The University of Hawaii at Manoa, under the leadership of Vivek R. Nerurkar, Ph.D., professor and chair of the Department of Tropical Medicine, Medical Microbiology and Pharmacology, of the John A. Burns School of Medicine, has successfully competed for renewed five-year funding for the Northern/Pa…

Zika virus is an emerging mosquito-borne pathogen, which has caused great concern to the international community. Eighty percent of individuals infected with Zika virus present no symptoms, however infection has been linked to development of severe fetal abnormalities including stillbirth and microc…

Funding has been awarded to four highly meritorious proposals, submitted in response to the COBRE Small Grants Program funding opportunity announcement (FOA).

Mukesh Kumar, Ph.D.
In utero Pathogenesis of African and Asian Zika Virus Strains in Guinea Pig

Axel T. Lehrer, Ph.D.
Innate …

Ebola virus (EBOV), a member of the Filoviridae family, causes the most severe form of viral hemorrhagic fever. Although no FDA licensed vaccine or treatment against Ebola virus disease (EVD) is currently available, Ebola virus glycoprotein (GP) is the major antigen used in all candidate Ebola vacci…

Infections with filoviruses in humans are highly virulent, causing hemorrhagic fevers which result in up to 90% mortality. In addition to natural infections, the ability to use these viruses as bioterrorist weapons is of significant concern. Currently, there are no licensed vaccines or therapeutics …

Schlafen (SLFN) proteins have been suggested to play important functions in cell proliferation and immune cell development. In this study, we determined the antiviral activities of putative RNA-helicase domain-containing SLFN14. Murine SLFN14 expression was specifically induced by TLR3-mediated path…