Marked relationship between matrix metalloproteinase 7 and brain atrophy in HIV infection.

Ragin AB, Wu Y, Ochs R, Du H, Epstein LG, Conant K, McArthur JC.

Citation

Ragin AB, Wu Y, Ochs R, Du H, Epstein LG, Conant K, McArthur JC. (2011) Marked relationship between matrix metalloproteinase 7 and brain atrophy in HIV infection. Journal of Neurovirology 17(2):153-158.

Abstract

Circulating levels of matrix metalloproteinases (MMP-1 and 7) have been found to correlate with the severity of brain injury in HIV-infected subjects. This study used high-resolution neuroanatomic imaging and automated segmentation algorithms to clarify this relationship. Both metalloproteinases were significantly correlated with increased cerebrospinal fluid volume fraction. Comprehensive brain volumetric analysis revealed a more marked relationship with atrophy for MMP-7, which was significantly correlated with neural injury in multiple brain regions and nearly all ventricular measurements. MMP-7 was also correlated with measures of virologic and cognitive status.