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News & Research Highlights
07 December 2018: Efficacy of A Recombinant Subunit Protein-Based Zika Virus Vaccine in Non-human Primates
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Dr. Axel T. Lehrer, a former COBRE Small Grants Program awardee, and his research team have successfully developed a recombinant subunit protein-based vaccine for Zika virus. Previously, he demonstrated that this vaccine was effective in protecting mice from Zika virus challenge. These studies have …


09 November 2018: Stopping the Sting
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The 20-year pursuit of developing effective treatment regimens for box jellyfish envenomation by Angel Yanagihara, a Fulbright Specialist and former COBRE Small Grants Program awardee, is featured in the November 9, 2018 issue of Science.
https://www.sciencemag.org/news/2018/11/jellyfish-almost-kil...


08 October 2018: Efficacy of A Recombinant Subunit Protein-Based Zika Virus Vaccine

Zika Virus (ZIKV), a virus with no severe clinical symptoms or sequelae previously associated with human infection, became a public health threat following an epidemic in French Polynesia in 2013-2014 that resulted in neurological complications associated with infection. Although no treatment curren…


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Recent Publications
BMC Genomics, 2018, Plasma small ncRNA pair panels as novel biomarkers for early-stage lung adenocarcinoma screening.
Dou Y, Zhu Y, Ai J, Chen H, Liu H, Borgia JA, Li X, Yang F, Jiang B, Wang J, Deng Y.

BACKGROUND:
Lung cancer is a major cause of cancer-related mortality worldwide, and around two-thirds of patients have metastasis at diagnosis. Thus, detecting lung cancer at an early stage could reduce mortality. Aberrant levels of circulating small non-coding RNAs (small ncRNAs) are potential dia…


BMC Systems Biology, 2018, The emerging role of microRNA-4487/6845-3p in Alzheimer's disease pathologies is induced by Abeta25-35 triggered in SH-SY5Y cell.
Hu L, Zhang R, Yuan Q, Gao Y, Yang MQ, Zhang C, Huang J, Sun Y, Yang W, Yang JY, Min ZL, Cheng J, Deng Y, Hu X.

BACKGROUND:
Accumulation of amyloid beta-peptide (Abeta) is implicated in the pathogenesis and development of Alzheimer’s disease (AD). Neuron-enriched miRNA was aberrantly regulated and may be associated with the pathogenesis of AD. However, regarding whether miRNA is involved in the accumulation …


BMC Systems Biology , 2018, Increased AURKA promotes cell proliferation and predicts poor prognosis in bladder cancer.
Guo M, Lu S, Huang H, Wang Y, Yang MQ, Yang Y, Fan Z, Jiang B, Deng Y.

BACKGROUND:
Bladder cancer (BC) is the most common cancer of the urinary bladder and upper tract, in which the clinical management is limited. AURKA (aurora kinase A) has been identified as an oncogene in cancer development; however, its potential role and underlying mechanisms in the progression o…


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Seminars & Events
20 March 2019, 9:00 AM - 11:30 AM
Diane E. Griffin, M.D., Ph.D. (1), David A. Relman, M.D. (2), Edward G. Ruby, Ph.D. (3), Eric Rasmussen, M.D. (4)

2019 COBRE MINI-SYMPOSIUM


28 February 2019, 10:00 AM
Jolene Bradford, MLS, SCYM (ASCP)

Approaches for Microbial and Small Particle Analysis using Flow Cytometry


27 February 2019, 3:00 PM
Jolene Bradford, MLS, SCYM (ASCP)

Extracellular Vesicle and Small Particle Analysis Using Flow Cytometry


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Workshops
15 February 2019, 9:00 AM - 12:00 PM
Drs. Youping Deng, Mark Menor & Vedbar Khadka

Genome Assembly, Evaluation and Visualization


17 October 2018, 11:00 AM
Bela Desai, Ph.D.

Improving Protein Detection: Accurate, High-Sensitivity and High-Throughput Analysis of Biomarkers


21 September 2018, 10:00 AM
Basile Siewe, Ph.D.

Leverage The Power of Flow Cytometry


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Recent Grants
NIH/FIC, 1D71TW010434-01A1 Sustainable Research Training and Capacity Building in Liberia for Emerging Viral Epidemics
09/08/2017 - 08/31/2019
NIH/OD, R21OD024896 A Guinea Pig Model of Zika Virus Disease
09/01/2017 - 08/31/2019
NIH/FIC, 2D43TW009345-06 Northern/Pacific Universities Global Health Research Training Consortium
07/01/2017 - 06/30/2022
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