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News & Research Highlights
29 July 2014: West Nile Virus Neuroinvasive Disease
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To identify the mechanisms by which West Nile virus (WNV) causes disruption of the blood-brain barrier (BBB) and leukocyte migration into the brain, the role of endothelial cell adhesion molecules (CAMs) was studied in an in vitro BBB model. Permeability of the BBB model increased following leukocyt…


02 July 2014: Cover Art - Viral Immunology
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A collaborative study between COBRE investigators and researchers at Korea University has been published as the cover story in the August 2014 issue of Viral Immunology. The cover art shows the immunohistochemical detection of host glial fibrillary acidic protein and viral N protein in the brains of…


04 June 2014: Cover Art - Journal of Virology
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The discovery of hantavirus RNA in archival tissues from the Geata mouse shrew (Myosorex geata) and Kilimanjaro mouse shrew (Myosorex zinki) captured in Tanzania has been selected for the cover of the July 2014 issue of the Journal of Virology. As in earlier reports of previously unrecognized shrew-…


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Recent Publications
PLoS One, 2014, West Nile virus-induced cell adhesion molecules on human brain microvascular endothelial cells regulate leukocyte adhesion and modulate permeability of the in vitro blood-brain barrier model.
Roe K, Orillo B, Verma S.

Characterizing the mechanisms by which West Nile virus (WNV) causes blood-brain barrier (BBB) disruption, leukocyte infiltration into the brain and neuroinflammation is important to understand the pathogenesis of WNV encephalitis. Here, we examined the role of endothelial cell adhesion molecules (CA…


PLoS One, 2014, Characterization of the ectodomain of the envelope protein of dengue virus type 4: expression, membrane association, secretion and particle formation in the absence of precursor membrane protein.
Hsieh SC, Tsai WY, Nerurkar VR, Wang WK.

Considering the enhancement of DENV infectivity by anti-prM antibodies, our findings provide new insights into the expression and secretion of E protein ectodomain in the absence of prM protein and contribute to future subunit vaccine design….


MBio, 2014, The characterization of RNA viruses in tropical seawater using targeted PCR and metagenomics.
Culley AI, Mueller JA, Belcaid M, Wood-Charlson EM, Poisson G, Steward GF.

Marine plankton account for much of the photosynthesis and respiration on our planet, and they influence the cycling of carbon and the distribution of nutrients on a global scale. Despite the fundamental importance of viruses to plankton ecology and evolution, most of the viruses in the sea, and the…


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Seminars & Events
05 June 2014, 11:00 AM - 12:00 PM
David M. Morens, M.D.
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A History of Contagion


02 May 2014, 10:30 AM - 11:30 AM
Theresa Russell

Single Cell Genomics Seminar: Cutting Edge Microfluidic Tools Defy the Law of Averages by Enabling Resolution at the Single Cell Level


23 April 2014, 12:00 PM - 1:00 PM
Richard Yanagihara, M.D.
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Hantavirus Hunting Beyond the Lamp Post


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Workshops
15 March 2013, 1:00 PM - 3:30 PM
Robert Bowers, Ph. D.

Using QIIME for Microbial Community Analysis


13 November 2012, 9:00 AM - 5:00 PM
Pawel Michalak, Ph.D.

RNA-seq


08 November 2012, 1:00 PM
Mirja Wine, Ph.D.

Considerations for Monitoring Immune Cells by Flow Cytometry, Signal Transduction Pathways, Intracellular Proteins, and Tetramers


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Recent Grants
NIH/NIAID, R01AI110769 Mature Virus-like Particles as a New Strategy for Dengue Virus Vaccines
04/01/2014 - 03/31/2019
NIH/NIAID, R21AI105286 Defining Immunity to Placental Malaria using a Multi-assay Predictive Model
03/01/2014 - 02/28/2016
NIH/NIMHD, T37MD008636 International Biomedical Research Training for Hawaiian & Pacific Island Students
12/01/2013 - 11/30/2018
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