William C. Nierman, Ph.D.
Infectious Diseases Investigator J. Craig Venter Institute Professor Department of Biochemistry and Molecular Biology George Washington University School of Medicine, Washington, DC
Phone: (301) 795-7559
Office:
Email: wnierman [at] jcvi.org
External Homepage
Selected Publications
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Krishnan K, Ren Z, Losada L, Nierman WC, Lu LJ, Askew DS.
Polysome profiling reveals broad translatome remodeling during endoplasmic reticulum (ER) stress in the pathogenic fungus Aspergillus fumigatus.
BMC Genomics
2014
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Losada L, Pakala SB, Fedorova ND, Joardar V, Shabalina SA, Hostetler J, Pakala SM, Zafar N, Thomas E, Rodriguez-Carres M, Dean R, Vilgalys R, Nierman WC, Cubeta MA.
Mobile elements and mitochondrial genome expansion in the soil fungus and potato pathogen Rhizoctonia solani AG-3.
FEMS Microbiology Letters
2014
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Gravelat FN, Beauvais A, Liu H, Lee MJ, Snarr BD, Chen D, Xu W, Kravtsov I, Hoareau CM, Vanier G, Urb M, Campoli P, Al Abdallah Q, Lehoux M, Chabot JC, Ouimet MC, Baptista SD, Fritz JH, Nierman WC, Latg�© JP, Mitchell AP, Filler SG, Fontaine T, Sheppard DC.
Aspergillus galactosaminogalactan mediates adherence to host constituents and conceals hyphal �²-glucan from the immune system.
PLoS Pathogens
2013
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Skamnaki VT, Peumans WJ, Kantsadi AL, Cubeta MA, Plas K, Pakala S, Zographos SE, Smagghe G, Nierman WC, Van Damme EJ, Leonidas DD.
Structural analysis of the Rhizoctonia solani agglutinin reveals a domain-swapping dimeric assembly.
FEBS Journal
2013
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Varga JJ, Losada L, Zelazny AM, Kim M, McCorrison J, Brinkac L, Sampaio EP, Greenberg DE, Singh I, Heiner C, Ashby M, Nierman WC, Holland SM, Goldberg JB.
Draft genome sequences of Burkholderia cenocepacia ET12 lineage strains K56-2 and BC7.
Genome Announcements
2013
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Vipond J, Kane J, Hatch G, McCorrison J, Nierman WC, Losada L.
Sequence Determination of Burkholderia pseudomallei Strain NCTC 13392 Colony Morphology Variants.
Genome Announcements
2013
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Thomas E, Pakala S, Fedorova ND, Nierman WC, Cubeta MA.
Triallelic SNP-mediated genotyping of regenerated protoplasts of the heterokaryotic fungus Rhizoctonia solani.
Journal of Biotechnology
2012
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Zhang D, Lax AR, Henrissat B, Coutinho P, Katiya N, Nierman WC, Fedorova N.
Carbohydrate-active enzymes revealed in Coptotermes formosanus (Isoptera: Rhinotermitidae) transcriptome.
Insect Molecular Biology
2012
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Chaturvedi V, Nierman WC.
Cryptococcus gattii comparative genomics and transcriptomics: A NIH/NIAID white paper.
Mycopathologia
2011
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Feng X, Krishnan K, Richie DL, Aimanianda V, Hartl L, Grahl N, Powers-Fletcher MV, Zhang M, Fuller KK, Nierman WC, Lu LJ, Latgé JP, Woollett L, Newman SL, Cramer RA, Rhodes JC, Askew DS.
HacA-independent functions of the ER stress sensor IreA synergize with the canonical UPR to influence virulence traits in Aspergillus fumigatus.
PLoS Pathogens
2011
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Guo B, Fedorova ND, Chen X, Wan CH, Wang W, Nierman WC, Bhatnagar D, Yu J.
Gene expression profiling and identification of resistance genes to Aspergillus flavus infection in peanut through EST and microarray strategies.
Toxins (Basel)
2011
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Huntley S, Hamann N, Wegener-Feldbrügge S, Treuner-Lange A, Kube M, Reinhardt R, Klages S, Müller R, Ronning CM, Nierman WC, Søgaard-Andersen L.
Comparative genomic analysis of fruiting body formation in Myxococcales.
Molecular Biology and Evolution
2011
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Kang Y, Norris MH, Zarzycki-Siek J, Nierman WC, Donachie SP, Hoang TT.
Transcript amplification from single bacterium for transcriptome analysis.
Genome Research
2011
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Losada L, Varga JJ, Hostetler J, Radune D, Kim M, Durkin S, Schneewind O, Nierman WC.
Genome sequencing and analysis of Yersina pestis KIM D27, an avirulent strain exempt from select agent regulation.
PLoS One
2011
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Morton CO, Varga JJ, Hornbach A, Mezger M, Sennefelder H, Kneitz S, Kurzai O, Krappmann S, Einsele H, Nierman WC, Rogers TR, Loeffler J.
The temporal dynamics of differential gene expression in Aspergillus fumigatus interacting with human immature dendritic cells in vitro.
PLoS One
2011
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Sugui JA, Losada L, Wang W, Varga J, Ngamskulrungroj P, Abu-Asab M, Chang YC, O'Gorman CM, Wickes BL, Nierman WC, Dyer PS, Kwon-Chung KJ.
Identification and characterization of an Aspergillus fumigatus “supermater” pair.
mBio
2011
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Yu J, Fedorova ND, Montalbano BG, Bhatnagar D, Cleveland TE, Bennett JW, Nierman WC.
Tight control of mycotoxin biosynthesis gene expression in Aspergillus flavus by temperature as revealed by RNA-Seq.
FEMS Microbiology Letters
2011
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Ben-Ami R, Varga V, Lewis RE, May GS, Nierman WC, Kontoyiannis DP.
Characterization of a 5-azacytidine-induced developmental Aspergillus fumigatus variant.
Virulence
2010
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Liu H, Gravelat FN, Chiang LY, Chen D, Vanier G, Ejzykowicz DE, Ibrahim AS, Nierman WC, Sheppard DC, Filler SG.
Aspergillus fumigatus AcuM regulates both iron acquisition and gluconeogenesis.
Molecular Microbiology
2010
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Losada L, Ronning CM, DeShazer D, Woods D, Fedorova N, Kim HS, Shabalina SA, Pearson TR, Brinkac L, Tan P, Nandi T, Crabtree J, Badger J, Beckstrom-Sternberg S, Saqib M, Schutzer SE, Keim P, Nierman WC.
Continuing evolution of Burkholderia mallei through genome reduction and large-scale rearrangements.
Genome Biology and Evolution
2010
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Medema MH, Trefzer A, Kovalchuk A, van den Berg M, Müller U, Heijne W, Wu L, Alam MT, Ronning CM, Nierman WC, Bovenberg RA, Breitling R, Takano E.
The sequence of a 1.8-mb bacterial linear plasmid reveals a rich evolutionary reservoir of secondary metabolic pathways.
Genome Biology and Evolution
2010
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Nandi T, Ong C, Singh AP, Boddey J, Atkins T, Sarkar-Tyson M, Essex-Lopresti AE, Chua HH, Pearson T, Kreisberg JF, Nilsson C, Ariyaratne P, Ronning C, Losada L, Ruan Y, Sung WK, Woods D, Titball RW, Beacham I, Peak I, Keim P, Nierman WC, Tan P.
A genomic survey of positive selection in Burkholderia pseudomallei provides insights into the evolution of accidental virulence.
PLoS Pathogens
2010
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Ronning CM, Losada L, Brinkac L, Inman J, Ulrich RL, Schell M, Nierman WC, Deshazer D.
Genetic and phenotypic diversity in Burkholderia: contributions by prophage and phage-like elements.
BMC Microbiology
2010
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Song H, Hwang J, Yi H, Ulrich RL, Yu Y, Nierman WC, Kim HS.
The early stage of bacterial genome-reductive evolution in the host.
PLoS Pathogens
2010
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