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News & Research Highlights
03 April 2016: COBRE Small Grants Program - New Requirement

The COBRE Small Grants Program Funding Opportunity Announcement (FOA) has been revised. A new requirement has been added, in response to a recommendation made recently by the COBRE External Advisory Committee. The new requirement states: Budgets for proposed projects must indicate costs for specific…


16 March 2016: 2016 AAI Early Career Faculty Travel Grant

Dr. Mukesh Kumar, who serves as the Associate Director of the COBRE Biocontainment Core, has been selected as a recipient of the 2016 AAI Early Career Faculty Travel Grant to present his research, entitled Expression and regulatory effects of Schlafen genes in flavivirus infection, at the annual mee…


01 January 2016: COBRE Small Grants Program

The purpose of the Centers of Biomedical Research Excellence (COBRE) Small Grants Program is to provide support via three funding mechanisms to University of Hawaii (UH) faculty engaged in research in microbiology, immunology, emerging infectious diseases and tropical medicine. However, research pro…


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Recent Publications
Clinical Infectious Diseases, 2016, Clinical and imaging findings in an infant with Zika embryopathy.
Culjat M, Darling SE, Nerurkar VR, Ching N, Kumar M, Min SK, Wong R, Grant L, Melish ME.

Recent Zika virus (ZIKV) outbreaks have been associated with an increased incidence of neonatal microcephaly. Subsequently, tropism for the brain was established in human fetal brain tissue. We present the first congenital ZIKV infection in the United States, confirmed by high ZIKV IgM antibody tite…


Methods in Molecular Biology, 2016, In vitro and in vivo blood-brain barrier models to study West Nile virus pathogenesis.
Kumar M, Nerurkar VR.

The blood-brain barrier (BBB), a specialized interface between the peripheral blood circulation and the central nervous system, specifically regulates molecular and cellular flux between the two. It plays a critical role in the maintenance of brain hemostasis. The BBB restricts the entry of pathogen…


Vector Borne and Zoonotic Diseases, 2016, Genetic diversity of Artybash virus in the Laxmann's shrew (Sorex caecutiens).
Arai S, Kang HJ, Gu SH, Ohdachi SD, Cook JA, Yashina LN, Tanaka-Taya K, Abramov SA, Morikawa S, Okabe N, Oishi K, Yanagihara R.

Although based on very limited M and L segment sequences, Artybash virus (ARTV) was proposed previously as a unique hantavirus harbored by the Laxmann’s shrew (Sorex caecutiens). To verify this conjecture, lung tissues from 68 Laxmann’s shrews, captured during 2006 to 2014 in eastern Siberia,…


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Seminars & Events
23 May 2016, 12:00 PM - 1:00 PM
Alan D. Barrett, Ph.D.
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Why Does the Yellow Fever Live-attenuated 17D Vaccine Work?


20 May 2016, 12:00 PM - 1:00 PM
Alexander Freiberg, Ph.D.
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Antiviral Activity of Favipiravir Against Henipaviruses


09 May 2016, 12:00 PM - 1:00 PM
Indi Trehan, M.D., M.P.H., D.T.M.&H.
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Improving the Understanding of Childhood Malnutrition in sub-Saharan Africa


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Workshops
01 March 2016, 10:00 AM
Robert Durruthy-Durruthy, Ph.D.

Molecular and Cellular Immunology Core and Fluidigm Corporation Seminar: Single Cell Genomics Cutting Edge Microfluidic Tools Defy the Law of Averages by Enabling Resolution at the Single Cell Level


22 June 2015, 9:00 AM - 5:00 PM (Monday and Tuesday)
TBD

Software Carpentry Workshop


03 February 2015, 9:30 AM
Bela Desai, Ph.D.

Principles of Flow Cytometry and Applications


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Recent Grants
NIH/NIAID, R01AI119185 Defining a Protective Ebola Vaccine in Non-human Primates
08/28/2015 - 07/31/2019
Hawaii Community Foundation, 15ADVC-75878 West Nile Virus NS2B-NS3 Heterodimer as a Potential Target for Antiviral Drug Development
07/15/2015 - 01/14/2017
Department of Defense, U.S. Army Medical Research Acquisitions Administration, W81XWH-15-R-0015 US Army Medical Research Institute of Infectious Diseases (USAMRIID) Requirement to Develop, Produce and Deploy MAGPIX-Based Immunoassays
07/13/2015 - 07/12/2016
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