microbiotas shaped by and yet distinct from the sea. Nature Communications 7:10516. more details…

• Inglesby TV, Relman DA. (2016) How likely is it that biological agents will be used deliberately to cause widespread harm? Policymakers and scientists need to take seriously the possibility that potential pandemic pathogens will be misused. EMBO Reports 17(2):127-130. more details…

• DiGiulio DB, Callahan BJ, McMurdie PJ, Costello EK, Lyell DJ, Robaczewska A, Sun CL, Goltsman DS, Wong RJ, Shaw G, Stevenson DK, Holmes SP, Relman DA. (2015) Temporal and spatial variation of the human microbiota during pregnancy. Proceedings of the National Academy of Sciences U S A 112(35):11060-11065. more details…

• Duprex WP, Fouchier RA, Imperiale MJ, Lipsitch M, Relman DA. (2015) Gain-of-function experiments: time for a real debate. Nature Reviews of Microbiology 13(1):58-64. more details…

• Hoy YE, Bik EM, Lawley TD, Holmes SP, Monack DM, Theriot JA, Relman DA. (2015) Variation in taxonomic composition of the fecal microbiota in an inbred mouse strain across individuals and time. PLoS One 10(11):e0142825. more details…

• Palmer MJ, Fukuyama F, Relman DA. (2015) SCIENCE GOVERNANCE. A more systematic approach to biological risk. Science 350(6267):1471-1473. more details…

• Relman DA. (2015) The human microbiome and the future practice of medicine. Journal of the American Medical Association 314(11):1127-1128. more details…

• Relman DA. (2015) Actionable sequence data on infectious diseases in the clinical workplace. Clinical Chemistry 61(1):38-40. more details…

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Diane E. Griffin, M.D., Ph.D.

• Fiebelkorn AP, Coleman LA, Belongia EA, Freeman SK, York D, Bi D, Kulkarni A, Audet S, Mercader S, McGrew M, Hickman CJ, Bellini WJ, Shivakoti R, Griffin DE, Beeler J. (2016) Measles virus neutralizing antibody response, cell-mediated immunity, and immunoglobulin G antibody avidity before and after receipt of a third dose of measles, mumps, and rubella vaccine in young adults. Journal of Infectious Diseases 213(7):1115-1123. more details…

• Ludlow M, Kortekaas J, Herden C, Hoffmann B, Tappe D, Trebst C, Griffin DE, Brindle HE, Solomon T, Brown AS, van Riel D, Wolthers KC, Pajkrt D, Wohlsein P, Martina BE, Baumgartner W, Verjans GM, Osterhaus AD. (2016) Neurotropic virus infections as the cause of immediate and delayed neuropathology. Acta Neuropathologica 131(2):159-184. more details…

• Kulcsar KA, Baxter VK, Abraham R, Nelson A, Griffin DE. (2015) Distinct immune responses in resistant and susceptible strains of mice during neurovirulent alphavirus encephalomyelitis. Journal of Virology 89(16):8280-8291. more details…

• Potter MC, Baxter VK, Mathey RW, Alt J, Rojas C, Griffin DE, Slusher BS. (2015) Neurological sequelae induced by alphavirus infection of the CNS are attenuated by treatment with the glutamine antagonist 6-diazo-5-oxo-l-norleucine. Journal of Neurovirology 21(2):159-173. more details…

• Schultz KL, Vernon PS, Griffin DE. (2015) Differentiation of neurons restricts arbovirus replication and increases expression of the alpha isoform of IRF-7. Journal of Virology 89(1):48-60. more details…

• Shivakoti R, Hauer D, Adams RJ, Lin WH, Duprex WP, de Swart RL, Griffin DE. (2015) Limited in vivo production of type I or type III interferon after infection of macaques with vaccine or wild-type strains of measles virus. Journal of Interferon and Cytokine Research 35(4):292-301. more details…

• Bogerd HP, Skalsky RL, Kennedy EM, Furuse Y, Whisnant AW, Flores O, Schultz KL, Putnam N, Barrows NJ, Sherry B, Scholle F, Garcia-Blanco MA, Griffin DE, Cullen BR. (2014) Replication of many human viruses is refractory to inhibition by endogenous cellular microRNAs. Journal of Virology 88(14):8065-8076. more details…

• Chiu YL, Shan L, Huang H, Haupt C, Bessell C, Canaday DH, Zhang H, Ho YC, Powell JD, Oelke M, Margolick JB, Blankson JN, Griffin DE, Schneck JP. (2014) Sprouty-2 regulates HIV-specific T cell polyfunctionality. Journal of Clinical Investigation 124(1):198-208. more details…

• Griffin DE. (2014) Measles virus and the nervous system. Handbook of Clinical Neurology 123:577-590. more details…

• Kulcsar KA, Baxter VK, Greene IP, Griffin DE. (2014) Interleukin 10 modulation of pathogenic Th17 cells during fatal alphavirus encephalomyelitis. Proceedings of the National Academy of Sciences U S A 111(45):16053-16058. more details…

• Lin WH, Pan CH, Adams RJ, Laube BL, Griffin DE. (2014) Vaccine-induced measles virus-specific T cells do not prevent infection or disease but facilitate subsequent clearance of viral RNA. MBio 5(2):e01047. more details…

• Lee EY, Schultz KL, Griffin DE. (2013) Mice deficient in interferon-gamma or interferon-gamma receptor 1 have distinct inflammatory responses to acute viral encephalomyelitis. PLoS One 8(10):e76412. more details…

• Lin WH, Vilalta A, Adams RJ, Rolland A, Sullivan SM, Griffin DE. (2013) Vaxfectin adjuvant improves antibody responses of juvenile rhesus macaques to a DNA vaccine encoding the measles virus hemagglutinin and fusion proteins. Journal of Virology 87(12):6560-6568. more details…

• Metcalf TU, Baxter VK, Nilaratanakul V, Griffin DE. (2013) Recruitment and retention of B cells in the central nervous system in response to alphavirus encephalomyelitis. Journal of Virology 87(5):2420-2429. more details…

• Polack FP, Lydy SL, Lee SH, Rota PA, Bellini WJ, Adams RJ, Robinson HL, Griffin DE. (2013) Poor immune responses of newborn rhesus macaques to measles virus DNA vaccines expressing the hemagglutinin and fusion glycoproteins. Clinical and Vaccine Immunology 20(2):205-210. more details…

• Shivakoti R, Siwek M, Hauer D, Schultz KL, Griffin DE. (2013) Induction of dendritic cell production of type I and type III interferons by wild-type and vaccine strains of measles virus: role of defective interfering RNAs. Journal of Virology 87(14):7816-7827. more details…

• Snyder JE, Kulcsar KA, Schultz KL, Riley CP, Neary JT, Marr S, Jose J, Griffin DE, Kuhn RJ. (2013) Functional characterization of the alphavirus TF protein. Journal of Virology 87(15):8511-8523. more details…

• Griffin DE, Lin WH, Pan CH. (2012) Measles virus, immune control and persistence. FEMS Microbiology Review 36(3):649-662. more details…

• Lin WH, Kouyos RD, Adams RJ, Grenfell BT, Griffin DE. (2012) Prolonged persistence of measles virus RNA is characteristic of primary infection dynamics. Proceedings of the National Academy of Sciences U S A 109(37):14989-14994. more details…

• Moss WJ, Griffin DE. (2012) Measles. Lancet 379(9811):153-164. more details…

• Okamoto Y, Vricella LA, Moss WJ, Griffin DE. (2012) Immature CD4+CD8+ thymocytes are preferentially infected by measles virus in human thymic organ cultures. PLoS One 7(9):e45999. more details…

• von Messling VA, Griffin DE. (2012) How respiratory viruses overcome mucosal defenses and exploit the unique environment of the respiratory tract. Current Opinions in Virology 2(3):221-224. more details…

• Griffin DE, Metcalf T. (2011) Clearance of virus infection from the CNS. Current Opinions in Virology 1(3):216-221. more details…

• Griffin DE. (2011) Viral encephalomyelitis. PLoS Pathogens 7(3):e1002004. more details…

• Lin WH, Griffin DE, Rota PA, Papania M, Cape SP, Bennett D, Quinn B, Sievers RE, Shermer C, Powell K, Adams RJ, Godin S, Winston S. (2011) Successful respiratory immunization with dry powder live-attenuated measles virus vaccine in rhesus macaques. Proceedings of the National Academy of Sciences USA 108(7):2987-2992. more details…

• Metcalf TU, Griffin DE. (2011) Alphavirus-induced encephalomyelitis: antibody-secreting cells and viral clearance from the nervous system. Journal of Virology more details…

• Moss WJ, Griffin DE. (2011) Measles. Lancet more details…

• Bergen MJ, Pan CH, Greer CE, Legg HS, Polo JM, Griffin DE. (2010) Comparison of the immune responses induced by chimeric alphavirus-vectored and formalin-inactivated alum-precipitated measles vaccines in mice. PLoS One 5(4):e10297. more details…

• Griffin DE. (2010) Measles virus-induced suppression of immune responses. Immunology Review 236:176-189. more details…

• Griffin DE. (2010) Recovery from viral encephalomyelitis: immune-mediated noncytolytic virus clearance from neurons. Immunological Research 47(1-3):123-133. more details…

• Griffin DE. (2010) Emergence and re-emergence of viral diseases of the central nervous system. Progress in Neurobiology 91(2):95-101. more details…

• Ndhlovu ZM, Oelke M, Schneck JP, Griffin DE. (2010) Dynamic regulation of functionally distinct virus-specific T cells. Proceedings of the National Academy of Sciences USA 107(8):3669-3674. more details…

• Pan CH, Greer CE, Hauer D, Legg HS, Lee EY, Bergen MJ, Lau B, Adams RJ, Polo JM, Griffin DE. (2010) A chimeric alphavirus replicon particle vaccine expressing the hemagglutinin and fusion proteins protects juvenile and infant rhesus macaques from measles. Journal of Virology 84(8):3798-3807. more details…

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Gwong-Jen J. Chang, Ph.D.

• Welch RJ, Chang GJ, Litwin CM. (2014) Comparison of a commercial dengue IgM capture ELISA with dengue antigen focus reduction microneutralization test and the centers for disease control dengue IgM capture-ELISA. Journal of Virological Methods 195:247-249. more details…

• Lin HE, Tsai WY, Liu IJ, Li PC, Liao MY, Tsai JJ, Wu YC, Lai CY, Lu CH, Huang JH, Chang GJ, Wu HC, Wang WK. (2012) Analysis of epitopes on dengue virus envelope protein recognized by monoclonal antibodies and polyclonal human sera by a high throughput assay. PLoS Neglected Tropical Diseases 6(1):e1447. more details…

• Calvert AE, Kalantarov GF, Chang GJ, Trakht I, Blair CD, Roehrig JT. (2011) Human monoclonal antibodies to West Nile virus identify epitopes on the prM protein. Virology 410(1):30-37. more details…

• Kilpatrick AM, Dupuis AP, Chang GJ, Kramer LD. (2010) DNA vaccination of American robins (Turdus migratorius) against West Nile virus. Vector Borne and Zoonotic Diseases 10(4):377-380. more details…

• Crill WD, Hughes HR, Delorey MJ, Chang GJ. (2009) Humoral immune responses of dengue fever patients using epitope-specific serotype-2 virus-like particle antigens. PLoS One 4(4):e4991. more details…

• Das S, Pingle MR, MuÃ?±oz-JordÃ?¡n J, Rundell MS, Rondini S, Granger K, Chang GJ, Kelly E, Spier EG, Larone D, Spitzer E, Barany F, Golightly LM. (2008) Detection and serotyping of dengue virus in serum samples by multiplex reverse transcriptase PCR-ligase detection reaction assay. Journal of Clinical Microbiology 46(10):3276-3284. more details…

• Hsieh SC, Liu IJ, King CC, Chang GJ, Wang WK. (2008) A strong endoplasmic reticulum retention signal in the stem-anchor region of envelope glycoprotein of dengue virus type 2 affects the production of virus-like particles. Virology 374(2):338-350. more details…

• Lai CY, Tsai WY, Lin SR, Kao CL, Hu HP, King CC, Wu HC, Chang GJ, Wang WK. (2008) Antibodies to envelope glycoprotein of dengue virus during the natural course of infection are predominantly cross-reactive and recognize epitopes containing highly conserved residues at the fusion loop of domain II. Journal of Virology 82(13):6631-6643. more details…

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Katherine E. Conant, M.D.

• Conant K, Lonskaya I, Szklarczyk A, Krall C, Steiner J, Maguire-Zeiss K, Lim ST. (2011) Methamphetamine-associated cleavage of the synaptic adhesion molecule intercellular adhesion molecule-5. Journal of Neurochemistry 118(4):521-532. more details…

• Ragin AB, Wu Y, Ochs R, Du H, Epstein LG, Conant K, McArthur JC. (2011) Marked relationship between matrix metalloproteinase 7 and brain atrophy in HIV infection. Journal of Neurovirology 17(2):153-158. more details…

• Conant K, Lonskaya I, Szklarczyk A, Krall C, Steiner J, Maguire-Zeiss K, Lim ST. (2010) Methamphetamine-associated cleavage of the synaptic adhesion molecule intercellular adhesion molecule-5. Journal of Neurochemistry 118(4):521-532. more details…

• Lentz MR, Degaonkar M, Mohamed MA, Kim H, Conant K, Halpern EF, Sacktor N, Barker PB, Pomper MG. (2010) Exploring the relationship of macrophage colony-stimulating factor levels on neuroaxonal metabolism and cognition during chronic human immunodeficiency virus infection. Journal of Neurovirology 16(5):368-376. more details…

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Mariano A. Garcia-Blanco, M.D., Ph.D.

• Anwar A, Hosoya T, Leong KM, Onogi H, Okuno Y, Hiramatsu T, Koyama H, Suzuki M, Hagiwara M, Garcia-Blanco MA. (2011) The kinase inhibitor SFV785 dislocates dengue virus envelope protein from the replication complex and blocks virus assembly. PLoS One 6(8):e23246. more details…

• Armstrong AJ, Marengo MS, Oltean S, Kemeny G, Bitting RL, Turnbull JD, Herold CI, Marcom PK, George DJ, Garcia-Blanco MA. (2011) Circulating tumor cells from patients with advanced prostate and breast cancer display both epithelial and mesenchymal markers. Molecular Cancer Research 9(8):997-1007. more details…

• Miller HB, Robinson TJ, Gordân R, Hartemink AJ, Garcia-Blanco MA. (2011) Identification of Tat-SF1 cellular targets by exon array analysis reveals dual roles in transcription and splicing. RNA 17(4):665-674. more details…

• Ward AM, Bidet K, Yinglin A, Ler SG, Hogue K, Blackstock W, Gunaratne J, Garcia-Blanco MA. (2011) Quantitative mass spectrometry of DENV-2 RNA-interacting proteins reveals that the DEAD-box RNA helicase DDX6 binds the DB1 and DB2 3’ UTR structures. RNA Biology 8(6):1173-1186. more details…

• Zhang X, Nicholls PJ, Laje G, Sotnikova TD, Gainetdinov RR, Albert PR, Rajkowska G, Stockmeier CA, Speer MC, Steffens DC, Austin MC, McMahon FJ, Krishnan KR, Garcia-Blanco MA, Caron MG. (2011) A functional alternative splicing mutation in human tryptophan hydroxylase-2. Molecular Psychiatry 16(12):1169-1176 more details…

• Barrows NJ, Le Sommer C, Garcia-Blanco MA, Pearson JL. (2010) Factors affecting reproducibility between genome-scale siRNA-based screens. Journal of Biomolecular Screening 15(7):735-747. more details…

• Evsyukova I, Somarelli JA, Gregory SG, Garcia-Blanco MA. (2010) Alternative splicing in multiple sclerosis and other autoimmune diseases. RNA Biology 7(4):462-473. more details…

• Robinson TJ, Dinan MA, Dewhirst M, Garcia-Blanco MA, Pearson JL. (2010) SplicerAV: a tool for mining microarray expression data for changes in RNA processing. BMC Bioinformatics 11:108. more details…

• Rodriguez-Martin T, Anthony K, Garcia-Blanco MA, Mansfield SG, Anderton BH, Gallo JM. (2009) Correction of tau mis-splicing caused by FTDP-17 MAPT mutations by spliceosome-mediated RNA trans-splicing. Human Molecular Genetics 18(17):3266-3273. more details…

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Richard J. Kuhn, Ph.D.

• Grabowski JM, Perera R, Roumani AM, Hedrick VE, Inerowicz HD, Hill CA, Kuhn RJ. (2016) Changes in the proteome of Langat-infected Ixodes scapularis ISE6 cells: Metabolic pathways associated with flavivirus infection. PLoS Neglected Tropical Diseases 10(2):e0004180. more details…

• Gulia-Nuss M, et al. (2016) Genomic insights into the Ixodes scapularis tick vector of Lyme disease. Nature Communications 7:10507. more details…

• Akey DL, Brown WC, Jose J, Kuhn RJ, Smith JL. (2015) Structure-guided insights on the role of NS1 in flavivirus infection. Bioessays 37(5):489-494. more details…

• D’Aquila T, Sirohi D, Grabowski JM, Hedrick VE, Paul LN, Greenberg AS, Kuhn RJ, Buhman KK. (2015) Characterization of the proteome of cytoplasmic lipid droplets in mouse enterocytes after a dietary fat challenge. PLoS One 10(5):e0126823. more details…

• Jose J, Tang J, Taylor AB, Baker TS, Kuhn RJ. (2015) Fluorescent protein-tagged Sindbis virus E2 glycoprotein allows single particle analysis of virus budding from live cells. Viruses 7(12):6182-6199. more details…

• Kuhn RJ, Dowd KA, Beth Post C, Pierson TC. (2015) Shake, rattle, and roll: Impact of the dynamics of flavivirus particles on their interactions with the host. Virology 479-480508-17. more details…

• Liu Y, Sheng J, Fokine A, Meng G, Shin WH, Long F, Kuhn RJ, Kihara D, Rossmann MG. (2015) Structure and inhibition of EV-D68, a virus that causes respiratory illness in children. Science 347(6217):71-74. more details…

• Yan R, Edwards TJ, Pankratz LM, Kuhn RJ, Lanman JK, Liu J, Jiang W. (2015) A fast cross-validation method for alignment of electron tomography images based on Beer-Lambert law. Journal of Structural Biology 192(2):297-306. more details…

• Yan R, Edwards TJ, Pankratz LM, Kuhn RJ, Lanman JK, Liu J, Jiang W. (2015) Simultaneous determination of sample thickness, tilt, and electron mean free path using tomographic tilt images based on Beer-Lambert law. Journal of Structural Biology 192(2):287-296. more details…

• Zhang X, Sheng J, Austin SK, Hoornweg TE, Smit JM, Kuhn RJ, Diamond MS, Rossmann MG. (2015) Structure of acidic pH dengue virus showing the fusogenic glycoprotein trimers. Journal of Virology 89(1):743-750. more details…

• Aggarwal M, Dhindwal S, Kumar P, Kuhn RJ, Tomar S. (2014) trans-Protease activity and structural insights into the active form of the alphavirus capsid protease. Journal of Virology 88(21):12242-12253. more details…

• Akey DL, Brown WC, Dutta S, Konwerski J, Jose J, Jurkiw TJ, DelProposto J, Ogata CM, Skiniotis G, Kuhn RJ, Smith JL. (2014) Flavivirus NS1 structures reveal surfaces for associations with membranes and the immune system. Science 343(6173):881-885. more details…

• Apte-Sengupta S, Sirohi D, Kuhn RJ. (2014) Coupling of replication and assembly in flaviviruses. Current Opinion in Virology 9:134-142. more details…

• Dowd KA, Mukherjee S, Kuhn RJ, Pierson TC. (2014) Combined effects of the structural heterogeneity and dynamics of flaviviruses on antibody recognition. Journal of Virology 88(20):11726-11737. more details…

• Junjhon J, Pennington JG, Edwards TJ, Perera R, Lanman J, Kuhn RJ. (2014) Ultrastructural characterization and three-dimensional architecture of replication sites in dengue virus-infected mosquito cells. Journal of Virology more details…

• Plevka P, Lim PY, Perera R, Cardosa J, Suksatu A, Kuhn RJ, Rossmann MG. (2014) Neutralizing antibodies can initiate genome release from human enterovirus 71. Proceedings of the National Academy of Sciences USA 111(6):2134-2139. more details…

• Catanese MT, Uryu K, Kopp M, Edwards TJ, Andrus L, Rice WJ, Silvestry M, Kuhn RJ, Rice CM. (2013) Ultrastructural analysis of hepatitis C virus particles. Proceedings of the National Academy of Sciences U S A 110(23):9505-9510. more details…

• Dai HS, Liu Z, Jiang W, Kuhn RJ. (2013) Directed evolution of a virus exclusively utilizing human epidermal growth factor receptor as the entry receptor. Journal of Virology 87(20):11231-11243. more details…

• Keating JA, Bhattacharya D, Lim PY, Falk S, Weisblum B, Bernard KA, Sharma M, Kuhn RJ, Striker R. (2013) West Nile virus methyltransferase domain interacts with protein kinase G. Virology Journal 10242. more details…

• Plevka P, Perera R, Yap ML, Cardosa J, Kuhn RJ, Rossmann MG. (2013) Structure of human enterovirus 71 in complex with a capsid-binding inhibitor. Proceedings of the National Academy of Sciences U S A more details…

• Zhang W, Kaufmann B, Chipman PR, Kuhn RJ, Rossmann MG. (2013) Membrane curvature in flaviviruses. Journal of Structural Biology 183(1):86-94. more details…

• Zhang X, Sheng J, Plevka P, Kuhn RJ, Diamond MS, Rossmann MG. (2013) Dengue structure differs at the temperatures of its human and mosquito hosts. Proceedings of the National Academy of Sciences USA 110(17):6795-6799. more details…

• Battisti AJ, Yoder JD, Plevka P, Winkler DC, Prasad VM, Kuhn RJ, Frey TK, Steven AC, Rossmann MG. (2012) Cryo-electron tomography of rubella virus. Journal of Virology 86(20):11078-11085. more details…

• Jose J, Przybyla L, Edwards TJ, Perera R, Burgner JW, Kuhn RJ. (2012) Interactions of the cytoplasmic domain of Sindbis virus E2 with nucleocapsid cores promote alphavirus budding. Journal of Virology 86(5):2585-2599. more details…

• Perera R, Riley C, Isaac G, Hopf-Jannasch AS, Moore RJ, Weitz KW, Pasa-Tolic L, Metz TO, Adamec J, Kuhn RJ. (2012) Dengue virus infection perturbs lipid homeostasis in infected mosquito cells. PLoS Pathogens 8(3):e1002584. more details…

• Pierson TC, Kuhn RJ. (2012) Capturing a virus while it catches its breath. Structure 20(2):200-202. more details…

• Plevka P, Perera R, Cardosa J, Kuhn RJ, Rossmann MG. (2012) Structure determination of enterovirus 71. Acta Crystallogr D Biol Crystallogr 68(Pt 9):1217-1222. more details…

• Plevka P, Perera R, Cardosa J, Kuhn RJ, Rossmann MG. (2012) Crystal structure of human enterovirus 71. Science 336(6086):1274. more details…

• Snyder JE, Berrios CJ, Edwards TJ, Jose J, Perera R, Kuhn RJ. (2012) Probing the early temporal and spatial interaction of the Sindbis virus capsid and E2 proteins with reverse genetics. Journal of Virology 86(22):12372-12383. more details…

• Aggarwal M, Dhindwal S, Pratap S, Kuhn RJ, Kumar P, Tomar S. (2011) Crystallization, high-resolution data collection and preliminary crystallographic analysis of Aura virus capsid protease and its complex with dioxane. Acta Crystallographica. Sect F, Structural Biology and Crystallization Communications 67(Pt 11):1394-1398. more details…

• Gualtieri EJ, Guo F, Kissick DJ, Jose J, Kuhn RJ, Jiang W, Simpson GJ. (2011) Detection of membrane protein two-dimensional crystals in living cells. Biophysics Journal 100(1):207-214. more details…

• Khadka S, Vangeloff AD, Zhang C, Siddavatam P, Heaton NS, Wang L, Sengupta R, Sahasrabudhe S, Randall G, Gribskov M, Kuhn RJ, Perera R, LaCount DJ. (2011) A physical interaction network of dengue virus and human proteins. Molecular and Cellular Proteomics 10(12):M111.012187. more details…

• Mayhoub AS, Khaliq M, Botting C, Li Z, Kuhn RJ, Cushman M. (2011) An investigation of phenylthiazole antiflaviviral agents. Bioorganic and Medicinal Chemistry 19(12):3845-3854. more details…

• Mayhoub AS, Khaliq M, Kuhn RJ, Cushman M. (2011) Design, synthesis, and biological evaluation of thiazoles targeting flavivirus envelope proteins. Journal of Medicinal Chemistry 54(6):1704-1714. more details…

• Plevka P, Battisti AJ, Junjhon J, Winkler DC, Holdaway HA, Keelapang P, Sittisombut N, Kuhn RJ, Steven AC, Rossmann MG. (2011) Maturation of flaviviruses starts from one or more icosahedrally independent nucleation centres. EMBO Reports 12(6):602-606. more details…

• Snyder JE, Azizgolshani O, Wu B, He Y, Lee AC, Jose J, Suter DM, Knobler CM, Gelbart WM, Kuhn RJ. (2011) Rescue of infectious particles from preassembled alphavirus nucleocapsid cores. Journal of Virology 85(12):5773-5781. more details…

• Tang J, Jose J, Chipman P, Zhang W, Kuhn RJ, Baker TS. (2011) Molecular links between the E2 envelope glycoprotein and nucleocapsid core in Sindbis virus. Journal of Molecular Biology 414(3):442-459. more details…

• Tomar S, Narwal M, Harms E, Smith JL, Kuhn RJ. (2011) Heterologous production, purification and characterization of enzymatically active Sindbis virus nonstructural protein nsP1. Protein Expression and Purification 79(2):277-284. more details…

• Heaton NS, Perera R, Berger KL, Khadka S, Lacount DJ, Kuhn RJ, Randall G. (2010) Dengue virus nonstructural protein 3 redistributes fatty acid synthase to sites of viral replication and increases cellular fatty acid synthesis. Proceedings of the National Academy of Sciences USA 107(40):17345-17350. more details…

• Junjhon J, Edwards TJ, Utaipat U, Bowman VD, Holdaway HA, Zhang W, Keelapang P, Puttikhunt C, Perera R, Chipman PR, Kasinrerk W, Malasit P, Kuhn RJ, Sittisombut N. (2010) Influence of pr-M cleavage on the heterogeneity of extracellular dengue virus particles. Journal of Virology 84(16):8353-8358. more details…

• Kaufmann B, Plevka P, Kuhn RJ, Rossmann MG. (2010) Crystallization and preliminary X-ray diffraction analysis of West Nile virus. Acta Crystallographica Section F: Structural Biology and Crystallization Communications 66(Pt 5):558-562. more details…

• Kaufmann B, Vogt MR, Goudsmit J, Holdaway HA, Aksyuk AA, Chipman PR, Kuhn RJ, Diamond MS, Rossmann MG. (2010) Neutralization of West Nile virus by cross-linking of its surface proteins with Fab fragments of the human monoclonal antibody CR4354. Proceedings of the National Academy of Sciences USA 107(44):18950-18955. more details…

• Li L, Jose J, Xiang Y, Kuhn RJ, Rossmann MG. (2010) Structural changes of envelope proteins during alphavirus fusion. Nature 468(7324):705-708. more details…

• Yu IM, Holdaway HA, Chipman PR, Kuhn RJ, Rossmann MG, Chen J. (2009) Association of the pr peptides with dengue virus at acidic pH blocks membrane fusion. Journal of Virology 83(23):12101-12107. more details…

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William C. Nierman, Ph.D.

• Krishnan K, Ren Z, Losada L, Nierman WC, Lu LJ, Askew DS. (2014) Polysome profiling reveals broad translatome remodeling during endoplasmic reticulum (ER) stress in the pathogenic fungus Aspergillus fumigatus. BMC Genomics 15(1):159. more details…

• Losada L, Pakala SB, Fedorova ND, Joardar V, Shabalina SA, Hostetler J, Pakala SM, Zafar N, Thomas E, Rodriguez-Carres M, Dean R, Vilgalys R, Nierman WC, Cubeta MA. (2014) Mobile elements and mitochondrial genome expansion in the soil fungus and potato pathogen Rhizoctonia solani AG-3. FEMS Microbiology Letters more details…

• Gravelat FN, Beauvais A, Liu H, Lee MJ, Snarr BD, Chen D, Xu W, Kravtsov I, Hoareau CM, Vanier G, Urb M, Campoli P, Al Abdallah Q, Lehoux M, Chabot JC, Ouimet MC, Baptista SD, Fritz JH, Nierman WC, LatgÃ?© JP, Mitchell AP, Filler SG, Fontaine T, Sheppard DC. (2013) Aspergillus galactosaminogalactan mediates adherence to host constituents and conceals hyphal Ã?²-glucan from the immune system. PLoS Pathogens 9(8):e1003575. more details…

• Skamnaki VT, Peumans WJ, Kantsadi AL, Cubeta MA, Plas K, Pakala S, Zographos SE, Smagghe G, Nierman WC, Van Damme EJ, Leonidas DD. (2013) Structural analysis of the Rhizoctonia solani agglutinin reveals a domain-swapping dimeric assembly. FEBS Journal more details…

• Varga JJ, Losada L, Zelazny AM, Kim M, McCorrison J, Brinkac L, Sampaio EP, Greenberg DE, Singh I, Heiner C, Ashby M, Nierman WC, Holland SM, Goldberg JB. (2013) Draft genome sequences of Burkholderia cenocepacia ET12 lineage strains K56-2 and BC7. Genome Announcements 1(5): more details…

• Vipond J, Kane J, Hatch G, McCorrison J, Nierman WC, Losada L. (2013) Sequence Determination of Burkholderia pseudomallei Strain NCTC 13392 Colony Morphology Variants. Genome Announcements 1(6): more details…

• Thomas E, Pakala S, Fedorova ND, Nierman WC, Cubeta MA. (2012) Triallelic SNP-mediated genotyping of regenerated protoplasts of the heterokaryotic fungus Rhizoctonia solani. Journal of Biotechnology more details…

• Zhang D, Lax AR, Henrissat B, Coutinho P, Katiya N, Nierman WC, Fedorova N. (2012) Carbohydrate-active enzymes revealed in Coptotermes formosanus (Isoptera: Rhinotermitidae) transcriptome. Insect Molecular Biology more details…

• Chaturvedi V, Nierman WC. (2011) Cryptococcus gattii comparative genomics and transcriptomics: A NIH/NIAID white paper. Mycopathologia more details…

• Feng X, Krishnan K, Richie DL, Aimanianda V, Hartl L, Grahl N, Powers-Fletcher MV, Zhang M, Fuller KK, Nierman WC, Lu LJ, Latgé JP, Woollett L, Newman SL, Cramer RA, Rhodes JC, Askew DS. (2011) HacA-independent functions of the ER stress sensor IreA synergize with the canonical UPR to influence virulence traits in Aspergillus fumigatus. PLoS Pathogens 7(10):e1002330. more details…

• Guo B, Fedorova ND, Chen X, Wan CH, Wang W, Nierman WC, Bhatnagar D, Yu J. (2011) Gene expression profiling and identification of resistance genes to Aspergillus flavus infection in peanut through EST and microarray strategies. Toxins (Basel) 3(7):737-753. more details…

• Huntley S, Hamann N, Wegener-Feldbrügge S, Treuner-Lange A, Kube M, Reinhardt R, Klages S, Müller R, Ronning CM, Nierman WC, Søgaard-Andersen L. (2011) Comparative genomic analysis of fruiting body formation in Myxococcales. Molecular Biology and Evolution 28(2):1083-1097. more details…

• Kang Y, Norris MH, Zarzycki-Siek J, Nierman WC, Donachie SP, Hoang TT. (2011) Transcript amplification from single bacterium for transcriptome analysis. Genome Research 21(6):925-935. more details…

• Losada L, Varga JJ, Hostetler J, Radune D, Kim M, Durkin S, Schneewind O, Nierman WC. (2011) Genome sequencing and analysis of Yersina pestis KIM D27, an avirulent strain exempt from select agent regulation. PLoS One 6(4):e19054. more details…

• Morton CO, Varga JJ, Hornbach A, Mezger M, Sennefelder H, Kneitz S, Kurzai O, Krappmann S, Einsele H, Nierman WC, Rogers TR, Loeffler J. (2011) The temporal dynamics of differential gene expression in Aspergillus fumigatus interacting with human immature dendritic cells in vitro. PLoS One 6(1):e16016. more details…

• Sugui JA, Losada L, Wang W, Varga J, Ngamskulrungroj P, Abu-Asab M, Chang YC, O’Gorman CM, Wickes BL, Nierman WC, Dyer PS, Kwon-Chung KJ. (2011) Identification and characterization of an Aspergillus fumigatus “supermater” pair. mBio 2(6): more details…

• Yu J, Fedorova ND, Montalbano BG, Bhatnagar D, Cleveland TE, Bennett JW, Nierman WC. (2011) Tight control of mycotoxin biosynthesis gene expression in Aspergillus flavus by temperature as revealed by RNA-Seq. FEMS Microbiology Letters more details…

• Ben-Ami R, Varga V, Lewis RE, May GS, Nierman WC, Kontoyiannis DP. (2010) Characterization of a 5-azacytidine-induced developmental Aspergillus fumigatus variant. Virulence 1(3):164-173. more details…

• Liu H, Gravelat FN, Chiang LY, Chen D, Vanier G, Ejzykowicz DE, Ibrahim AS, Nierman WC, Sheppard DC, Filler SG. (2010) Aspergillus fumigatus AcuM regulates both iron acquisition and gluconeogenesis. Molecular Microbiology 78(4):1038-1054. more details…

• Losada L, Ronning CM, DeShazer D, Woods D, Fedorova N, Kim HS, Shabalina SA, Pearson TR, Brinkac L, Tan P, Nandi T, Crabtree J, Badger J, Beckstrom-Sternberg S, Saqib M, Schutzer SE, Keim P, Nierman WC. (2010) Continuing evolution of Burkholderia mallei through genome reduction and large-scale rearrangements. Genome Biology and Evolution 22:102-116. more details…

• Medema MH, Trefzer A, Kovalchuk A, van den Berg M, Müller U, Heijne W, Wu L, Alam MT, Ronning CM, Nierman WC, Bovenberg RA, Breitling R, Takano E. (2010) The sequence of a 1.8-mb bacterial linear plasmid reveals a rich evolutionary reservoir of secondary metabolic pathways. Genome Biology and Evolution 2:212-224. more details…

• Nandi T, Ong C, Singh AP, Boddey J, Atkins T, Sarkar-Tyson M, Essex-Lopresti AE, Chua HH, Pearson T, Kreisberg JF, Nilsson C, Ariyaratne P, Ronning C, Losada L, Ruan Y, Sung WK, Woods D, Titball RW, Beacham I, Peak I, Keim P, Nierman WC, Tan P. (2010) A genomic survey of positive selection in Burkholderia pseudomallei provides insights into the evolution of accidental virulence. PLoS Pathogens 6(4):e1000845. more details…

• Ronning CM, Losada L, Brinkac L, Inman J, Ulrich RL, Schell M, Nierman WC, Deshazer D. (2010) Genetic and phenotypic diversity in Burkholderia: contributions by prophage and phage-like elements. BMC Microbiology 10:202. more details…

• Song H, Hwang J, Yi H, Ulrich RL, Yu Y, Nierman WC, Kim HS. (2010) The early stage of bacterial genome-reductive evolution in the host. PLoS Pathogens 6(5):e1000922. more details…