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News & Research Highlights
18 August 2017: Northern/Pacific Global Health Research Fellows Training Consortium
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The University of Hawaii at Manoa, under the leadership of Vivek R. Nerurkar, Ph.D., professor and chair of the Department of Tropical Medicine, Medical Microbiology and Pharmacology, of the John A. Burns School of Medicine, has successfully competed for renewed five-year funding for the Northern/Pa…


10 August 2017: Understanding Zika Virus Infection: The Development of an Animal Model

Zika virus is an emerging mosquito-borne pathogen, which has caused great concern to the international community. Eighty percent of individuals infected with Zika virus present no symptoms, however infection has been linked to development of severe fetal abnormalities including stillbirth and microc…


27 July 2017: Awardees of the 2017 COBRE Small Grants Program
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Funding has been awarded to four highly meritorious proposals, submitted in response to the COBRE Small Grants Program funding opportunity announcement (FOA).

Mukesh Kumar, Ph.D.
In utero Pathogenesis of African and Asian Zika Virus Strains in Guinea Pig

Axel T. Lehrer, Ph.D.
Innate …


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Recent Publications
Journal of Virology, 2017, Zika virus infects human Sertoli cells and modulates the integrity of the in vitro blood-testis barrier model.
Siemann DN, Strange DP, Maharaj PN, Shi PY, Verma S.

Confirmed reports of ZIKV in human seminal fluid for months after the clearance of viremia suggest the ability of ZIKV to establish persistent infection in the seminiferous tubules, an immune privileged site in the testis protected by the blood-testis barrier, also called the Sertoli cell barrier (S…


PLoS One, 2017, Timing of the human prenatal antibody response to Plasmodium falciparum antigens.
Yunga ST, Kayatani AK, Fogako J, Leke RJI, Leke RGF, Taylor DW.

Plasmodium falciparum (Pf)-specific T- and B-cell responses may be present at birth; however, when during fetal development antibodies are produced is unknown. Accordingly, cord blood samples from 232 preterm (20 to 37 weeks of gestation) and 450 term (37 weeks or more) babies were screened for IgM …


Frontiers in Microbiology, 2017, Ebola virus glycoprotein induces an innate immune response in vivo via TLR4.
Lai C-Y, Strange DP, Wong TAS, Lehrer AT, Verma S.

Ebola virus (EBOV), a member of the Filoviridae family, causes the most severe form of viral hemorrhagic fever. Although no FDA licensed vaccine or treatment against Ebola virus disease (EVD) is currently available, Ebola virus glycoprotein (GP) is the major antigen used in all candidate Ebola vacci…


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Seminars & Events
10 October 2017, 10:15 AM
Christopher C. Broder, Ph.D.
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Hendra Virus and Nipah Virus Therapy and Vaccine


04 October 2017, 12:00 PM
Jennifer Honda, Ph.D.
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Environmental, Host, and Nontuberculous Mycobacterial Factors that Interact to Cause Lung Disease in Hawaii


26 September 2017, 10:15 AM
Abhay R Satoskar, M.B.B.S., M.D., Ph.D.
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Drugs for Neglected Tropical Diseases: Current Challenges and Future Opportunities


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Workshops
21 October 2016, 10:00 AM
Alexandra Gurary, Ph.D.

Attune Nxt Training


20 October 2016, 03:30 PM
Alexandra Gurary, Ph.D.

Luminex Acquisition Software Training


20 October 2016, 10:00 AM
Alexandra Gurary, Ph.D.

Attune Nxt Training


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Recent Grants
NIH/OD, R21OD024896 A Guinea Pig Model of Zika Virus Disease
09/01/2017 - 08/31/2019
NIH/FIC, 2D43TW009345-06 Northern/Pacific Universities Global Health Research Training Consortium
07/01/2017 - 06/30/2022
NIH/NIAID, R01AI132323 Preclinical Development of a Thermostable Trivalent Filovirus Vaccine
06/20/2017 - 05/31/2022
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