Kathryn V. Holmes, Ph.D.

Selected Publications

• Dominguez SR, Shrisastava S, Berglund A, Qian Z, Goes LG, Halpin RA, Fedorova NB, Ransier A, Weston PA, Durigon EL, Jerez JA, Robinson CC, Town CD, Holmes KV.

  Isolation, propagation, genome analysis, and epidemiology of HKU1 Betacoronaviruses from Colorado and Brazil.

  Journal of General Virology 2014 more details...
  
• Holmes KV, Dominguez SR.

  The new age of virus discovery: genomic analysis of a novel human betacoronavirus isolated from a fatal case of pneumonia.

  MBio 2013 more details...
  
• Qian Z, Dominguez SR, Holmes KV.

  Role of the spike glycoprotein of human Middle East respiratory syndrome coronavirus (MERS-CoV) in virus entry and syncytia formation.

  PLoS One 2013 more details...
  
• Qian Z, Travanty EA, Oko L, Edeen K, Berglund A, Wang J, Ito Y, Holmes KV, Mason R.

  Innate immune response of human alveolar type II cells infected with SARS-coronavirus.

  American Journal of Respiratory Cell and Molecular Biology 2013 more details...
  
• Chen L, Chen Z, Baker K, Halvorsen EM, da Cunha AP, Flak MB, Gerber G, Huang YH, Hosomi S, Arthur JC, Dery KJ, Nagaishi T, Beauchemin N, Holmes KV, Ho JW, Shively JE, Jobin C, Onderdonk AB, Bry L, Weiner HL, Higgins DE, Blumberg RS.

  The short isoform of the CEACAM1 receptor in intestinal T cells regulates mucosal immunity and homeostasis via Tfh cell induction.

  Immunity 2012 more details...
  
• Dominguez SR, Sims GE, Wentworth DE, Halpin RA, Robinson CC, Town CD, Holmes KV.

  Genomic analysis of 16 Colorado human NL63 coronaviruses identifies a new genotype, high sequence diversity in the N-terminal domain of the spike gene and evidence of recombination.

  Journal of General Virology 2012 more details...
  
• Funk CJ, Wang J, Ito Y, Travanty EA, Voelker DR, Holmes KV, Mason RJ.

  Infection of human alveolar macrophages by human coronavirus strain 229E.

  Journal of General Virology 2012 more details...
  
• Peng G, Xu L, Lin YL, Chen L, Pasquarella JR, Holmes KV, Li F.

  Crystal structure of bovine coronavirus spike protein lectin domain.

  Journal of Biological Chemistry 2012 more details...
  
• Lu SX, Kappel LW, Charbonneau-Allard AM, Atallah R, Holland AM, Turbide C, Hubbard VM, Rotolo JA, Smith M, Suh D, King C, Rao UK, Yim N, Bautista JL, Jenq RR, Penack O, Na IK, Liu C, Murphy G, Alpdogan O, Blumberg RS, Macian F, Holmes KV, Beauchemin N, van den Brink MR.

  Ceacam1 separates graft-versus-host-disease from graft-versus-tumor activity after experimental allogeneic bone marrow transplantation.

  PLoS One 2011 more details...
  
• Osborne C, Cryan PM, O'Shea TJ, Oko LM, Ndaluka C, Calisher CH, Berglund AD, Klavetter ML, Bowen RA, Holmes KV, Dominguez SR.

  Alphacoronaviruses in New World bats: prevalence, persistence, phylogeny, and potential for interaction with humans.

  PLoS One 2011 more details...
  
• Peng G, Sun D, Rajashankar KR, Qian Z, Holmes KV, Li F.

  Crystal structure of mouse coronavirus receptor-binding domain complexed with its murine receptor.

  Proceedings of the National Academy of Sciences USA 2011 more details...
  
• Hirai A, Ohtsuka N, Ikeda T, Taniguchi R, Blau D, Nakagaki K, Miura HS, Ami Y, Yamada YK, Itohara S, Holmes KV, Taguchi F.

  Role of mouse hepatitis virus (MHV) receptor murine CEACAM1 in the resistance of mice to MHV infection: studies of mice with chimeric mCEACAM1a and mCEACAM1b.

  Journal of Virology 2010 more details...
  
• Dominguez SR, Robinson CC, Holmes KV.

  Detection of four human coronaviruses in respiratory infections in children: a one-year study in Colorado.

  Journal of Medical Virology 2009 more details...
  
• Funk CJ, Manzer R, Miura TA, Groshong SD, Ito Y, Travanty EA, Leete J, Holmes KV, Mason RJ.

  Rat respiratory coronavirus infection: replication in airway and alveolar epithelial cells and the innate immune response.

  Journal of General Virology 2009 more details...
  
• Miura TA, Holmes KV.

  Host-pathogen interactions during coronavirus infection of primary alveolar epithelial cells.

  Journal of Leukocyte Biology 2009 more details...
  
• Yan Z, Holmes KV, Hodges RS.

  Expression and characterization of recombinant S2 subunit of SARS-coronavirus S fusion protein.

  Advances in Experimental Medicine and Biology 2009 more details...