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News & Research Highlights
21 June 2016: A Novel Mole-borne Hantavirus
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Following multiple failed attempts, a previously unrecognized hantavirus, designated Dahonggou Creek virus (DHCV), was detected in archival frozen tissues of a long-tailed mole (Scaptonyx fusicaudus), captured in Shimian County, Sichuan Province, People’s Republic of China, in August 1989. Analyses …


07 June 2016: Position Available: Research Support (Senior Research Associate)

Works closely with the Department Chair to ensure there is adequate staff support for the supervision and maintenance of the Departmental teaching and research facility at the John A. Burns School of Medicine (JABSOM).

Monitors and maintains laboratory records, ensuring compliance with safety…


30 May 2016: RNA-seq Analysis of West Nile Virus Differential Pathogenicity
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RNA-seq technology was used to analyze host transcriptomes in the brains of mice experimentally infected with West Nile virus (WNV) NY99 (virulent strain) and WNV Eg101 (non-virulent strain) to gain insights into the underlying mechanisms of differential pathogenicity. Genes that were up-regulated i…


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Recent Publications
Methods in Molecular Biology, 2016, Functional analysis of West Nile virus proteins in human cells.
Kaufusi PH, Tseng A, Nerurkar VR.

West Nile Virus (WNV) lineage 2 strains have been responsible for large outbreaks of neuroinvasive disease in the United States and Europe between 1999 and 2012. Different strains in this lineage have previously been shown to produce either severe or mild neuroinvasive disease in mice. Phylogenetic …


Elife, 2016, Comparative genomics explains the evolutionary success of reef-forming corals.
Bhattacharya D, Agrawal S, Aranda M, Baumgarten S, Belcaid M, Drake JL, Erwin D, Foret S, Gates RD, Gruber DF, Kamel B, Lesser MP, Levy O, Liew YJ, MacManes M, Mass T, Medina M, Mehr S, Meyer E, Price DC, Putnam HM, Qiu H, Shinzato C, Shoguchi E, Stokes AJ, Tambutt S, Tchernov D, Voolstra CR, Wagner N, Walker CW, Weber AP, Weis V, Zelzion E, Zoccola D, Falkowski PG.

Transcriptome and genome data from twenty stony coral species and a selection of reference bilaterians were studied to elucidate coral evolutionary history. We identified genes that encode the proteins responsible for the precipitation and aggregation of the aragonite skeleton on which the organisms…


Scientific Reports, 2016, Identification of host genes leading to West Nile virus encephalitis in mice brain using RNA-seq analysis.
Kumar M, Belcaid M, Nerurkar VR.

Differential host responses may be critical determinants of distinct pathologies of West Nile virus (WNV) NY99 (pathogenic) and WNV Eg101 (non-pathogenic) strains. We employed RNA-seq technology to analyze global differential gene expression in WNV-infected mice brain and to identify the host cellul…


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Seminars & Events
29 June 2016, 11:00 AM - 12:00 PM
Pramila Walpita, Ph.D.
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Mammalian Cell-derived Virus-like Particle (VLP) Vaccine Platform


20 June 2016, 12:00 PM - 1:00 PM
Jerome H. Kim, M.D.
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Discover, Develop, Deliver: Work on Vaccines for Global Health at the International Vaccine Institute, Seoul


23 May 2016, 12:00 PM - 1:00 PM
Alan D. Barrett, Ph.D.
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Why Does the Yellow Fever Live-attenuated 17D Vaccine Work?


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Workshops
29 June 2016, 12:00 PM
Lisa Bellemare, Ph.D.

Multicolor Flow Cytometer Seminar: Optimizing Performance and Experimental Design for Multicolor Panel


01 March 2016, 10:00 AM
Robert Durruthy-Durruthy, Ph.D.

Molecular and Cellular Immunology Core and Fluidigm Corporation Seminar: Single Cell Genomics Cutting Edge Microfluidic Tools Defy the Law of Averages by Enabling Resolution at the Single Cell Level


22 June 2015, 9:00 AM - 5:00 PM (Monday and Tuesday)
TBD

Software Carpentry Workshop


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Recent Grants
NIH/NIAID, R01AI119185 Defining a Protective Ebola Vaccine in Non-human Primates
08/28/2015 - 07/31/2019
Hawaii Community Foundation, 15ADVC-75878 West Nile Virus NS2B-NS3 Heterodimer as a Potential Target for Antiviral Drug Development
07/15/2015 - 01/14/2017
Department of Defense, U.S. Army Medical Research Acquisitions Administration, W81XWH-15-R-0015 US Army Medical Research Institute of Infectious Diseases (USAMRIID) Requirement to Develop, Produce and Deploy MAGPIX-Based Immunoassays
07/13/2015 - 07/12/2017
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