Mukesh Kumar, Ph.D.
Associate Director, Biocontainment Core Assistant Professor Department of Tropical Medicine, Medical Microbiology and Pharmacology John A. Burns School of Medicine
Phone: (808) 692-1671
Office:
Email: mukesh [at] hawaii.edu
Bio
Education
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2007 |
B.V.Sc. & A.H. |
(Veterinary Science) College of Verterinary Science and Animal Husbandry, Jabalpur, India |
2010 |
M.S. |
(Biomedical Sciences) University of Hawaii at Manoa, Honolulu, HI |
2013 |
Ph.D. |
(Biomedical Sciences) University of Hawaii at Manoa, Honolulu, HI |
Research Keywords: Flaviviruses, pathogenesis, animal models
Selected Publications
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Krause K, Azouz F, Nakano E, Nerurkar VR, Kumar M.
Deletion of pregnancy zone protein and murinoglobulin-1 restricts the pathogenesis of West Nile virus infection in mice.
Frontiers in Microbiology
2019
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Kim J-A, Seong R-K, Kumar M, Shin OS.
Favipiravir and ribavirin inhibit replication of Asian and African strains of Zika virus in different cell models.
Viruses
2018
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To A, Medina LO, Mfuh KO, Lieberman MM, Wong TAS, Namekar M, Nakano E, Lai CY, Kumar M, Nerurkar VR, Lehrer AT.
Recombinant Zika virus subunits are immunogenic and efficacious in mice.
mSphere
2018
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Krause KK, Azouz F, Shin OS, Kumar M.
Understanding the pathogenesis of Zika virus infection using animal models.
Immune Network
2017
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Kumar M, Krause KK, Azouz F, Nakano E, Nerurkar VR.
A guinea pig model of Zika virus infection.
Virology Journal
2017
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Seong RK, Seo SW, Kim JA, Fletcher SJ, Morgan NV, Kumar M, Choi YK, Shin OS.
Schlafen 14 (SLFN14) is a novel antiviral factor involved in the control of viral replication.
Immunobiology
2017
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Culjat M, Darling SE, Nerurkar VR, Ching N, Kumar M, Min SK, Wong R, Grant L, Melish ME.
Clinical and imaging findings in an infant with Zika embryopathy.
Clinical Infectious Diseases
2016
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Gu SH, Kumar M, Sikorska B, Hejduk J, Markowski J, Markowski M, Liberski PP, Yanagihara R.
Isolation and partial characterization of a highly divergent lineage of hantavirus from the European mole (Talpa europaea).
Scientific Reports
2016
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Kumar M, Belcaid M, Nerurkar VR.
Identification of host genes leading to West Nile virus encephalitis in mice brain using RNA-seq analysis.
Scientific Reports
2016
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Kumar M, Ching L, Astern J, Lim E, Stokes AJ, Melish M, Nerurkar VR.
Antibodies to Zika virus in mothers from Hawaii who delivered babies with and without microcephaly between 2009-2012.
PLoS Neglected Tropical Diseases
2016
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Kumar M, Nerurkar VR.
In vitro and in vivo blood-brain barrier models to study West Nile virus pathogenesis.
Methods in Molecular Biology
2016
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Kim JA, Park SK, Kumar M, Lee CH, Shin OS.
Insights into the role of immunosenescence during varicella zoster virus infection (shingles) in the aging cell model.
Oncotarget
2015
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Kumar M, Roe K, O'Connell M, Nerurkar VR
Induction of virus-specific effector immune cell response limits virus replication and severe disease in mice infected with non-lethal West Nile virus Eg101 strain.
Journal of Neuroinflammation
2015
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Park SJ, Kumar M, Kwon HI, Seong RK, Han K, Song JM, Kim CJ, Choi YK, Shin OS.
Dynamic changes in host gene expression associated with H5N8 avian influenza virus infection in mice.
Scientific Reports
2015
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Kumar M, Nerurkar VR.
Integrated analysis of microRNAs and their disease related targets in the brain of mice infected with West Nile virus.
Virology
2014
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Kumar M, O'Connell M, Namekar M, Nerurkar VR.
Infection with non-lethal West Nile virus Eg101 strain induces immunity that protects mice against the lethal West Nile virus NY99 strain.
Viruses
2014
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Kumar M, Roe K, Nerurkar PV, Orillo B, Thompson KS, Verma S, Nerurkar VR.
Reduced immune cell infiltration and increased pro-inflammatory mediators in the brain of Type 2 diabetic mouse model infected with West Nile virus.
Journal of Neuroinflammation
2014
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Shin OS, Song GS, Kumar M, Yanagihara R, Lee HW, Song JW.
Hantaviruses induce antiviral and pro-inflammatory innate immune responses in astrocytic cells and the brain.
Viral Immunology
2014
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Kumar M, Roe K, Orillo B, Muruve DA, Nerurkar VR, Gale M, Verma S.
Inflammasome adaptor protein apoptosis-associated speck-like protein containing CARD (ASC) is critical for the immune response and survival in West Nile virus encephalitis.
Journal of Virology
2013
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Shin OS, Kumar M, Yanagihara R, Song JW.
Hantaviruses induce cell type- and viral species-specific host microRNA expression signatures.
Virology
2013
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Kumar M, Roe K, Nerurkar PV, Namekar M, Orillo B, Verma S, Nerurkar VR.
Impaired virus clearance, compromised immune response and increased mortality in Type 2 diabetic mice infected with West Nile virus.
PLoS One
2012
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Namekar M, Kumar M, O'Connell M, Nerurkar VR.
Effect of serum heat-inactivation and dilution on detection of anti-WNV antibodies in mice by West Nile virus E-protein microsphere immunoassay.
PLoS One
2012
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Roe K, Kumar M, Lum S, Orillo B, Nerurkar VR, Verma S.
West Nile virus-induced disruption of the blood-brain barrier in mice is characterized by the degradation of the junctional complex proteins and increase in multiple matrix metalloproteinases.
Journal of General Virology
2012
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Verma S, Hoffmann FW, Kumar M, Huang Z, Roe K, Nguyen-Wu E, Hashimoto AS, Hoffmann PR.
Selenoprotein K knockout mice exhibit deficient calcium flux in immune cells and impaired immune responses.
Journal of Immunology
2011
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Verma S, Kumar M, Nerurkar VR.
Cyclooxygenase-2 inhibitor blocks the production of West Nile virus-induced neuroinflammatory markers in astrocytes.
Journal of General Virology
2011
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Kumar M, Verma S, Nerurkar VR.
Pro-inflammatory cytokines derived from West Nile virus (WNV)-infected SK-N-SH cells mediate neuroinflammatory markers and neuronal death.
Journal of Neuroinflammation
2010
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Verma S, Kumar M, Gurjav U, Lum S, Nerurkar VR.
Reversal of West Nile virus-induced blood-brain barrier disruption and tight junction proteins degradation by matrix metalloproteinases inhibitor.
Virology
2010
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Grants
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Grant No / Title: R21OD024896 / A Guinea Pig Model of Zika Virus Disease
Status / Agency: Awarded / NIH/OD
Start Date / End Date: 01 September 2017 / 31 August 2019
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Grant No / Title: R21NS099838 / Defining the Function of Schlafen4 in the Pathogenesis of Flavivirus Encephalitis
Status / Agency: Awarded / NIH/NINDS
Start Date / End Date: 01 September 2016 / 31 August 2018
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