A collaborative study between COBRE investigators and researchers at Korea University has been published as the cover story in the August 2014 issue of Viral Immunology. The cover art shows the immunohistochemical detection of host glial fibrillary acidic protein and viral N protein in the brains of…

The discovery of hantavirus RNA in archival tissues from the Geata mouse shrew (Myosorex geata) and Kilimanjaro mouse shrew (Myosorex zinki) captured in Tanzania has been selected for the cover of the July 2014 issue of the Journal of Virology. As in earlier reports of previously unrecognized shrew-…

To determine whether miRNAs play a role in West Nile virus (WNV) neuropathogenesis, we evaluated WNV-infected mice brains for the expression profile of miRNAs, their potential functions and their correlation with genes involved in inflammatory pathways. Our data demonstrate that WNV infection modula…

Marine plankton account for much of the photosynthesis and respiration on our planet, and they influence the cycling of carbon and the distribution of nutrients on a global scale. Despite the fundamental importance of viruses to plankton ecology and evolution, most of the viruses in the sea, and the…

Burkholderia pseudomallei isolates from the Western Hemisphere are difficult to differentiate from those from regions in which melioidosis is traditionally endemic. We used internal transcribed spacer typing to determine that B. pseudomallei isolates from the Western Hemisphere are consistently type…

Although hantaviruses are not generally considered neurotropic, neurological complications have been reported occasionally in patients with hemorrhagic fever renal syndrome (HFRS). In this study, we analyzed innate immune responses to hantavirus infection in vitro in human astrocytic cells (A172) an…