Previously, in an exploratory study of soricine shrews in central Poland, we reported the discovery of a novel hantavirus, designated Boginia virus (BOGV), in the Eurasian water shrew, as well as the detection of Seewis virus (SWSV) in the Eurasian common shrew. The overlapping geographic ranges of …

The precursor membrane (prM) protein of dengue virus (DENV) is present on the surface of immature virions. The role of nine highly conserved residues in the alpha-helical domain (MH) of the prM protein in DENV replication was investigated by alanine-substitution mutagenesis. Five mutants affected th…

The increased risk of severe dengue during repeat DENV infections appear to be due, at least in part, to the ability of pre-existing cross-reactive antibodies to form virus-antibody complexes and infect Fc-gamma receptor-bearing cells, known as antibody-dependent enhancement (ADE). The antigens and …

The triggering receptor expressed on myeloid cells (TREM) family of protein receptors is rapidly emerging as a critical regulator of a diverse array of cellular functions, including amplification of inflammation. Although the ligand(s) for TREM have not yet been fully identified, circumstantial evid…

Nova hantavirus (NVAV) was first identified in a single European mole (Talpa europaea), captured in Hungary. Analysis of lung tissues from 94 moles captured in France revealed NVAV in 50%. Based on the genetic diversity of the cytochrome b mtDNA, moles collected in Poitiers and Bordeaux were more cl…

Previously, we reported the discovery of a genetically distinct hantavirus, designated Boginia virus (BOGV), in the Eurasian water shrew (Neomys fodiens), as well as the detection of Seewis virus (SWSV) in the Eurasian common shrew (Sorex araneus), in central Poland. In this expanded study of 133 sh…